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The study explored the relationship between regional amyloid-\u03b2 accumulation and multiple cognitions and study their application value in the Alzheimer\u2019s disease diagnosis. 135 participants completed 18F-florbetapir Positron Emission Tomography (PET), structural MRI, and a cognitive battery. Partial correlation was used to examine the relationship between global and regional amyloid-\u03b2 accumulation and cognitions. Then, a support vector machine was applied to determine whether cognition-related accumulation regions can adequately distinguish the cognitively normal controls (76 participants) and mild cognitive impairment (30 participants) groups or mild cognitive impairment and Alzheimer\u2019s disease (29 participants) groups. The result showed that amyloid-\u03b2 accumulation regions were mainly located in the frontoparietal cortex, calcarine fissure, and surrounding cortex and temporal pole regions. Episodic memory-related regions included the frontoparietal cortices; executive function-related regions included the frontoparietal, temporal, and occipital cortices; and processing speed-related regions included the frontal and occipital cortices. Support vector machine analysis showed that only episodic memory-related amyloid-\u03b2 accumulation regions had better classification performance during the progression of Alzheimer\u2019s disease. Assessing regional changes in amyloid, particularly in frontoparietal regions, can aid in the early detection of amyloid-related decline in cognitive function.<\/jats:p>","DOI":"10.1093\/cercor\/bhad369","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T06:16:36Z","timestamp":1697782596000},"page":"11329-11338","source":"Crossref","is-referenced-by-count":4,"title":["Multi-domain cognition dysfunction accompanies frontoparietal and temporal amyloid accumulation in the elderly"],"prefix":"10.1093","volume":"33","author":[{"given":"Dandan","family":"Wang","sequence":"first","affiliation":[{"name":"Beijing Normal University State Key Laboratory of Cognitive Neuroscience and Learning, , No. 19, Xinjiekouwai St, Haidian District, Beijing, 100875, P.R .","place":["China"]},{"name":"Beijing Normal University Beijing Aging Brain Rejuvenation Initiative (BABRI) Center, , No. 19, Xinjiekouwai St, Haidian District, Beijing, 100875, P.R .","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing Normal University State Key Laboratory of Cognitive Neuroscience and Learning, , No. 19, Xinjiekouwai St, Haidian District, Beijing, 100875, P.R .","place":["China"]},{"name":"Beijing Normal University Beijing Aging Brain Rejuvenation Initiative (BABRI) Center, , No. 19, Xinjiekouwai St, Haidian District, Beijing, 100875, P.R .","place":["China"]},{"name":"Beijing Normal University School of Artificial Intelligence, , No. 19, Xinjiekouwai St, Haidian District, Beijing, 100875, P.R .","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxi","family":"Dang","sequence":"additional","affiliation":[{"name":"Beijing Normal University State Key Laboratory of Cognitive Neuroscience and Learning, , No. 19, Xinjiekouwai St, Haidian District, Beijing, 100875, P.R .","place":["China"]},{"name":"Beijing Normal University Beijing Aging Brain Rejuvenation Initiative (BABRI) Center, , No. 19, Xinjiekouwai St, Haidian District, Beijing, 100875, P.R .","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Sang","sequence":"additional","affiliation":[{"name":"Beijing Normal University State Key Laboratory of Cognitive Neuroscience and Learning, , No. 19, Xinjiekouwai St, Haidian District, Beijing, 100875, P.R .","place":["China"]},{"name":"Beijing Normal University Beijing Aging Brain Rejuvenation Initiative (BABRI) Center, , No. 19, Xinjiekouwai St, Haidian District, Beijing, 100875, P.R .","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewei","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing Normal University Beijing Aging Brain Rejuvenation Initiative (BABRI) Center, , No. 19, Xinjiekouwai St, Haidian District, Beijing, 100875, P.R .","place":["China"]},{"name":"Banner Alzheimer\u2019s Institute , Phoenix, AZ 85006 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Normal University State Key Laboratory of Cognitive Neuroscience and Learning, , No. 19, Xinjiekouwai St, Haidian District, Beijing, 100875, P.R .","place":["China"]},{"name":"Beijing Normal University Beijing Aging Brain Rejuvenation Initiative (BABRI) Center, , No. 19, Xinjiekouwai St, Haidian District, Beijing, 100875, P.R .","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Normal University State Key Laboratory of Cognitive Neuroscience and Learning, , No. 19, Xinjiekouwai St, Haidian District, Beijing, 100875, P.R .","place":["China"]},{"name":"Beijing Normal University Beijing Aging Brain Rejuvenation Initiative (BABRI) Center, , No. 19, Xinjiekouwai St, Haidian District, Beijing, 100875, P.R .","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,19]]},"reference":[{"issue":"5\u20136","key":"2024101804242271600_ref1","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1159\/000492945","article-title":"The precuneus - 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