{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:16:37Z","timestamp":1787008597217,"version":"build-2736575974"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Interfaculty Research Cooperation \u201cDecoding Sleep: From Neurons to Health & Mind\u201d of the University of Bern"},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["320030_188737"],"award-info":[{"award-number":["320030_188737"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["P300PA_174451"],"award-info":[{"award-number":["P300PA_174451"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["RONS21135"],"award-info":[{"award-number":["RONS21135"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIMH CONTE Center","award":["PO-MH109429"],"award-info":[{"award-number":["PO-MH109429"]}]},{"name":"Brain Initiative","award":["U19 NS1076"],"award-info":[{"award-number":["U19 NS1076"]}]},{"name":"Brain Initiative","award":["U01NS108916"],"award-info":[{"award-number":["U01NS108916"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Our brains extract structure from the environment and form predictions given past experience. Predictive circuits have been identified in wide-spread cortical regions. However, the contribution of medial temporal structures in predictions remains under-explored. The hippocampus underlies sequence detection and is sensitive to novel stimuli, sufficient to gain access to memory, while the amygdala to novelty. Yet, their electrophysiological profiles in detecting predictable and unpredictable deviant auditory events remain unknown. Here, we hypothesized that the hippocampus would be sensitive to predictability, while the amygdala to unexpected deviance. We presented epileptic patients undergoing presurgical monitoring with standard and deviant sounds, in predictable or unpredictable contexts. Onsets of auditory responses and unpredictable deviance effects were detected earlier in the temporal cortex compared with the amygdala and hippocampus. Deviance effects in 1\u201320\u00a0Hz local field potentials were detected in the lateral temporal cortex, irrespective of predictability. The amygdala showed stronger deviance in the unpredictable context. Low-frequency deviance responses in the hippocampus (1\u20138\u00a0Hz) were observed in the predictable but not in the unpredictable context. Our results reveal a distributed network underlying the generation of auditory predictions and suggest that the neural basis of sensory predictions and prediction error signals needs to be extended.<\/jats:p>","DOI":"10.1093\/cercor\/bhad532","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T18:22:50Z","timestamp":1703182970000},"source":"Crossref","is-referenced-by-count":10,"title":["Predictable and unpredictable deviance detection in the human hippocampus and amygdala"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7588-1418","authenticated-orcid":false,"given":"Athina","family":"Tzovara","sequence":"first","affiliation":[{"name":"Helen Wills Neuroscience Institute, University of California , 450 Li Ka Shing Biomedical Center, Berkeley, CA 94720-3370 , United States"},{"name":"Institute of Computer Science, University of Bern , Bern, Neubr\u00fcckstrasse 3012 , Switzerland"},{"name":"Center for Experimental Neurology - Sleep Wake Epilepsy Center | NeuroTec , Department of Neurology, Inselspital, Bern University Hospital, , Bern, Freiburgstrasse 3010 , Switzerland"},{"name":"University of Bern , Department of Neurology, Inselspital, Bern University Hospital, , Bern, Freiburgstrasse 3010 , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Fedele","sequence":"additional","affiliation":[{"name":"Neurosurgery Department, University Hospital Z\u00fcrich , Z\u00fcrich, Frauenklinikstrasse 8091 , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Sarnthein","sequence":"additional","affiliation":[{"name":"Neurosurgery Department, University Hospital Z\u00fcrich , Z\u00fcrich, Frauenklinikstrasse 8091 , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debora","family":"Ledergerber","sequence":"additional","affiliation":[{"name":"Swiss Epilepsy Center, Klinik Lengg , Z\u00fcrich, Bleulerstrasse 8008 , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack J","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California , Davis, Folsom Boulevard, Davis, CA 95816 , USA"},{"name":"The Center of Mind and Brain, University of California , Davis, Cousteau Pl, Davis, CA 95618 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert T","family":"Knight","sequence":"additional","affiliation":[{"name":"Helen Wills Neuroscience Institute, University of California , 450 Li Ka Shing Biomedical Center, Berkeley, CA 94720-3370 , United States"},{"name":"Department of Psychology, University of California , Berkeley, CA 94720-1650 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"issue":"40","key":"2024020511100912100_ref1","doi-asserted-by":"crossref","first-page":"8680","DOI":"10.1523\/JNEUROSCI.0369-18.2018","article-title":"Not all predictions are equal: \u201cwhat\u201d and \u201cwhen\u201d predictions modulate activity in auditory cortex through different mechanisms","volume":"38","author":"Auksztulewicz","year":"2018","journal-title":"J Neurosci"},{"issue":"4","key":"2024020511100912100_ref2","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.neuron.2010.02.006","article-title":"Intracranial EEG correlates of expectancy and memory formation in the human hippocampus and nucleus accumbens","volume":"65","author":"Axmacher","year":"2010","journal-title":"Neuron"},{"issue":"5","key":"2024020511100912100_ref3","doi-asserted-by":"crossref","first-page":"e63220","DOI":"10.1371\/journal.pone.0063220","article-title":"The effect of threat on novelty evoked amygdala responses","volume":"8","author":"Balderston","year":"2013","journal-title":"PLoS One"},{"issue":"1521","key":"2024020511100912100_ref4","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1098\/rstb.2008.0321","article-title":"Predictions: a universal principle in the operation of the human brain. Introduction","volume":"364","author":"Bar","year":"2009","journal-title":"Philos Trans R Soc Lond Ser B Biol Sci"},{"issue":"5","key":"2024020511100912100_ref5","doi-asserted-by":"crossref","first-page":"E616","DOI":"10.1073\/pnas.1508523113","article-title":"Brain responses in humans reveal ideal observer-like sensitivity to complex acoustic patterns","volume":"113","author":"Barascud","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"2024020511100912100_ref6","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.neuroimage.2009.12.083","article-title":"A unique role for the human amygdala in novelty detection","volume":"50","author":"Blackford","year":"2010","journal-title":"NeuroImage"},{"key":"2024020511100912100_ref7","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cortex.2019.09.002","article-title":"Auditory deviance detection in the human insula: an intracranial EEG study","volume":"1","author":"Blenkmann","year":"2019","journal-title":"Cortex"},{"issue":"3","key":"2024020511100912100_ref8","doi-asserted-by":"crossref","first-page":"eaav3687","DOI":"10.1126\/sciadv.aav3687","article-title":"Persistent hippocampal neural firing and hippocampal-cortical coupling predict verbal working memory load","volume":"5","author":"Boran","year":"2019","journal-title":"Sci Adv"},{"issue":"7","key":"2024020511100912100_ref9","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1162\/jocn_a_01387","article-title":"A comparison of auditory oddball responses in dorsolateral prefrontal cortex, basolateral amygdala, and auditory cortex of macaque","volume":"31","author":"Camalier","year":"2019","journal-title":"J Cogn Neurosci"},{"issue":"5793","key":"2024020511100912100_ref10","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1126\/science.1128115","article-title":"High gamma power is phase-locked to theta oscillations in human neocortex","volume":"313","author":"Canolty","year":"2006","journal-title":"Science (New York, N.Y.)"},{"issue":"12","key":"2024020511100912100_ref11","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1016\/j.neuropsychologia.2013.03.019","article-title":"Human hippocampal increases in low-frequency power during associative prediction violations","volume":"51","author":"Chen","year":"2013","journal-title":"Neuropsychologia"},{"issue":"27","key":"2024020511100912100_ref12","doi-asserted-by":"crossref","first-page":"11194","DOI":"10.1523\/JNEUROSCI.0114-13.2013","article-title":"Expectation and attention in hierarchical auditory prediction","volume":"33","author":"Chennu","year":"2013","journal-title":"J Neurosci"},{"key":"2024020511100912100_ref13","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.1941-22.2023","article-title":"Intrinsic neural timescales in the temporal lobe support an auditory processing hierarchy","author":"Cusinato","year":"2023","journal-title":"Journal of Neuroscience"},{"issue":"August","key":"2024020511100912100_ref14","doi-asserted-by":"crossref","first-page":"e78677","DOI":"10.7554\/eLife.78677","article-title":"Information flows from hippocampus to auditory cortex during replay of verbal working memory items","volume":"11","author":"Dimakopoulos","year":"2022","journal-title":"elife"},{"issue":"24","key":"2024020511100912100_ref15","doi-asserted-by":"crossref","first-page":"201525030","DOI":"10.1073\/pnas.1525030113","article-title":"Hierarchy of prediction errors for auditory events in human temporal and frontal cortex","volume":"113","author":"D\u00fcrschmid","year":"2016","journal-title":"Proc Natl Acad Sci"},{"issue":"3","key":"2024020511100912100_ref16","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1093\/cercor\/bhu304","article-title":"Sensory deviancy detection measured directly within the human nucleus accumbens","volume":"26","author":"D\u00fcrschmid","year":"2016","journal-title":"Cereb Cortex"},{"issue":"11","key":"2024020511100912100_ref17","doi-asserted-by":"crossref","first-page":"4530","DOI":"10.1093\/cercor\/bhy331","article-title":"Direct evidence for prediction signals in frontal cortex independent of prediction error","volume":"29","author":"D\u00fcrschmid","year":"2018","journal-title":"Cereb Cortex"},{"issue":"6","key":"2024020511100912100_ref18","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.1152\/jn.00324.2005","article-title":"High gamma activity in response to deviant auditory stimuli recorded directly from human cortex","volume":"94","author":"Edwards","year":"2005","journal-title":"J Neurophysiol"},{"issue":"2","key":"2024020511100912100_ref19","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.tics.2012.12.007","article-title":"Memory on time","volume":"17","author":"Eichenbaum","year":"2013","journal-title":"Trends Cogn Sci"},{"key":"2024020511100912100_ref20","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.78904","article-title":"Successor-like representation guides the prediction of future events in human visual cortex and hippocampus","volume":"12","author":"Ekman","year":"2023","journal-title":"elife"},{"key":"2024020511100912100_ref21","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.116705","article-title":"The relation between neuronal firing, local field potentials and hemodynamic activity in the human amygdala in response to aversive dynamic visual stimuli","volume":"213","author":"Fedele","year":"2020","journal-title":"NeuroImage"},{"issue":"2","key":"2024020511100912100_ref22","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.neuroimage.2008.05.018","article-title":"The functional anatomy of the MMN: a DCM study of the roving paradigm","volume":"42","author":"Garrido","year":"2008","journal-title":"NeuroImage"},{"issue":"3","key":"2024020511100912100_ref23","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.clinph.2008.11.029","article-title":"The mismatch negativity: a review of underlying mechanisms","volume":"120","author":"Garrido","year":"2009","journal-title":"Clin Neurophysiol"},{"key":"2024020511100912100_ref24","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.neuroimage.2015.07.016","article-title":"Ventromedial prefrontal cortex drives hippocampal theta oscillations induced by mismatch computations","volume":"120","author":"Garrido","year":"2015","journal-title":"NeuroImage"},{"key":"2024020511100912100_ref24a","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2013.00267","article-title":"MEG and EEG data analysis with MNE-Python","volume":"7","author":"Gramfort","year":"2013","journal-title":"Frontiers in Neuroscience"},{"issue":"4471","key":"2024020511100912100_ref25","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1126\/science.7434000","article-title":"Endogenous potentials generated in the human hippocampal formation and amygdala by infrequent events","volume":"210","author":"Halgren","year":"1980","journal-title":"Science"},{"issue":"4","key":"2024020511100912100_ref26","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/hipo.10196","article-title":"Magnetic fields in the human hippocampal area evoked by a somatosensory oddball task","volume":"14","author":"Hamada","year":"2004","journal-title":"Hippocampus"},{"key":"2024020511100912100_ref27","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.neuroscience.2017.07.061","article-title":"Great expectations: is there evidence for predictive coding in auditory cortex?","volume":"389","author":"Heilbron","year":"2018","journal-title":"Neuroscience"},{"issue":"3","key":"2024020511100912100_ref28","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0167-8760(95)00031-3","article-title":"Magnetic field tomography of cortical and deep processes: examples of \u2018real-time mapping\u2019 of averaged and single trial MEG signals","volume":"20","author":"Ioannides","year":"1995","journal-title":"Int J Psychophysiol"},{"issue":"1","key":"2024020511100912100_ref29","doi-asserted-by":"crossref","first-page":"5959","DOI":"10.1038\/s41598-017-06477-5","article-title":"Human hippocampal pre-activation predicts behavior","volume":"7","author":"Jafarpour","year":"2017","journal-title":"Sci Rep"},{"issue":"12","key":"2024020511100912100_ref30","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1002\/hbm.21397","article-title":"Rhythm evokes action: early processing of metric deviances in expressive music by experts and laymen revealed by ERP source imaging","volume":"33","author":"James","year":"2012","journal-title":"Hum Brain Mapp"},{"key":"2024020511100912100_ref31","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.conb.2014.07.021","article-title":"Intracranial recordings and human memory","volume":"31","author":"Johnson","year":"2015","journal-title":"Curr Opin Neurobiol"},{"issue":"3","key":"2024020511100912100_ref32","doi-asserted-by":"crossref","first-page":"e2004274","DOI":"10.1371\/journal.pbio.2004274","article-title":"Dynamic frontotemporal systems process space and time in working memory","volume":"16","author":"Johnson","year":"2018","journal-title":"PLoS Biol"},{"issue":"5","key":"2024020511100912100_ref33","doi-asserted-by":"crossref","first-page":"051001","DOI":"10.1088\/1741-2552\/abb7a5","article-title":"Insights into human cognition from intracranial EEG: a review of audition, memory, internal cognition, and causality","volume":"17","author":"Johnson","year":"2020","journal-title":"J. Neural Eng., September"},{"issue":"12","key":"2024020511100912100_ref33a","doi-asserted-by":"crossref","DOI":"10.1038\/s41562-019-0717-0","article-title":"Default network and frontoparietal control network theta connectivity supports internal attention","volume":"3","author":"Kam","year":"2019","journal-title":"Nature Human Behaviour"},{"issue":"2","key":"2024020511100912100_ref34","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1093\/cercor\/bhaa262","article-title":"Top\u2013down attentional modulation in human frontal cortex: differential engagement during external and internal attention","volume":"31","author":"Kam","year":"2021","journal-title":"Cereb Cortex"},{"issue":"6597","key":"2024020511100912100_ref35","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/383256a0","article-title":"Contribution of human hippocampal region to novelty detection","volume":"383","author":"Knight","year":"1996","journal-title":"Nature"},{"issue":"12","key":"2024020511100912100_ref36","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1371\/journal.pbio.0040424","article-title":"An unexpected sequence of events: mismatch detection in the human hippocampus","volume":"4","author":"Kumaran","year":"2006","journal-title":"PLoS Biol"},{"key":"2024020511100912100_ref37a","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2012.06.008","article-title":"High-frequency neural activity and human cognition: Past, present and possible future of intracranial EEG research","volume":"98","author":"Lachaux","year":"2012","journal-title":"Progress in Neurobiology"},{"key":"2024020511100912100_ref37","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3389\/fnhum.2015.00505","article-title":"Implicit learning of predictable sound sequences modulates human brain responses at different levels of the auditory hierarchy","volume":"9","author":"Lecaignard","year":"2015","journal-title":"Front Hum Neurosci"},{"issue":"3","key":"2024020511100912100_ref38","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1523\/JNEUROSCI.0601-21.2021","article-title":"Neurocomputational underpinnings of expected surprise","volume":"42","author":"Lecaignard","year":"2022","journal-title":"J Neurosci"},{"issue":"1","key":"2024020511100912100_ref39","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1038\/s41467-023-38571-w","article-title":"Functional specialization and interaction in the amygdala-hippocampus circuit during working memory processing","volume":"14","author":"Li","year":"2023","journal-title":"Nat Commun"},{"key":"2024020511100912100_ref40","first-page":"JN-RM-0398-23","article-title":"Theta-alpha connectivity in the hippocampal-entorhinal circuit predicts working memory load","author":"Li","year":"2023","journal-title":"J Neurosci"},{"issue":"1521","key":"2024020511100912100_ref41","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1098\/rstb.2008.0316","article-title":"Prediction, sequences and the hippocampus","volume":"364","author":"Lisman","year":"2009","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"2024020511100912100_ref42","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.cortex.2016.05.001","article-title":"Convergent evidence for hierarchical prediction networks from human electrocorticography and magnetoencephalography","volume":"82","author":"Phillips","year":"2016","journal-title":"Cortex"},{"issue":"1","key":"2024020511100912100_ref43","doi-asserted-by":"crossref","first-page":"14007","DOI":"10.1038\/s41598-018-32385-3","article-title":"Low-frequency oscillatory correlates of auditory predictive processing in cortical-subcortical networks: a MEG-study","volume":"8","author":"Recasens","year":"2018","journal-title":"Sci Rep"},{"issue":"4","key":"2024020511100912100_ref44","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1093\/brain\/awh442","article-title":"Subdural recordings of the mismatch negativity (MMN) in patients with focal epilepsy","volume":"128","author":"Rosburg","year":"2005","journal-title":"Brain"},{"issue":"17","key":"2024020511100912100_ref45","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/j.cub.2012.06.056","article-title":"Shaping of object representations in the human medial temporal lobe based on temporal regularities","volume":"22","author":"Schapiro","year":"2012","journal-title":"Curr Biol"},{"key":"2024020511100912100_ref46","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2013291117","article-title":"Statistical prediction of the future impairs episodic encoding of the present","volume":"117","author":"Sherman","year":"2020","journal-title":"PNAS"},{"key":"2024020511100912100_ref46a","doi-asserted-by":"crossref","DOI":"10.1038\/s41596-018-0009-6","article-title":"Integrated analysis of anatomical and electrophysiological human intracranial data","volume":"13","author":"Stolk","year":"2018","journal-title":"Nature Protocols"},{"issue":"August","key":"2024020511100912100_ref47","doi-asserted-by":"crossref","first-page":"702520","DOI":"10.3389\/fnhum.2021.702520","article-title":"Automatic sensory predictions: a review of predictive mechanisms in the brain and their link to conscious processing","volume":"15","author":"Tivadar","year":"2021","journal-title":"Front Hum Neurosci"},{"issue":"14","key":"2024020511100912100_ref48","doi-asserted-by":"crossref","first-page":"4114","DOI":"10.1002\/hbm.24689","article-title":"High-precision magnetoencephalography for reconstructing amygdalar and hippocampal oscillations during prediction of safety and threat","volume":"40","author":"Tzovara","year":"2019","journal-title":"Hum Brain Mapp"}],"container-title":["Cerebral Cortex"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cercor\/article-pdf\/34\/2\/bhad532\/56572859\/bhad532.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cercor\/article-pdf\/34\/2\/bhad532\/56572859\/bhad532.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T06:22:56Z","timestamp":1707114176000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cercor\/article\/doi\/10.1093\/cercor\/bhad532\/7517671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,12]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,1,31]]}},"URL":"https:\/\/doi.org\/10.1093\/cercor\/bhad532","relation":{},"ISSN":["1047-3211","1460-2199"],"issn-type":[{"value":"1047-3211","type":"print"},{"value":"1460-2199","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,2]]},"published":{"date-parts":[[2024,1,12]]},"article-number":"bhad532"}}