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However, the neural mechanisms underlying this elicitation heterogeneity remain undiscovered. Here, we collected subjective reports following iES at 3062 intracranial sites in 28 patients (both sexes) and identified 113 auditory cortical sites with iES-elicited sound experiences. We then decomposed the sound-induced intracranial electroencephalogram (iEEG) signals recorded from all 113 sites into time-frequency features. We found that the iES-elicited perceived contents can be predicted by the early high-\u03b3 features extracted from sound-induced iEEG. In contrast, the perceived locations elicited by stimulating hallucination sites and illusion sites are determined by the late high-\u03b3 and long-lasting \u03b1 features, respectively. Our study unveils the crucial neural signatures of iES-elicited sound experiences in human and presents a new strategy to hearing restoration for individuals suffering from deafness.<\/jats:p>","DOI":"10.1093\/cercor\/bhad517","type":"journal-article","created":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T10:08:03Z","timestamp":1702721283000},"source":"Crossref","is-referenced-by-count":3,"title":["Neural response properties predict perceived contents and locations elicited by intracranial electrical stimulation of human auditory cortex"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2347-8798","authenticated-orcid":false,"given":"Qian","family":"Wang","sequence":"first","affiliation":[{"name":"School of Psychological and Cognitive Sciences and Beijing Key Laboratory of Behavior and Mental Health, Peking University , Beijing 100871 , China"},{"name":"IDG\/McGovern Institute for Brain Research, Peking University , Beijing 100871 , 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Brain Hospital, , Beijing 100093 , China"},{"name":"Capital Medical University , Beijing Key Laboratory of Epilepsy, Sanbo Brain Hospital, , Beijing 100093 , China"},{"name":"Epilepsy Center, Kunming Sanbo Brain Hospital , Kunming 650100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoming","family":"Luan","sequence":"additional","affiliation":[{"name":"Department of Functional Neurosurgery , Beijing Key Laboratory of Epilepsy, Sanbo Brain Hospital, , Beijing 100093 , China"},{"name":"Capital Medical University , Beijing Key Laboratory of Epilepsy, Sanbo Brain Hospital, , Beijing 100093 , China"},{"name":"Beijing Institute for Brain Disorders , Beijing 100069 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7718-2354","authenticated-orcid":false,"given":"Fang","family":"Fang","sequence":"additional","affiliation":[{"name":"School of Psychological and Cognitive Sciences and Beijing Key Laboratory of 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