{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:35:38Z","timestamp":1791236138271,"version":"4.1.0"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"18","license":[{"start":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T00:00:00Z","timestamp":1690588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Center for Neuroplasticity and Pain"},{"DOI":"10.13039\/501100001732","name":"Danish National Research Foundation","doi-asserted-by":"publisher","award":["DNRF121"],"award-info":[{"award-number":["DNRF121"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","award":["NNF21OC0072828"],"award-info":[{"award-number":["NNF21OC0072828"]}],"id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pain-related depression of corticomotor excitability has been explored using transcranial magnetic stimulation-elicited motor-evoked potentials. Transcranial magnetic stimulation-electroencephalography now enables non-motor area cortical excitability assessments, offering novel insights into cortical excitability changes during pain states. Here, pain-related cortical excitability changes were explored in the dorsolateral prefrontal cortex and primary motor cortex (M1). Cortical excitability was recorded in 24 healthy participants before (Baseline), during painful heat (Acute Pain), and non-noxious warm (Warm) stimulation at the right forearm in a randomized sequence, followed by a pain-free stimulation measurement. Local cortical excitability was assessed as the peak-to-peak amplitude of early transcranial magnetic stimulation evoked potential, whereas global-mean field power measured the global excitability. Relative to the Baseline, Acute Pain decreased the peak-to-peak amplitude in M1 and dorsolateral prefrontal cortex compared with Warm (both P\u2009&amp;lt;\u20090.05). A reduced global-mean field power was only found in M1 during Acute Pain compared with Warm (P\u2009=\u20090.003). Participants with the largest reduction in local cortical excitability under Acute Pain showed a negative correlation between dorsolateral prefrontal cortex and M1 local cortical excitability (P\u2009=\u20090.006). Acute experimental pain drove differential pain-related effects on local and global cortical excitability changes in motor and non-motor areas at a group level while also revealing different interindividual patterns of cortical excitability changes, which can be explored when designing personalized treatment plans.<\/jats:p>","DOI":"10.1093\/cercor\/bhad259","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T12:47:40Z","timestamp":1689770860000},"page":"9986-9996","source":"Crossref","is-referenced-by-count":27,"title":["Acute pain drives different effects on local and global cortical excitability in motor and prefrontal areas: insights into interregional and interpersonal differences in pain processing"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3211-3723","authenticated-orcid":false,"given":"Enrico","family":"De Martino","sequence":"first","affiliation":[{"name":"Center for Neuroplasticity and Pain (CNAP) , Department of Health Science and Technology, Faculty of Medicine, , Aalborg 9220 , Denmark"},{"name":"Aalborg University , Department of Health Science and Technology, Faculty of Medicine, , Aalborg 9220 , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adenauer","family":"Casali","sequence":"additional","affiliation":[{"name":"Institute of Science and Technology, Federal University of S\u00e3o Paulo , S\u00e3o Paulo 04021-001 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Casarotto","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences, University of Milan , Milan , Italy"},{"name":"IRCCS Fondazione Don Carlo Gnocchi , Milan 50143 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences, University of Milan , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Rosanova","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences, University of Milan , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Graven-Nielsen","sequence":"additional","affiliation":[{"name":"Center for Neuroplasticity and Pain (CNAP) , Department of Health Science and Technology, Faculty of Medicine, , Aalborg 9220 , Denmark"},{"name":"Aalborg University , Department of Health Science and Technology, Faculty of Medicine, , Aalborg 9220 , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ciampi de Andrade","sequence":"additional","affiliation":[{"name":"Center for Neuroplasticity and Pain (CNAP) , Department of Health Science and Technology, Faculty of Medicine, , Aalborg 9220 , Denmark"},{"name":"Aalborg University , Department of Health Science and Technology, 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