{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:34:05Z","timestamp":1789767245177,"version":"4.0.1"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"17","license":[{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2022NSFSC1454"],"award-info":[{"award-number":["2022NSFSC1454"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Individuals with anxiety and depression symptoms are vulnerable to sleep disturbances. The current study aimed to explore the shared neuro-mechanisms underlying the effect of anxiety and depression symptoms on sleep quality. We recruited a cohort of 92 healthy adults who underwent functional magnetic resonance imaging scanning. We measured anxiety and depression symptoms using the Zung Self-rating Anxiety\/Depression Scales and sleep quality using the Pittsburgh Sleep Quality Index. Independent component analysis was used to explore the functional connectivity (FC) of brain networks. Whole-brain linear regression analysis showed that poor sleep quality was associated with increased FC in the left inferior parietal lobule (IPL) within the anterior default mode network. Next, we extracted the covariance of anxiety and depression symptoms using principal component analysis to represent participants\u2019 emotional features. Mediation analysis revealed that the intra-network FC of the left IPL mediated the association between the covariance of anxiety and depression symptoms and sleep quality. To conclude, the FC of the left IPL may be a potential neural substrate in the association between the covariance of anxiety and depression symptoms and poor sleep quality, and may serve as a potential intervention target for the treatment of sleep disturbance in the future.<\/jats:p>","DOI":"10.1093\/cercor\/bhad253","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T02:55:58Z","timestamp":1689044158000},"page":"9908-9916","source":"Crossref","is-referenced-by-count":14,"title":["Functional connectivity of the left inferior parietal lobule mediates the impact of anxiety and depression symptoms on sleep quality in healthy adults"],"prefix":"10.1093","volume":"33","author":[{"given":"Mingfeng","family":"Lai","sequence":"first","affiliation":[{"name":"Mental Health Center, West China Hospital of Sichuan University , Chengdu 610041, 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