{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T11:55:10Z","timestamp":1771674910787,"version":"3.50.1"},"reference-count":104,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:00:00Z","timestamp":1702598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901390"],"award-info":[{"award-number":["81901390"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["SBK2015041859"],"award-info":[{"award-number":["SBK2015041859"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Research and Development Program of Social Development Foundation of Jiangsu Province","award":["BE2021616"],"award-info":[{"award-number":["BE2021616"]}]},{"name":"Key Research and Development Program of Social Development Foundation of Jiangsu Province","award":["BE2022678"],"award-info":[{"award-number":["BE2022678"]}]},{"name":"Key Projects of Nanjing Medical Science and Technology Development Fund","award":["ZKX200029"],"award-info":[{"award-number":["ZKX200029"]}]},{"name":"Nanjing Medical University Specialized Disease Cohort Project","award":["NMUC2020034"],"award-info":[{"award-number":["NMUC2020034"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The insula plays a significant role in the neural mechanisms of obsessive-compulsive disorder. Previous studies have identified functional and structural abnormalities in insula in obsessive-compulsive disorder patients. The predictive coding model in the context of interoception can explain the psychological and neuropathological manifestations observed in obsessive-compulsive disorder. The model is based on the degree of laminar differentiation of cerebral cortex. The interindividual differences in a local measure of brain structure often covary with interindividual differences in other brain regions. We investigated the anatomical network involving the insula in a drug-na\u00efve obsessive-compulsive disorder sample. We recruited 58 obsessive-compulsive disorder patients and 84 matched health controls. The cortical thickness covariance maps between groups were compared at each vertex. We also evaluated the modulation of Yale\u2013Brown Obsessive-Compulsive Scale scores and obsessive-compulsive disorder duration on thickness covariance. Our findings indicated that the thickness covariance seeded from granular and dysgranular insula are different compared with controls. The duration and severity of obsessive-compulsive disorder can modulate the thickness covariance of granular and dysgranular insula with posterior cingulate cortex and rostral anterior cingulate cortex. Our results revealed aberrant insular structural characteristics and cortical thickness covariance in obsessive-compulsive disorder patients, contributing to a better understanding of the involvement of insula in the pathological mechanisms underlying obsessive-compulsive disorder.<\/jats:p>","DOI":"10.1093\/cercor\/bhad469","type":"journal-article","created":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T12:19:36Z","timestamp":1702729176000},"source":"Crossref","is-referenced-by-count":1,"title":["Abnormalities of structural covariance of insular subregions in drug-na\u00efve OCD patients"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1791-7827","authenticated-orcid":false,"given":"Xuedi","family":"Zhang","sequence":"first","affiliation":[{"name":"Nanjing Brain Hospital Affiliated to Nanjing Medical University , Nanjing, Jiangsu 210029 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minyao","family":"Xie","sequence":"additional","affiliation":[{"name":"Nanjing Brain Hospital Affiliated to Nanjing Medical University , Nanjing, Jiangsu 210029 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wangyue","family":"Li","sequence":"additional","affiliation":[{"name":"Nanjing Brain Hospital Affiliated to Nanjing Medical University , Nanjing, Jiangsu 210029 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihan","family":"Xu","sequence":"additional","affiliation":[{"name":"Nanjing Brain Hospital Affiliated to Nanjing Medical University , Nanjing, Jiangsu 210029 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanjing Brain Hospital Affiliated to Nanjing Medical University , Nanjing, Jiangsu 210029 , 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