{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:08:07Z","timestamp":1780448887090,"version":"3.54.1"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62303143"],"award-info":[{"award-number":["62303143"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hainan University Scientific Research Startup Fund Project","award":["RZ2200006115"],"award-info":[{"award-number":["RZ2200006115"]}]},{"name":"Hainan University Young Teacher Scientific Research Cultivation Project Fund","award":["XJ2300003535"],"award-info":[{"award-number":["XJ2300003535"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Personality traits are commonly regarded as relatively stable, whereas life satisfaction can fluctuate with time and circumstances, shaped by external influences and personal encounters. The correlation between personality traits and life satisfaction is well-established, yet the underlying neural mechanisms of the myelin-based microstructural brain network connecting them remain unclear. Here, we constructed individual-level whole-brain myelin microstructural networks from the MRI data of 1,043 healthy adults and performed correlation analysis to detect significant personality trait-related and life satisfaction-related subnetworks. A mediation analysis was used to verify whether the shared structural basis of personality traits and life satisfaction significantly mediated their association. The results showed that agreeableness positively correlated with life satisfaction. We identified a shared structural basis of the personality trait of agreeableness and life satisfaction. The regions comprising this overlapping network include the superior parietal lobule, inferior parietal lobule, and temporoparietal junction. Moreover, the shared microstructural connections mediate the association between the personality trait of agreeableness and life satisfaction. This large-scale neuroimaging investigation substantiates a mediation framework for understanding the microstructural connections between personality and life satisfaction, offering potential targets for assessment and interventions to promote human well-being.<\/jats:p>","DOI":"10.1093\/cercor\/bhad410","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T21:17:25Z","timestamp":1699651045000},"source":"Crossref","is-referenced-by-count":4,"title":["Cortical microstructural brain network mediates the association between personality trait of agreeableness and life satisfaction"],"prefix":"10.1093","volume":"34","author":[{"given":"Huijun","family":"Wu","sequence":"first","affiliation":[{"name":"School of Media & Communication, Shanghai Jiao Tong University , Shanghai 200240 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijia","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Psychological and Cognitive Sciences & Beijing Key Laboratory of Behavior and Mental Health, Peking University , Beijing 100871 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuyao","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Psychology, Nanjing Normal University , Nanjing 200097 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Physics and Optoelectronic Engineering, Hainan University , Haikou 570228 , China"},{"name":"G. Oppenheimer Center for Neurobiology of Stress & Resilience, UCLA , Los Angeles, CA 90095 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,11,8]]},"reference":[{"key":"2024011714472005400_ref1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jik.2017.11.002","article-title":"Personality traits, individual innovativeness and satisfaction with life","volume":"4","author":"Ali","year":"2019","journal-title":"J Innov Knowl"},{"key":"2024011714472005400_ref2","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.neuron.2010.02.005","article-title":"Functional-anatomic fractionation of the brain's default network","volume":"65","author":"Andrews-Hanna","year":"2010","journal-title":"Neuron"},{"key":"2024011714472005400_ref3","first-page":"588","article-title":"Personality stability and change: a meta-analysis of longitudinal 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