{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:23:55Z","timestamp":1790771035639,"version":"4.1.0"},"reference-count":104,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Deutsche Forschungsgemeinschaft (DFG) Cluster of Excellence, Research Center \u201cNanoscale Microscopy and Molecular Physiology of the Brain\u201d","award":["Sta 431\/11-2"],"award-info":[{"award-number":["Sta 431\/11-2"]}]},{"name":"Deutsche Forschungsgemeinschaft (DFG) Cluster of Excellence, Research Center \u201cNanoscale Microscopy and Molecular Physiology of the Brain\u201d","award":["Wa 3783\/1"],"award-info":[{"award-number":["Wa 3783\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In mammalian neocortex development, every cohort of newborn neurons is guided toward the marginal zone, leading to an \u201cinside-out\u201d organization of the 6 neocortical layers. This migratory pattern is regulated by the extracellular glycoprotein Reelin. The reeler mouse shows a homozygous mutation of the reelin gene. Using RNA in situ hybridization we could demonstrate that the Reelin-deficient mouse cortex (male and female) displays an increasing lamination defect along the rostro-caudal axis that is characterized by strong cellular intermingling, but roughly reproduces the \u201cinside-out\u201d pattern in rostral cortex, while caudal cortex shows a relative inversion of neuronal positioning (\u201coutside-in\u201d). We found that in development of the reeler cortex, preplate-splitting is also defective with an increasing severity along the rostro-caudal axis. This leads to a misplacement of subplate neurons that are crucial for a switch in migration mode within the cortical plate. Using Flash Tag labeling and nucleoside analog pulse-chasing, we found an according migration defect within the cortical plate, again with a progressive severity along the rostro-caudal axis. Thus, loss of one key player in neocortical development leads to highly area-specific (caudally pronounced) developmental deficiencies that result in multiple roughly opposite rostral versus caudal adult neocortical phenotypes.<\/jats:p>","DOI":"10.1093\/cercor\/bhae023","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T01:51:56Z","timestamp":1708566716000},"source":"Crossref","is-referenced-by-count":3,"title":["Caudally pronounced deficiencies in preplate splitting and migration underly a rostro-caudal progression of cortical lamination defects in the <i>reeler<\/i> brain"],"prefix":"10.1093","volume":"34","author":[{"given":"Nieves","family":"Mingo-Moreno","sequence":"first","affiliation":[{"name":"Institute for Neuroanatomy, University Medical Center G\u00f6ttingen , G\u00f6ttingen 37075 , Germany"},{"name":"Center for Nanoscale Microscopy and Molecular Physiology of the Brain , G\u00f6ttingen 37073 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Truschow","sequence":"additional","affiliation":[{"name":"Institute for Neuroanatomy, University Medical Center G\u00f6ttingen , G\u00f6ttingen 37075 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5694-9723","authenticated-orcid":false,"given":"Jochen F","family":"Staiger","sequence":"additional","affiliation":[{"name":"Institute for Neuroanatomy, University Medical Center G\u00f6ttingen , G\u00f6ttingen 37075 , Germany"},{"name":"Center for Nanoscale Microscopy and Molecular Physiology of the Brain , G\u00f6ttingen 37073 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8762-833X","authenticated-orcid":false,"given":"Robin J","family":"Wagener","sequence":"additional","affiliation":[{"name":"Institute for Neuroanatomy, University Medical Center G\u00f6ttingen , G\u00f6ttingen 37075 , Germany"},{"name":"Department of Neurology, University Hospital Heidelberg , Heidelberg 69120 , Germany"},{"name":"Clinical Cooperation Unit Neurooncology, German Cancer Research Center (DKFZ) , Heidelberg 69120 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"issue":"3","key":"2024022201515332000_ref1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/980","article-title":"Loss of adenylyl cyclase I activity disrupts patterning of mouse somatosensory cortex","volume":"19","author":"Abdel-Majid","year":"1998","journal-title":"Nat Genet"},{"issue":"31","key":"2024022201515332000_ref2","doi-asserted-by":"crossref","first-page":"9355","DOI":"10.1021\/bi034475p","article-title":"Differential binding of ligands to the apolipoprotein E receptor 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