{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:44:48Z","timestamp":1782963888767,"version":"3.54.5"},"reference-count":111,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["RO1NS111029"],"award-info":[{"award-number":["RO1NS111029"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Characterized by enlarged brain ventricles, hydrocephalus is a common neurological disorder classically attributed to a primary defect in cerebrospinal fluid (CSF) homeostasis. Microcephaly (\u201csmall head\u201d) and hydrocephalus are typically viewed as two mutually exclusive phenomenon, since hydrocephalus is thought of as a fluid \u201cplumbing\u201d disorder leading to CSF accumulation, ventricular dilatation, and resultant macrocephaly. However, some cases of hydrocephalus can be associated with microcephaly. Recent work in the genomics of congenital hydrocephalus (CH) and an improved understanding of the tropism of certain viruses such as Zika and cytomegalovirus are beginning to shed light into the paradox \u201cmicrocephalic hydrocephalus\u201d by defining prenatal neural stem cells (NSC) as the spatiotemporal \u201cscene of the crime.\u201d In some forms of CH and viral brain infections, impaired fetal NSC proliferation leads to decreased neurogenesis, cortical hypoplasia and impaired biomechanical interactions at the CSF\u2013brain interface that collectively engender ventriculomegaly despite an overall and often striking decrease in head circumference. The coexistence of microcephaly and hydrocephalus suggests that these two phenotypes may overlap more than previously appreciated. Continued study of both conditions may be unexpectedly fertile ground for providing new insights into human NSC biology and our understanding of neurodevelopmental disorders.<\/jats:p>","DOI":"10.1093\/cercor\/bhad432","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T17:42:41Z","timestamp":1700674961000},"source":"Crossref","is-referenced-by-count":5,"title":["The \u201cmicrocephalic hydrocephalus\u201d paradox as a paradigm of altered neural stem cell biology"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4513-7348","authenticated-orcid":false,"given":"Phan Q","family":"Duy","sequence":"first","affiliation":[{"name":"University of Virginia School of Medicine Department of Neurosurgery, , Charlottesville, VA 22908, United States"},{"name":"University of Virginia School of Medicine Department of Neuroscience, , Charlottesville, VA 22908, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5144-4635","authenticated-orcid":false,"given":"Neel H","family":"Mehta","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Department of Neurosurgery, , Boston, MA 02114, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5922-7547","authenticated-orcid":false,"given":"Kristopher T","family":"Kahle","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Department of Neurosurgery, , Boston, MA 02114, United States"},{"name":"Broad Institute of MIT and Harvard , Cambridge, MA 02142, United States"},{"name":"Massachusetts General Hospital Harvard Center for Hydrocephalus and Neurodevelopmental Disorders, , Boston, MA 02114, United 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