{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:46:29Z","timestamp":1753875989879,"version":"3.41.2"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS106030","R01EB031849","R01EB032366","R01HD109395","R01EB032708","R01HD100009","R03DE022109","S10OD025111"],"award-info":[{"award-number":["R01NS106030","R01EB031849","R01EB032366","R01HD109395","R01EB032708","R01HD100009","R03DE022109","S10OD025111"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cleft lip\/palate is a common orofacial malformation that often leads to speech\/language difficulties as well as developmental delays in affected children, despite surgical repair. Our understanding of brain development in these children is limited. This study aimed to analyze prenatal brain development in fetuses with cleft lip\/palate and controls. We examined in utero MRIs of 30 controls and 42 cleft lip\/palate fetal cases and measured regional brain volumes. Cleft lip\/palate was categorized into groups A (cleft lip or alveolus) and B (any combination of clefts involving the primary and secondary palates). Using a repeated-measures regression model with relative brain hemisphere volumes (%), and after adjusting for multiple comparisons, we did not identify significant differences in regional brain growth between group A and controls. Group B clefts had significantly slower weekly cerebellar growth compared with controls. We also observed divergent brain growth in transient brain structures (cortical plate, subplate, ganglionic eminence) within group B clefts, depending on severity (unilateral or bilateral) and defect location (hemisphere ipsilateral or contralateral to the defect). Further research is needed to explore the association between regional fetal brain growth and cleft lip\/palate severity, with the potential to inform early neurodevelopmental biomarkers and personalized diagnostics.<\/jats:p>","DOI":"10.1093\/cercor\/bhae024","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T23:24:02Z","timestamp":1708125842000},"source":"Crossref","is-referenced-by-count":0,"title":["Divergent growth of the transient brain compartments in fetuses with nonsyndromic isolated clefts involving the primary and secondary palate"],"prefix":"10.1093","volume":"34","author":[{"given":"Olivia","family":"Masse","sequence":"first","affiliation":[{"name":"Division of Newborn Medicine, Boston Children\u2019s Hospital and Harvard Medical School , Boston, MA 02115 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Brumfield","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Boston Children\u2019s Hospital and Harvard Medical School , Boston, MA 02115 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esha","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Boston Children\u2019s Hospital and Harvard Medical School , Boston, MA 02115 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemente","family":"Velasco-Annis","sequence":"additional","affiliation":[{"name":"Department of Radiology, Boston Children\u2019s Hospital and Harvard Medical School , Boston, MA 02115 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennings","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Boston Children\u2019s Hospital and Harvard Medical School , Boston, MA 02115 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin K","family":"Rollins","sequence":"additional","affiliation":[{"name":"Department of Neurology Medicine, Boston Children\u2019s Hospital and Harvard Medical School , Boston, MA 02115 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Connolly","sequence":"additional","affiliation":[{"name":"Department of Radiology, Boston Children\u2019s Hospital and Harvard Medical School , Boston, MA 02115 , United States"},{"name":"Maternal Fetal Care Center, Boston Children\u2019s Hospital , Boston, MA 02115 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Barnewolt","sequence":"additional","affiliation":[{"name":"Department of Radiology, Boston Children\u2019s Hospital and Harvard Medical School , Boston, MA 02115 , United States"},{"name":"Maternal Fetal Care Center, Boston Children\u2019s Hospital , Boston, MA 02115 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza A","family":"Shamshirsaz","sequence":"additional","affiliation":[{"name":"Maternal Fetal Care Center, Boston Children\u2019s Hospital , Boston, MA 02115 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shohra","family":"Qaderi","sequence":"additional","affiliation":[{"name":"Maternal Fetal Care Center, Boston Children\u2019s Hospital , Boston, MA 02115 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Javinani","sequence":"additional","affiliation":[{"name":"Maternal Fetal Care Center, Boston Children\u2019s Hospital , Boston, MA 02115 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon K","family":"Warfield","sequence":"additional","affiliation":[{"name":"Department of Radiology, Boston Children\u2019s Hospital and Harvard Medical School , Boston, MA 02115 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Boston Children\u2019s Hospital and Harvard Medical School , Boston, MA 02115 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Gholipour","sequence":"additional","affiliation":[{"name":"Department of Radiology, Boston Children\u2019s Hospital and Harvard Medical School , Boston, MA 02115 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry A","family":"Feldman","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Boston Children\u2019s Hospital and Harvard Medical School , Boston, MA 02115 , United States"},{"name":"Institutional Centers for Clinical and Translational Research, Boston Children\u2019s Hospital and Harvard Medical School , Boston, MA 02115 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia E","family":"Grant","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Boston Children\u2019s Hospital and Harvard Medical School , Boston, MA 02115 , United States"},{"name":"Department of Radiology, Boston Children\u2019s Hospital and Harvard Medical School , Boston, MA 02115 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John B","family":"Mulliken","sequence":"additional","affiliation":[{"name":"Department of Plastic and Oral Surgery, Boston Children\u2019s Hospital and Harvard Medical School , Boston, MA 02115 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lana","family":"Pierotich","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Boston Children\u2019s Hospital and Harvard Medical School , Boston, MA 02115 , United 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