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Thirty-one children with IGE and 31 age-matched healthy controls (HC) were recruited. Structural magnetic resonance imaging (sMRI) data were acquired, and voxel-based morphometry (VBM) analysis were performed to reveal abnormal gray matter volume (GMV). Moreover, sFC and dFC analyses were conducted using the brain areas exhibiting abnormal GMV as seed regions to explore abnormal functional couplings. Compared to HC, the IGE group exhibited increased GMV in left middle cingulate cortex (MCC) and right parahippocampus (ParaHipp). In addition, the analyses of dFC and sFC with MCC and ParaHipp as seeds revealed more extensive functional connectivity (FC) changes in dFC. Notably, the structurally and functionally abnormal brain areas were primarily localized in the default mode network (DMN). However, our study did not find any significant associations between these altered neuroimaging measurements and clinical outcomes. This study uncovered microstructural changes as well as corresponding sFC and dFC changes in patients with new-onset, untreated pediatric IGE. The affected brain regions were primarily located within the DMN, highlighting the DMN\u2019s crucial role in the development of pediatric IGE.<\/jats:p>","DOI":"10.1093\/cercor\/bhae021","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T10:08:06Z","timestamp":1707127686000},"source":"Crossref","is-referenced-by-count":9,"title":["Structural and functional abnormalities in first-episode drug-na\u00efve pediatric idiopathic generalized epilepsy"],"prefix":"10.1093","volume":"34","author":[{"given":"Dingmei","family":"Deng","sequence":"first","affiliation":[{"name":"West China School of Public Health and West China Fourth Hospital, Sichuan University , No. 18, South Section 3, First Ring Road, Wuhou District, Chengdu 610041 , China"},{"name":"Medical Imaging Center, The Second People\u2019s Hospital of Yibin , 96# Beida Street, Cuiping District, Yibin 644000 , China"},{"name":"Clinical Research and Translational Center , Second People's Hospital of Yibin City-West China Yibin Hospital, , 96# Beida Street, Cuiping District, Yibin 644000 , China"},{"name":"Sichuan University , Second People's Hospital of Yibin City-West China Yibin Hospital, , 96# Beida Street, Cuiping District, Yibin 644000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Electrical Engineering, Sichuan University , No. 24, South Section 1, First Ring Road, Wuhou District, Chengdu 610065 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical Imaging Center, The Second People\u2019s Hospital of Yibin , 96# Beida Street, Cuiping District, Yibin 644000 , China"},{"name":"Clinical Research and Translational Center , Second People's Hospital of Yibin City-West China Yibin Hospital, , 96# Beida Street, Cuiping District, Yibin 644000 , China"},{"name":"Sichuan University , Second People's Hospital of Yibin City-West China Yibin Hospital, , 96# Beida Street, Cuiping District, Yibin 644000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Guo","sequence":"additional","affiliation":[{"name":"Medical Imaging Center, The Second People\u2019s Hospital of Yibin , 96# Beida Street, Cuiping District, Yibin 644000 , China"},{"name":"Clinical Research and Translational Center , Second People's Hospital of Yibin City-West China Yibin Hospital, , 96# Beida Street, Cuiping District, Yibin 644000 , China"},{"name":"Sichuan University , Second People's Hospital of Yibin City-West China Yibin Hospital, , 96# Beida Street, Cuiping District, Yibin 644000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhi","family":"Yuan","sequence":"additional","affiliation":[{"name":"Medical Imaging Center, The Second People\u2019s Hospital of Yibin , 96# Beida Street, Cuiping District, Yibin 644000 , China"},{"name":"Clinical Research and Translational Center , Second People's Hospital of Yibin City-West China Yibin Hospital, , 96# Beida Street, Cuiping District, Yibin 644000 , China"},{"name":"Sichuan University , Second People's Hospital of Yibin City-West China Yibin Hospital, , 96# Beida Street, Cuiping District, Yibin 644000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaojian","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Primate Biomedical Research , Institute of Primate Translational Medicine, , No.7, Zhiyuan Road, Chenggong District, Kunming 650500 , China"},{"name":"Kunming University of Science and Technology , Institute of Primate Translational Medicine, , No.7, Zhiyuan Road, Chenggong District, Kunming 650500 , China"},{"name":"Yunnan Key Laboratory of Primate Biomedical Research , No.7, Zhiyuan Road, Chenggong District, Kunming 650500 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Qiu","sequence":"additional","affiliation":[{"name":"Medical Imaging Center, The Second People\u2019s Hospital of Yibin , 96# Beida Street, Cuiping District, Yibin 644000 , China"},{"name":"Clinical Research and Translational Center , Second People's Hospital of Yibin City-West China Yibin Hospital, , 96# Beida Street, Cuiping District, Yibin 644000 , China"},{"name":"Sichuan University , Second People's Hospital of Yibin City-West China Yibin Hospital, , 96# Beida Street, Cuiping District, Yibin 644000 , China"},{"name":"Functional and Molecular Imaging Key Laboratory of Sichuan Province , No. 24, South Section 1, First Ring Road, Wuhou District, Chengdu City, Sichuan Province, Chengdu 610065 , 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