{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:30:07Z","timestamp":1791228607522,"version":"4.1.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62171101"],"award-info":[{"award-number":["62171101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82250410380"],"award-info":[{"award-number":["82250410380"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"China MOST2030 Brain Project","award":["2022ZD0208500"],"award-info":[{"award-number":["2022ZD0208500"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Alzheimer\u2019s disease (AD) is associated with functional disruption in gray matter (GM) and structural damage to white matter (WM), but the relationship to functional signal in WM is unknown. We performed the functional connectivity (FC) and graph theory analysis to investigate abnormalities of WM and GM functional networks and corpus callosum among different stages of AD from a publicly available dataset. Compared to the controls, AD group showed significantly decreased FC between the deep WM functional network (WM-FN) and the splenium of corpus callosum, between the sensorimotor\/occipital WM-FN and GM visual network, but increased FC between the deep WM-FN and the GM sensorimotor network. In the clinical groups, the global assortativity, modular interaction between occipital WM-FN and visual network, nodal betweenness centrality, degree centrality, and nodal clustering coefficient in WM- and GM-FNs were reduced. However, modular interaction between deep WM-FN and sensorimotor network, and participation coefficients of deep WM-FN and splenium of corpus callosum were increased. These findings revealed the abnormal integration of functional networks in different stages of AD from a novel WM-FNs perspective. The abnormalities of WM functional pathways connect downward to the corpus callosum and upward to the GM are correlated with AD.<\/jats:p>","DOI":"10.1093\/cercor\/bhad505","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T15:11:37Z","timestamp":1709219497000},"source":"Crossref","is-referenced-by-count":8,"title":["Altered white matter functional pathways in Alzheimer\u2019s disease"],"prefix":"10.1093","volume":"34","author":[{"given":"Yilu","family":"Li","sequence":"first","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute , MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, , NO. 2006, Xiyuan Ave, West Hi-Tech Zone, 611731, Chengdu , China"},{"name":"University of Electronic Science and Technology of China , MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, , NO. 2006, Xiyuan Ave, West Hi-Tech Zone, 611731, Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhong","family":"Peng","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute , MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, , NO. 2006, Xiyuan Ave, West Hi-Tech Zone, 611731, Chengdu , China"},{"name":"University of Electronic Science and Technology of China , MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, , NO. 2006, Xiyuan Ave, West Hi-Tech Zone, 611731, Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Yang","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute , MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, , NO. 2006, Xiyuan Ave, West Hi-Tech Zone, 611731, Chengdu , China"},{"name":"University of Electronic Science and Technology of China , MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, , NO. 2006, Xiyuan Ave, West Hi-Tech Zone, 611731, Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute , MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, , NO. 2006, Xiyuan Ave, West Hi-Tech Zone, 611731, Chengdu , China"},{"name":"University of Electronic Science and Technology of China , MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, , NO. 2006, Xiyuan Ave, West Hi-Tech Zone, 611731, Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Liu","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute , MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, , NO. 2006, Xiyuan Ave, West Hi-Tech Zone, 611731, Chengdu , China"},{"name":"University of Electronic Science and Technology of China , MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, , NO. 2006, Xiyuan Ave, West Hi-Tech Zone, 611731, Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Wang","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute , MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, , NO. 2006, Xiyuan Ave, West Hi-Tech Zone, 611731, Chengdu , China"},{"name":"University of Electronic Science and Technology of China , MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, , NO. 2006, Xiyuan Ave, West Hi-Tech Zone, 611731, Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharat B","family":"Biswal","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute , MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, , NO. 2006, Xiyuan Ave, West Hi-Tech Zone, 611731, Chengdu , China"},{"name":"University of Electronic Science and Technology of China , MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, , NO. 2006, Xiyuan Ave, West Hi-Tech Zone, 611731, Chengdu , China"},{"name":"Department of Biomedical Engineering , , 154 Summit Street, Newark 07102, NJ , United States"},{"name":"New Jersey Institute of Technology , , 154 Summit Street, Newark 07102, NJ , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,3]]},"reference":[{"issue":"4","key":"2024030412263281500_ref1","first-page":"1598","article-title":"Alzheimer\u2019s Disease Facts and Figures","volume":"19","year":"2023","journal-title":"Alzheimers Dement"},{"issue":"6","key":"2024030412263281500_ref2","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1002\/hbm.21287","article-title":"Damage to the cingulum contributes to alzheimer\u2019s disease pathophysiology by deafferentation mechanism","volume":"33","author":"Bozzali","year":"2012","journal-title":"Hum Brain Mapp"},{"issue":"4","key":"2024030412263281500_ref3","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/WCO.0000000000000345","article-title":"Quantitative MRI to understand Alzheimer\u2019s disease pathophysiology","volume":"29","author":"Bozzali","year":"2016","journal-title":"Curr Opin Neurol"},{"issue":"1","key":"2024030412263281500_ref4","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1146\/annurev-clinpsy-040510-143934","article-title":"Brain graphs: graphical models of the human brain connectome","volume":"7","author":"Bullmore","year":"2011","journal-title":"Annu Rev Clin Psychol"},{"issue":"40","key":"2024030412263281500_ref5","doi-asserted-by":"crossref","first-page":"10222","DOI":"10.1523\/JNEUROSCI.2250-06.2006","article-title":"Alterations in memory networks in mild cognitive impairment and Alzheimer\u2019s disease: an independent component analysis","volume":"26","author":"Celone","year":"2006","journal-title":"J Neurosci"},{"issue":"2","key":"2024030412263281500_ref6","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1093\/brain\/awx347","article-title":"Tau burden and the functional connectome in Alzheimer\u2019s disease and progressive supranuclear palsy","volume":"141","author":"Cope","year":"2018","journal-title":"Brain"},{"issue":"8","key":"2024030412263281500_ref7","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1002\/hbm.21333","article-title":"A whole brain fMRI atlas generated via spatially constrained spectral clustering","volume":"33","author":"Craddock","year":"2012","journal-title":"Hum Brain Mapp"},{"issue":"1","key":"2024030412263281500_ref8","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/ana.410290110","article-title":"Visual dysfunction in Alzheimer\u2019s disease: relation to normal aging","volume":"29","author":"Cronin-Golomb","year":"1991","journal-title":"Ann Neurol"},{"issue":"21","key":"2024030412263281500_ref9","doi-asserted-by":"crossref","first-page":"8191","DOI":"10.1523\/JNEUROSCI.0464-15.2015","article-title":"Cross-hemispheric collaboration and segregation associated with task difficulty as revealed by structural and functional connectivity","volume":"35","author":"Davis","year":"2015","journal-title":"J Neurosci"},{"issue":"3","key":"2024030412263281500_ref10","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1073\/pnas.1711567115","article-title":"Detection of synchronous brain activity in white matter tracts at rest and under functional loading","volume":"115","author":"Ding","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024030412263281500_ref11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fnhum.2015.00043","article-title":"High-dimensional ICA analysis detects within-network functional connectivity damage of default-mode and sensory-motor networks in Alzheimer\u2019s Disease","volume":"9","author":"Dipasquale","year":"2015","journal-title":"Front Hum Neurosci"},{"issue":"3","key":"2024030412263281500_ref12","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.neuroimage.2010.12.008","article-title":"DTI measures in crossing-fibre areas: increased diffusion anisotropy reveals early white matter alteration in MCI and mild Alzheimer\u2019s disease","volume":"55","author":"Douaud","year":"2011","journal-title":"NeuroImage"},{"issue":"8","key":"2024030412263281500_ref13","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.tins.2011.05.005","article-title":"Neuroimaging markers for the prediction and early diagnosis of Alzheimer\u2019s disease dementia","volume":"34","author":"Ewers","year":"2011","journal-title":"Trends Neurosci"},{"key":"2024030412263281500_ref14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/251308","article-title":"Functional topography of human corpus callosum: an fMRI mapping study","volume":"2013","author":"Fabri","year":"2013","journal-title":"Neural Plasticity"},{"key":"2024030412263281500_ref15","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.brainres.2010.11.039","article-title":"Topographical organization of human corpus callosum: an fMRI mapping study","volume":"1370","author":"Fabri","year":"2011","journal-title":"Brain Res"},{"issue":"1","key":"2024030412263281500_ref16","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/s41380-018-0067-8","article-title":"Changes in functional and structural brain connectome along the Alzheimer\u2019s disease continuum","volume":"25","author":"Filippi","year":"2020","journal-title":"Mol Psychiatry"},{"issue":"3","key":"2024030412263281500_ref17","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"Mini-mental state","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"issue":"3","key":"2024030412263281500_ref18","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1093\/brain\/awl377","article-title":"The topography of grey matter involvement in early and late onset Alzheimer\u2019s disease","volume":"130","author":"Frisoni","year":"2007","journal-title":"Brain"},{"issue":"10","key":"2024030412263281500_ref19","doi-asserted-by":"crossref","first-page":"e0240513","DOI":"10.1371\/journal.pone.0240513","article-title":"Functional connectivity of white matter as a biomarker of cognitive decline in Alzheimer\u2019s disease","volume":"15","author":"Gao","year":"2020","journal-title":"PLoS One"},{"key":"2024030412263281500_ref20","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.117278","article-title":"Detection of functional networks within white matter using independent component analysis","volume":"222","author":"Huang","year":"2020","journal-title":"NeuroImage"},{"issue":"4","key":"2024030412263281500_ref21","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1002\/hbm.24444","article-title":"Regional and network properties of white matter function in Parkinson\u2019s disease","volume":"40","author":"Ji","year":"2019","journal-title":"Hum Brain Mapp"},{"issue":"7","key":"2024030412263281500_ref22","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1017\/S0033291720003141","article-title":"Characteristics of disrupted topological organization in white matter functional connectome in schizophrenia","volume":"52","author":"Jiang","year":"2022","journal-title":"Psychol Med"},{"issue":"2","key":"2024030412263281500_ref23","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/brain\/awv338","article-title":"Cascading network failure across the Alzheimer\u2019s disease spectrum","volume":"139","author":"Jones","year":"2016","journal-title":"Brain"},{"issue":"10","key":"2024030412263281500_ref24","doi-asserted-by":"crossref","first-page":"5216","DOI":"10.3390\/ijms22105216","article-title":"Diffusion magnetic resonance imaging-based biomarkers for neurodegenerative diseases","volume":"22","author":"Kamagata","year":"2021","journal-title":"IJMS"},{"key":"2024030412263281500_ref25","article-title":"OASIS-3: longitudinal neuroimaging, clinical, and cognitive dataset for normal aging and Alzheimer Disease (preprint)","author":"LaMontagne","year":"2019","journal-title":"medRxiv"},{"issue":"1","key":"2024030412263281500_ref26","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1038\/s41467-019-09076-2","article-title":"Characterization of the hemodynamic response function in white matter tracts for event-related fMRI","volume":"10","author":"Li","year":"2019","journal-title":"Nat Commun"},{"issue":"1","key":"2024030412263281500_ref27","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/s41398-020-01053-4","article-title":"White-matter functional topology: a neuromarker for classification and prediction in unmedicated depression","volume":"10","author":"Li","year":"2020","journal-title":"Transl Psychiatry"},{"key":"2024030412263281500_ref28","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.117096","article-title":"Functional engagement of white matter in resting-state brain networks","volume":"220","author":"Li","year":"2020","journal-title":"NeuroImage"},{"issue":"1","key":"2024030412263281500_ref29","first-page":"29","article-title":"Voxel-based morphometry of brain MRI in normal aging and Alzheimer\u2019s disease","volume":"4","author":"Matsuda","year":"2013","journal-title":"Aging Dis"},{"issue":"20","key":"2024030412263281500_ref30","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevLett.89.208701","article-title":"Assortative mixing in networks","volume":"89","author":"Newman","year":"2002","journal-title":"Phys Rev Lett"},{"issue":"1","key":"2024030412263281500_ref31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3233\/JAD-141239","article-title":"Diffusion tensor imaging reveals visual pathway damage in patients with mild cognitive impairment and Alzheimer\u2019s Disease","volume":"45","author":"Nishioka","year":"2015","journal-title":"J Alzheimers Dis"},{"issue":"5","key":"2024030412263281500_ref32","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jalz.2012.05.2186","article-title":"Longitudinal, region-specific course of diffusion tensor imaging measures in mild cognitive impairment and Alzheimer\u2019s disease","volume":"9","author":"Nowrangi","year":"2013","journal-title":"Alzheimers Dement"},{"issue":"27","key":"2024030412263281500_ref33","doi-asserted-by":"crossref","first-page":"6394","DOI":"10.1523\/JNEUROSCI.3872-16.2017","article-title":"Evidence for functional networks within the human brain\u2019s white matter","volume":"37","author":"Peer","year":"2017","journal-title":"J Neurosci"},{"issue":"3","key":"2024030412263281500_ref34","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2796.2004.01388.x","article-title":"Mild cognitive impairment as a diagnostic entity","volume":"256","author":"Petersen","year":"2004","journal-title":"J Intern Med"},{"issue":"50","key":"2024030412263281500_ref35","doi-asserted-by":"crossref","first-page":"13278","DOI":"10.1073\/pnas.1707050114","article-title":"On the role of the corpus callosum in interhemispheric functional connectivity in humans","volume":"114","author":"Roland","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"2024030412263281500_ref36","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.neuroimage.2009.10.003","article-title":"Complex network measures of brain connectivity: uses and interpretations","volume":"52","author":"Rubinov","year":"2010","journal-title":"NeuroImage"},{"issue":"27","key":"2024030412263281500_ref37","doi-asserted-by":"crossref","first-page":"8463","DOI":"10.1073\/pnas.1420687112","article-title":"Ongoing dynamics in large-scale functional connectivity predict perception","volume":"112","author":"Sadaghiani","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024030412263281500_ref38","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3389\/fnhum.2012.00200","article-title":"Better ways to improve standards in brain-behavior correlation analysis","volume":"6","author":"Schwarzkopf","year":"2012","journal-title":"Front Hum Neurosci"},{"issue":"10","key":"2024030412263281500_ref39","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1093\/cercor\/bhl136","article-title":"Fiber connections between the cerebral cortex and the corpus callosum in Alzheimer\u2019s disease: a diffusion tensor imaging and voxel-based morphometry study","volume":"17","author":"Sydykova","year":"2007","journal-title":"Cereb Cortex"},{"issue":"3","key":"2024030412263281500_ref40","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jalz.2016.06.2358","article-title":"Tract-specific white matter hyperintensities disrupt neural network function in Alzheimer\u2019s disease","volume":"13","author":"Taylor","year":"2017","journal-title":"Alzheimers Dement"},{"issue":"5","key":"2024030412263281500_ref41","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1093\/cercor\/bhz311","article-title":"The organization of the human corpus callosum estimated by intrinsic functional connectivity with white-matter functional networks","volume":"30","author":"Wang","year":"2020","journal-title":"Cereb Cortex"},{"key":"2024030412263281500_ref42","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.117642","article-title":"Structural and functional connectivity mapping of the human corpus callosum organization with white-matter functional networks","volume":"227","author":"Wang","year":"2021","journal-title":"NeuroImage"},{"key":"2024030412263281500_ref43","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2023.119916","article-title":"White matter BOLD signals at 7 tesla reveal visual field maps in optic radiation and vertical occipital fasciculus","volume":"269","author":"Wang","year":"2023","journal-title":"NeuroImage"},{"issue":"4","key":"2024030412263281500_ref44","doi-asserted-by":"crossref","first-page":"995","DOI":"10.3233\/JAD-150196","article-title":"Following the spreading of brain structural changes in Alzheimer\u2019s Disease: a longitudinal, multimodal MRI study","volume":"47","author":"Weiler","year":"2015","journal-title":"JAD"},{"key":"2024030412263281500_ref45","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.neuroimage.2017.02.074","article-title":"Functional connectivity and activity of white matter in somatosensory pathways under tactile stimulations","volume":"152","author":"Wu","year":"2017","journal-title":"NeuroImage"},{"issue":"6","key":"2024030412263281500_ref46","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1093\/schbul\/sbx014","article-title":"Convergence and divergence of brain network dysfunction in deficit and non-deficit schizophrenia","volume":"43","author":"Yu","year":"2017","journal-title":"Schizophr Bull"},{"issue":"3","key":"2024030412263281500_ref47","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.neuroimage.2009.12.027","article-title":"Whole-brain anatomical networks: does the choice of nodes matter?","volume":"50","author":"Zalesky","year":"2010","journal-title":"NeuroImage"}],"container-title":["Cerebral Cortex"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cercor\/article-pdf\/34\/3\/bhad505\/56825380\/bhad505.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cercor\/article-pdf\/34\/3\/bhad505\/56825380\/bhad505.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T12:27:10Z","timestamp":1709555230000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cercor\/article\/doi\/10.1093\/cercor\/bhad505\/7618461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,1]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cercor\/bhad505","relation":{},"ISSN":["1047-3211","1460-2199"],"issn-type":[{"value":"1047-3211","type":"print"},{"value":"1460-2199","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,3]]},"published":{"date-parts":[[2024,3,1]]},"article-number":"bhad505"}}