{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:47:16Z","timestamp":1790293636699,"version":"4.1.0"},"reference-count":88,"publisher":"Oxford University Press (OUP)","issue":"19","license":[{"start":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T00:00:00Z","timestamp":1693267200000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Innovation","award":["2022ZD0205000"],"award-info":[{"award-number":["2022ZD0205000"]}]},{"name":"Yunnan Fundamental Research Projects","award":["202301AS070060"],"award-info":[{"award-number":["202301AS070060"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Impairments in spatial navigation in humans can be preclinical signs of Alzheimer's disease. Therefore, cognitive tests that monitor deficits in spatial memory play a crucial role in evaluating animal models with early stage Alzheimer's disease. While Chinese tree shrews (Tupaia belangeri) possess many features suitable for Alzheimer's disease modeling, behavioral tests for assessing spatial cognition in this species are lacking. Here, we established reward-based paradigms using the radial-arm maze and cheeseboard maze for tree shrews, and tested spatial memory in a group of 12 adult males in both tasks, along with a control water maze test, before and after bilateral lesions to the hippocampus, the brain region essential for spatial navigation. Tree shrews memorized target positions during training, and task performance improved gradually until reaching a plateau in all 3 mazes. However, spatial learning was compromised post-lesion in the 2 newly developed tasks, whereas memory retrieval was impaired in the water maze task. These results indicate that the cheeseboard task effectively detects impairments in spatial memory and holds potential for monitoring progressive cognitive decline in aged or genetically modified tree shrews that develop Alzheimer's disease-like symptoms. This study may facilitate the utilization of tree shrew models in Alzheimer's disease research.<\/jats:p>","DOI":"10.1093\/cercor\/bhad283","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T15:14:18Z","timestamp":1693322058000},"page":"10303-10321","source":"Crossref","is-referenced-by-count":4,"title":["A comparison of behavioral paradigms assessing spatial memory in tree shrews"],"prefix":"10.1093","volume":"33","author":[{"given":"Cheng-Ji","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province , Kunming Institute of Zoology, , Kunming, Yunnan 650201 , China"},{"name":"Chinese Academy of Sciences , Kunming Institute of Zoology, , Kunming, Yunnan 650201 , China"},{"name":"National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility) , Kunming Institute of Zoology, , Kunming, Yunnan 650107 , China"},{"name":"Chinese Academy of Sciences , Kunming Institute of Zoology, , Kunming, Yunnan 650107 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Qing","family":"Hui","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province , Kunming Institute of Zoology, , Kunming, Yunnan 650201 , China"},{"name":"Chinese Academy of Sciences , Kunming Institute of Zoology, , Kunming, Yunnan 650201 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province , Kunming Institute of Zoology, , Kunming, Yunnan 650201 , China"},{"name":"Chinese Academy of Sciences , Kunming Institute of Zoology, , Kunming, Yunnan 650201 , China"},{"name":"National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility) , Kunming Institute of Zoology, , Kunming, Yunnan 650107 , China"},{"name":"Chinese Academy of Sciences , Kunming Institute of Zoology, , Kunming, Yunnan 650107 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Yang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province , Kunming Institute of Zoology, , Kunming, Yunnan 650201 , China"},{"name":"Chinese Academy of Sciences , Kunming Institute of Zoology, , Kunming, Yunnan 650201 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Cai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province , Kunming Institute of Zoology, , Kunming, Yunnan 650201 , China"},{"name":"Chinese Academy of Sciences , Kunming Institute of Zoology, , Kunming, Yunnan 650201 , China"},{"name":"National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility) , Kunming Institute of Zoology, , Kunming, Yunnan 650107 , China"},{"name":"Chinese Academy of Sciences , Kunming Institute of Zoology, , Kunming, Yunnan 650107 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2495-483X","authenticated-orcid":false,"given":"Li","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province , Kunming Institute of Zoology, , Kunming, Yunnan 650201 , China"},{"name":"Chinese Academy of Sciences , Kunming Institute of Zoology, , Kunming, Yunnan 650201 , China"},{"name":"National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility) , Kunming Institute of Zoology, , Kunming, Yunnan 650107 , China"},{"name":"Chinese Academy of Sciences , Kunming Institute of Zoology, , Kunming, Yunnan 650107 , China"},{"name":"Center for Excellence in Brain Science and Intelligence Technology, 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