{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T03:20:35Z","timestamp":1767842435787,"version":"3.49.0"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:00:00Z","timestamp":1700179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871325"],"award-info":[{"award-number":["81871325"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100698"],"award-info":[{"award-number":["82100698"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Project of Science and Technology Commission of Shanghai Municipality","award":["20Y11911800"],"award-info":[{"award-number":["20Y11911800"]}]},{"name":"Project of Chongming Science and Technology Commission of Shanghai Municipality","award":["CKY2021-41"],"award-info":[{"award-number":["CKY2021-41"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Functional constipation, a highly prevalent functional gastrointestinal disorder, often accompanies by mental and psychological disorders. Previous neuroimaging studies have demonstrated brain functional and structural alterations in patients with functional constipation. However, little is known about whether and how regional homogeneity is altered in these patients. Moreover, the potential genetic mechanisms associated with these alterations remain largely unknown. The study included 73 patients with functional constipation and 68 healthy controls, and regional homogeneity comparison was conducted to identify the abnormal spontaneous brain activities in patients with functional constipation. Using Allen Human Brain Atlas, we further investigated gene expression profiles associated with regional homogeneity alterations in functional constipation patients with partial least squares regression analysis applied. Compared with healthy controls, functional constipation patients demonstrated significantly decreased regional homogeneity in both bilateral caudate nucleus, putamen, anterior insula, thalamus and right middle cingulate cortex, supplementary motor area, and increased regional homogeneity in the bilateral orbitofrontal cortex. Genes related to synaptic signaling, central nervous system development, fatty acid metabolism, and immunity were spatially correlated with abnormal regional homogeneity patterns. Our findings showed significant regional homogeneity alterations in functional constipation patients, and the changes may be caused by complex polygenetic and poly-pathway mechanisms, which provides a new perspective on functional constipation\u2019s pathophysiology.<\/jats:p>","DOI":"10.1093\/cercor\/bhad403","type":"journal-article","created":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T04:32:52Z","timestamp":1700454772000},"source":"Crossref","is-referenced-by-count":4,"title":["Regional homogeneity alterations in patients with functional constipation and their associations with gene expression profiles"],"prefix":"10.1093","volume":"34","author":[{"given":"Wangli","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Radiology , Shanghai Tenth People\u2019s Hospital, , Shanghai 200072 , China"},{"name":"Tongji University School of Medicine , Shanghai Tenth People\u2019s Hospital, , Shanghai 200072 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongliang","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Colorectal Disease , Intestinal Microenvironment Treatment Center, , Shanghai 200072 , China"},{"name":"Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine , Intestinal Microenvironment Treatment Center, , Shanghai 200072 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiwen","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Radiology , Shanghai Tenth People\u2019s Hospital, , Shanghai 200072 , China"},{"name":"Tongji University School of Medicine , Shanghai Tenth People\u2019s Hospital, , Shanghai 200072 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Radiology , Shanghai Tenth People\u2019s Hospital, , Shanghai 200072 , China"},{"name":"Tongji 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, China"},{"name":"Tongji University School of Medicine , Shanghai Tenth People\u2019s Hospital, , Shanghai 200072 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqing","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Nursing , Wuliqiao Street Community Health Service Center, Shanghai 200023 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Chongming Branch of Shanghai Tenth People\u2019s Hospital , Shanghai 202157 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangyu","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Radiology , Shanghai Tenth People\u2019s Hospital, , Shanghai 200072 , China"},{"name":"Tongji University School of Medicine , Shanghai Tenth People\u2019s Hospital, , Shanghai 200072 , 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