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Genetic factors were reported to have important influences on cerebral blood flow. However, the profile of genetic contributions to cerebral blood flow in adolescents or young adults was underexplored. In this study, we recruited a sample of 65 pairs of same-sex adolescent or young adult twins undergoing resting arterial spin labeling imaging to conduct heritability analyses. Our findings indicate that genetic factors modestly affect cerebral blood flow in adolescents or young adults in the territories of left anterior cerebral artery and right posterior cerebral artery, with the primary contribution being to the frontal regions, cingulate gyrus, and striatum, suggesting a profile of genetic contributions to specific brain regions. Notably, the regions in the left hemisphere demonstrate the highest heritability in most regions examined. These results expand our knowledge of the genetic basis of cerebral blood flow in the developing brain and emphasize the importance of regional analysis in understanding the heritability of cerebral blood flow. Such insights may contribute to our understanding of the underlying genetic mechanism of brain functions and altered cerebral blood flow observed in youths with brain disorders.<\/jats:p>","DOI":"10.1093\/cercor\/bhad310","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T11:54:35Z","timestamp":1692878075000},"page":"10624-10633","source":"Crossref","is-referenced-by-count":1,"title":["Heritability of cerebral blood flow in adolescent and young adult twins: an arterial spin labeling perfusion imaging study"],"prefix":"10.1093","volume":"33","author":[{"given":"Yi","family":"Dang","sequence":"first","affiliation":[{"name":"Magnetic Resonance Imaging Research Center , Institute of Psychology, , Beijing 100101 , China"},{"name":"Chinese Academy of Sciences , Institute of Psychology, , Beijing 100101 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuwen","family":"He","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Behavioral Science, Institute of Psychology , Beijing 100101 , China"},{"name":"Center for Cognitive and Brain Sciences, University of Macau , Macao SAR 999078 , China"},{"name":"Department of Public Health and Medicinal Administration , Faculty of Health Sciences, , Macao SAR 999078 , China"},{"name":"University of Macau , Faculty of Health Sciences, , Macao SAR 999078 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dang","family":"Zheng","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Behavioral Science, Institute of Psychology , Beijing 100101 , China"},{"name":"China National Children's Center , Beijing 100035 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoming","family":"Wang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Behavioral Science, Institute of Psychology , Beijing 100101 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Mental Health, Institute of Psychology , Beijing 100101 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Magnetic Resonance Imaging Research Center , Institute of Psychology, , Beijing 100101 , China"},{"name":"Chinese Academy of Sciences , Institute of Psychology, , Beijing 100101 , China"},{"name":"CAS Key Laboratory of Behavioral Science, Institute of Psychology , Beijing 100101 , China"},{"name":"Department of Psychology, University of the Chinese Academy of Sciences , Beijing 100101 , China"},{"name":"The National Clinical Research Center for Mental Disorders , Beijing Anding Hospital, , Beijing 100029 , China"},{"name":"Capital Medical University , Beijing Anding Hospital, , Beijing 100029 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,8,23]]},"reference":[{"key":"2023100820582454400_ref1","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1038\/nn.4398","article-title":"Novel genetic loci underlying human intracranial volume identified through genome-wide association","volume":"19","author":"Adams","year":"2016","journal-title":"Nat Neurosci"},{"key":"2023100820582454400_ref2","doi-asserted-by":"crossref","first-page":"5903","DOI":"10.1073\/pnas.91.13.5903","article-title":"Importance of nitric oxide for local increases of blood flow in rat cerebellar cortex during electrical stimulation","volume":"91","author":"Akg\u00f6ren","year":"1994","journal-title":"Proc Natl Acad Sci"},{"key":"2023100820582454400_ref3","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/mrm.25197","article-title":"Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: a 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