{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:06:55Z","timestamp":1791547615600,"version":"4.3.4"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870946"],"award-info":[{"award-number":["81870946"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2108085MH271"],"award-info":[{"award-number":["2108085MH271"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Research and Development Plan Projects of Anhui Province","award":["202104j07020049"],"award-info":[{"award-number":["202104j07020049"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study aimed to explore the topographic features of thalamic subregions, functional connectomes and hierarchical organizations between thalamus and cortex in poststroke fatigue patients. We consecutively recruited 121 acute ischemic stroke patients (mean age: 59\u00a0years) and 46 healthy controls matched for age, sex, and educational level. The mean age was 59\u00a0years (range 19\u201380) and 38% of acute stroke patients were females. Resting-state functional and structural magnetic resonance imaging were conducted on all participants. The fatigue symptoms were measured using the Fatigue Severity Scale. The thalamic functional subdivisions corresponding to the canonical functional network were defined using the winner-take-all parcellation method. Thalamic functional gradients were derived using the diffusion embedding analysis. The results suggested abnormal functional connectivity of thalamic subregions primarily located in the temporal lobe, posterior cingulate gyrus, parietal lobe, and precuneus. The thalamus showed a gradual increase from the medial to the lateral in all groups, but the right thalamus shifted more laterally in poststroke fatigue patients than in non- poststroke fatigue patients. Poststroke fatigue patients also had higher gradient scores in the somatomotor network and the right medial prefrontal and premotor thalamic regions, but lower values in the right lateral prefrontal thalamus. The findings suggested that poststroke fatigue patients had altered functional connectivity and thalamocortical hierarchical organizations, providing new insights into the neural mechanisms of the thalamus.<\/jats:p>","DOI":"10.1093\/cercor\/bhad534","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T03:46:38Z","timestamp":1705031198000},"source":"Crossref","is-referenced-by-count":8,"title":["Functional connectome hierarchy of thalamus impacts fatigue in acute stroke patients"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8182-9632","authenticated-orcid":false,"given":"Jinjing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology , Nanjing Jinling Hospital, Affiliated Hospital of Medical School, , Nanjing 210093 , China"},{"name":"Nanjing University , Nanjing Jinling Hospital, Affiliated Hospital of Medical School, , Nanjing 210093 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre for Leading Medicine and Advanced Technologies of IHM, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei, Anhui 230001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yirong","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre for Leading Medicine and Advanced Technologies of IHM, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei, Anhui 230001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre for Leading Medicine and Advanced Technologies of IHM, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei, Anhui 230001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre for Leading Medicine and Advanced Technologies of IHM, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei, Anhui 230001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Neurology , Nanjing Jinling Hospital, Affiliated Hospital of Medical School, , Nanjing 210093 , China"},{"name":"Nanjing University , Nanjing Jinling Hospital, Affiliated Hospital of Medical School, , Nanjing 210093 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre for Leading Medicine and Advanced Technologies of IHM, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei, Anhui 230001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Radiology , the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, , Hefei 230036 , China"},{"name":"University of Science and Technology of China , the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, , Hefei 230036 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology , the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, , Hefei 230036 , China"},{"name":"University of Science and Technology of China , the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, , Hefei 230036 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre for Leading Medicine and Advanced Technologies of IHM, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei, Anhui 230001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinfeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology , Nanjing Jinling Hospital, Affiliated Hospital of Medical School, , Nanjing 210093 , China"},{"name":"Nanjing University , Nanjing Jinling Hospital, Affiliated Hospital of Medical School, , Nanjing 210093 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,11]]},"reference":[{"issue":"11","key":"2024020511092113000_ref1","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1002\/hbm.22124","article-title":"The centre of the brain: topographical model of motor, cognitive, affective, and somatosensory functions of the basal ganglia","volume":"34","author":"Arsalidou","year":"2013","journal-title":"Hum Brain Mapp"},{"key":"2024020511092113000_ref2","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.nicl.2016.03.016","article-title":"Connectivity-based parcellation increases network detection sensitivity in resting state fMRI: an investigation into the cingulate cortex in autism","volume":"11","author":"Balsters","year":"2016","journal-title":"Neuroimage Clin"},{"issue":"7","key":"2024020511092113000_ref3","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nn1075","article-title":"Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging","volume":"6","author":"Behrens","year":"2003","journal-title":"Nat Neurosci"},{"issue":"4","key":"2024020511092113000_ref4","doi-asserted-by":"crossref","first-page":"e1851","DOI":"10.1002\/pri.1851","article-title":"Fatigue and activity after stroke. Secondary results from the life after stroke study","volume":"25","author":"Braaten","year":"2020","journal-title":"Physiother Res Int"},{"key":"2024020511092113000_ref5","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/bs.pbr.2015.03.005","article-title":"Importance of the ventral midline thalamus in driving hippocampal functions","volume":"219","author":"Cassel","year":"2015","journal-title":"Prog Brain Res"},{"key":"2024020511092113000_ref6","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.nicl.2015.08.021","article-title":"Regional vulnerability of longitudinal cortical association connectivity: associated with structural network topology alterations in preterm children with cerebral palsy","volume":"9","author":"Ceschin","year":"2015","journal-title":"Neuroimage Clin"},{"issue":"5","key":"2024020511092113000_ref7","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.3390\/jcm11051430","article-title":"Comparison of long-term outcomes and associated factors between younger and older rural ischemic stroke patients","volume":"11","author":"Chaudhary","year":"2022","journal-title":"J Clin Med"},{"key":"2024020511092113000_ref8","doi-asserted-by":"crossref","first-page":"709","DOI":"10.3389\/fnhum.2014.00709","article-title":"Examining the role of the temporo-parietal network in memory, imagery, and viewpoint transformations","volume":"8","author":"Dhindsa","year":"2014","journal-title":"Front Hum Neurosci"},{"key":"2024020511092113000_ref9","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.schres.2016.08.007","article-title":"Postmortem structural studies of the thalamus in schizophrenia","volume":"180","author":"Dorph-Petersen","year":"2017","journal-title":"Schizophr Res"},{"issue":"8","key":"2024020511092113000_ref10","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.1093\/cercor\/bhw157","article-title":"The Human Brainnetome Atlas: a new brain atlas based on connectional architecture","volume":"26","author":"Fan","year":"2016","journal-title":"Cereb Cortex"},{"issue":"4","key":"2024020511092113000_ref11","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/jon.12723","article-title":"Functional connectivity and structural disruption in the default-mode network predicts cognitive rehabilitation outcomes in multiple sclerosis","volume":"30","author":"Fuchs","year":"2020","journal-title":"J Neuroimaging"},{"issue":"3","key":"2024020511092113000_ref12","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/hbm.23915","article-title":"Structural connectivity of the amygdala in young adults with autism spectrum disorder","volume":"39","author":"Gibbard","year":"2018","journal-title":"Hum Brain Mapp"},{"issue":"4","key":"2024020511092113000_ref13","doi-asserted-by":"crossref","first-page":"e00943","DOI":"10.1002\/brb3.943","article-title":"Thalamic functional connectivity and its association with behavioral performance in older age","volume":"8","author":"Goldstone","year":"2018","journal-title":"Brain Behav"},{"issue":"3","key":"2024020511092113000_ref14","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1089\/brain.2013.0146","article-title":"Functional connectivity within the default mode network is associated with saccadic accuracy in Parkinson's disease: a resting-state FMRI and videooculographic study","volume":"3","author":"Gorges","year":"2013","journal-title":"Brain Connect"},{"key":"2024020511092113000_ref15","doi-asserted-by":"crossref","first-page":"e36652","DOI":"10.7554\/eLife.36652","article-title":"Functional gradients of the cerebellum","volume":"7","author":"Guell","year":"2018","journal-title":"elife"},{"issue":"5","key":"2024020511092113000_ref16","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.neuron.2019.06.005","article-title":"Thalamocortical circuit motifs: a general framework","volume":"103","author":"Halassa","year":"2019","journal-title":"Neuron"},{"issue":"7781","key":"2024020511092113000_ref17","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s41586-019-1716-z","article-title":"Hierarchical organization of cortical and thalamic connectivity","volume":"575","author":"Harris","year":"2019","journal-title":"Nature"},{"issue":"12","key":"2024020511092113000_ref19","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1162\/jocn_a_01628","article-title":"Network localization of executive function deficits in patients with focal thalamic lesions","volume":"32","author":"Hwang","year":"2020","journal-title":"J Cogn Neurosci"},{"issue":"7554","key":"2024020511092113000_ref20","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature14396","article-title":"A prefrontal-thalamo-hippocampal circuit for goal-directed spatial navigation","volume":"522","author":"Ito","year":"2015","journal-title":"Nature"},{"issue":"6","key":"2024020511092113000_ref21","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1002\/hbm.21517","article-title":"Functional connectivity-based identification of subdivisions of the basal ganglia and thalamus using multilevel independent component analysis of resting state fMRI","volume":"34","author":"Kim","year":"2013","journal-title":"Hum Brain Mapp"},{"issue":"8","key":"2024020511092113000_ref22","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1093\/brain\/awx153","article-title":"The fatigue conundrum","volume":"140","author":"Kuppuswamy","year":"2017","journal-title":"Brain"},{"issue":"6","key":"2024020511092113000_ref23","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1177\/1747493019847334","article-title":"Canadian stroke best practice recommendations: mood, cognition and fatigue following stroke, 6th edition update 2019","volume":"15","author":"Lanctot","year":"2020","journal-title":"Int J Stroke"},{"issue":"44","key":"2024020511092113000_ref24","doi-asserted-by":"crossref","first-page":"12574","DOI":"10.1073\/pnas.1608282113","article-title":"Situating the default-mode network along a principal gradient of macroscale cortical organization","volume":"113","author":"Margulies","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024020511092113000_ref25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.conb.2016.05.003","article-title":"From regions to connections and networks: new bridges between brain and behavior","volume":"40","author":"Misic","year":"2016","journal-title":"Curr Opin Neurobiol"},{"issue":"11","key":"2024020511092113000_ref26","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110523","article-title":"Beyond body maps: information content of specific body parts is distributed across the somatosensory homunculus","volume":"38","author":"Muret","year":"2022","journal-title":"Cell Rep"},{"issue":"3","key":"2024020511092113000_ref27","doi-asserted-by":"crossref","first-page":"e002404","DOI":"10.1136\/bmjopen-2012-002404","article-title":"Poststroke fatigue and depression are related to mortality in young adults: a cohort study","volume":"3","author":"Naess","year":"2013","journal-title":"BMJ Open"},{"issue":"4","key":"2024020511092113000_ref28","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3390\/brainsci10040247","article-title":"The supplementary motor area responsible for word retrieval decline after acute thalamic stroke revealed by coupled SPECT and near-infrared spectroscopy","volume":"10","author":"Obayashi","year":"2020","journal-title":"Brain Sci"},{"issue":"8","key":"2024020511092113000_ref29","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.biopsych.2017.11.008","article-title":"The Mediodorsal thalamus: an essential partner of the prefrontal cortex for cognition","volume":"83","author":"Parnaudeau","year":"2018","journal-title":"Biol Psychiatry"},{"key":"2024020511092113000_ref31","volume-title":"Neuroanatomy, thalamic nuclei","author":"Sheridan","year":"2023"},{"issue":"4","key":"2024020511092113000_ref32","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nn.4269","article-title":"Thalamus plays a central role in ongoing cortical functioning","volume":"19","author":"Sherman","year":"2016","journal-title":"Nat Neurosci"},{"key":"2024020511092113000_ref33","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.pscychresns.2016.04.013","article-title":"Pharmacological modulation of pulvinar resting-state regional oscillations and network dynamics in major depression","volume":"252","author":"Tadayonnejad","year":"2016","journal-title":"Psychiatry Res Neuroimaging"},{"key":"2024020511092113000_ref34","volume-title":"Neuroanatomy, thalamus","author":"Torrico","year":"2023"},{"key":"2024020511092113000_ref18","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/978-3-030-58505-1_12","volume-title":"Clinical pathways in stroke rehabilitation: evidence-based clinical practice recommendations","author":"Heugten","year":"2021"},{"issue":"1","key":"2024020511092113000_ref30","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1159\/000095757","article-title":"Is fatigue an independent factor associated with activities of daily living, instrumental activities of daily living and health-related quality of life in chronic stroke?","volume":"23","author":"Port","year":"2007","journal-title":"Cerebrovasc Dis"},{"issue":"40","key":"2024020511092113000_ref35","doi-asserted-by":"crossref","first-page":"10154","DOI":"10.1073\/pnas.1803667115","article-title":"Anatomical and microstructural determinants of hippocampal subfield functional connectome embedding","volume":"115","author":"Vos de Wael","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"2024020511092113000_ref36","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s42003-020-0794-7","article-title":"BrainSpace: a toolbox for the analysis of macroscale gradients in neuroimaging and connectomics datasets","volume":"3","author":"Vos de Wael","year":"2020","journal-title":"Commun Biol"},{"issue":"1","key":"2024020511092113000_ref37","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11136-015-1056-x","article-title":"Cultural adaptation and validation of the Chinese version of the fatigue severity scale in patients with major depressive disorder and nondepressive people","volume":"25","author":"Wang","year":"2016","journal-title":"Qual Life Res"},{"issue":"21","key":"2024020511092113000_ref38","doi-asserted-by":"crossref","first-page":"e1971","DOI":"10.1212\/WNL.0000000000006534","article-title":"Depressed TSH level as a predictor of poststroke fatigue in patients with acute ischemic stroke","volume":"91","author":"Wang","year":"2018","journal-title":"Neurology"},{"key":"2024020511092113000_ref39","doi-asserted-by":"crossref","first-page":"902604","DOI":"10.3389\/fnagi.2022.902604","article-title":"Association of lesion location and fatigue symptoms after ischemic stroke: a VLSM study","volume":"14","author":"Wang","year":"2022","journal-title":"Front Aging Neurosci"},{"issue":"2","key":"2024020511092113000_ref40","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00415-015-7958-2","article-title":"Factors associated with post-stroke depression and fatigue: lesion location and coping styles","volume":"263","author":"Wei","year":"2016","journal-title":"J Neurol"},{"issue":"1","key":"2024020511092113000_ref41","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1523\/JNEUROSCI.0479-18.2018","article-title":"The cognitive thalamus as a gateway to mental representations","volume":"39","author":"Wolff","year":"2019","journal-title":"J Neurosci"},{"issue":"12","key":"2024020511092113000_ref42","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.biopsych.2015.06.026","article-title":"Mapping Thalamocortical functional connectivity in chronic and early stages of psychotic disorders","volume":"79","author":"Woodward","year":"2016","journal-title":"Biol Psychiatry"},{"issue":"1","key":"2024020511092113000_ref43","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/schbul\/sbab086","article-title":"Imbalance between Prefronto-thalamic and sensorimotor-thalamic circuitries associated with working memory deficit in schizophrenia","volume":"48","author":"Wu","year":"2022","journal-title":"Schizophr Bull"},{"issue":"5","key":"2024020511092113000_ref44","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s10548-023-00975-8","article-title":"Electroencephalography-derived functional connectivity in sensorimotor networks in post stroke fatigue","volume":"36","author":"Wu","year":"2023","journal-title":"Brain Topogr"},{"key":"2024020511092113000_ref45","doi-asserted-by":"crossref","first-page":"116960","DOI":"10.1016\/j.neuroimage.2020.116960","article-title":"The thalamic functional gradient and its relationship to structural basis and cognitive relevance","volume":"218","author":"Yang","year":"2020","journal-title":"NeuroImage"},{"issue":"1","key":"2024020511092113000_ref46","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1038\/s41467-022-28892-7","article-title":"Medial prefrontal cortex and anteromedial thalamus interaction regulates goal-directed behavior and dopaminergic neuron activity","volume":"13","author":"Yang","year":"2022","journal-title":"Nat Commun"},{"issue":"3","key":"2024020511092113000_ref47","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1152\/jn.00338.2011","article-title":"The organization of the human cerebral cortex estimated by intrinsic functional connectivity","volume":"106","author":"Yeo","year":"2011","journal-title":"J Neurophysiol"},{"issue":"4","key":"2024020511092113000_ref48","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1007\/s00429-015-1018-7","article-title":"Functional topography of the thalamocortical system in human","volume":"221","author":"Yuan","year":"2016","journal-title":"Brain Struct Funct"}],"container-title":["Cerebral Cortex"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cercor\/article-pdf\/34\/2\/bhad534\/56572670\/bhad534.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cercor\/article-pdf\/34\/2\/bhad534\/56572670\/bhad534.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T11:19:33Z","timestamp":1707131973000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cercor\/article\/doi\/10.1093\/cercor\/bhad534\/7516936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,11]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,1,31]]}},"URL":"https:\/\/doi.org\/10.1093\/cercor\/bhad534","relation":{},"ISSN":["1047-3211","1460-2199"],"issn-type":[{"value":"1047-3211","type":"print"},{"value":"1460-2199","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,2]]},"published":{"date-parts":[[2024,1,11]]},"article-number":"bhad534"}}