{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:46:01Z","timestamp":1790221561569,"version":"4.1.0"},"reference-count":85,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100001454","name":"American Epilepsy Society","doi-asserted-by":"publisher","award":["PT0035"],"award-info":[{"award-number":["PT0035"]}],"id":[{"id":"10.13039\/100001454","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH1810699"],"award-info":[{"award-number":["W81XWH1810699"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH2210769"],"award-info":[{"award-number":["W81XWH2210769"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Neurological Disease and Stroke","award":["R21NS098009"],"award-info":[{"award-number":["R21NS098009"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Traumatic brain injury (TBI) is the leading cause of death in young people and can cause cognitive and motor dysfunction and disruptions in functional connectivity between brain regions. In human TBI patients and rodent models of TBI, functional connectivity is decreased after injury. Recovery of connectivity after TBI is associated with improved cognition and memory, suggesting an important link between connectivity and functional outcome. We examined widespread alterations in functional connectivity following TBI using simultaneous widefield mesoscale GCaMP7c calcium imaging and electrocorticography (ECoG) in mice injured using the controlled cortical impact (CCI) model of TBI. Combining CCI with widefield cortical imaging provides us with unprecedented access to characterize network connectivity changes throughout the entire injured cortex over time. Our data demonstrate that CCI profoundly disrupts functional connectivity immediately after injury, followed by partial recovery over 3\u00a0weeks. Examining discrete periods of locomotion and stillness reveals that CCI alters functional connectivity and reduces theta power only during periods of behavioral stillness. Together, these findings demonstrate that TBI causes dynamic, behavioral state-dependent changes in functional connectivity and ECoG activity across the cortex.<\/jats:p>","DOI":"10.1093\/cercor\/bhae038","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T15:38:46Z","timestamp":1705937926000},"source":"Crossref","is-referenced-by-count":10,"title":["Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5966-1004","authenticated-orcid":false,"given":"Samantha","family":"Bottom-Tanzer","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Tufts University School of Medicine , Boston, MA 02111 ,","place":["United States"]},{"name":"MD\/PhD Program, Tufts University School of Medicine , Boston, MA 02111 ,","place":["United States"]},{"name":"Neuroscience Program, Tufts Graduate School of Biomedical Sciences , Boston, MA 02111 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Corella","sequence":"additional","affiliation":[{"name":"Department of Pathology, Case Western Reserve University School of Medicine , Cleveland, OH 44106 ,","place":["United States"]},{"name":"MD\/PhD Program, Case Western Reserve University School of Medicine , Cleveland, OH 44106 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Baylor College of Medicine , Houston, TX 77030 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Sommer","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Tufts University School of Medicine , Boston, MA 02111 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Bola\u00f1os","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of British Columbia , Vancouver, British Columbia, V6T 1Z4 ,","place":["Canada"]},{"name":"Djavad Mowafaghian Centre for Brain Health, University of British Columbia , Vancouver, British Columbia , V6T 1Z4","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of British Columbia , Vancouver, British Columbia, V6T 1Z4 ,","place":["Canada"]},{"name":"Djavad Mowafaghian Centre for Brain Health, University of British Columbia , Vancouver, British Columbia , V6T 1Z4","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadi","family":"Qui\u00f1ones","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Tufts University School of Medicine , Boston, MA 02111 ,","place":["United States"]},{"name":"Neuroscience Program, Tufts Graduate School of Biomedical Sciences , Boston, MA 02111 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane","family":"Heiney","sequence":"additional","affiliation":[{"name":"Iowa Neuroscience Institute, University of Iowa , Iowa City, IA 52242 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Shtrahman","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of California San Diego , La Jolla, CA 92093 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Whalen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Harvard Medical School, Massachusetts General Hospital , Boston, MA 02115 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Oren","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Kavli Institute for Neuroscience, Yale School of Medicine , New Haven, CT 06510 ,","place":["United States"]},{"name":"Interdepartmental Neuroscience Program, Yale School of Medicine , New Haven, CT 06510 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Higley","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Kavli Institute for Neuroscience, Yale School of Medicine , New Haven, CT 06510 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A","family":"Cardin","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Kavli Institute for Neuroscience, Yale School of Medicine , New Haven, CT 06510 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzad","family":"Noubary","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Northeastern University , Boston, MA 02115 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Armbruster","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Tufts University School of Medicine , Boston, MA 02111 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Dulla","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Tufts University School of Medicine , Boston, MA 02111 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"issue":"4","key":"2025021301020386000_ref1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nn.3648","article-title":"A solution to dependency: using multilevel analysis to accommodate nested data","volume":"17","author":"Aarts","year":"2014","journal-title":"Nat Neurosci"},{"issue":"12","key":"2025021301020386000_ref2","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1089\/089771503322686094","article-title":"Moderate controlled cortical contusion in pigs: effects on multi-parametric neuromonitoring and clinical relevance","volume":"20","author":"Alessandri","year":"2003","journal-title":"J Neurotrauma"},{"issue":"1","key":"2025021301020386000_ref3","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1056\/NEJM199801013380104","article-title":"A population-based study of seizures after traumatic brain injuries","volume":"338","author":"Annegers","year":"1998","journal-title":"N Engl J Med"},{"issue":"1","key":"2025021301020386000_ref4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s11940-002-0004-6","article-title":"Cognitive impairment following traumatic brain injury","volume":"4","author":"Arciniegas","year":"2002","journal-title":"Curr Treat Options Neurol"},{"issue":"3","key":"2025021301020386000_ref5","doi-asserted-by":"crossref","DOI":"10.1117\/1.NPh.4.3.035001","article-title":"Targeted ischemic stroke induction and mesoscopic imaging assessment of blood flow and ischemic depolarization in awake mice","volume":"4","author":"Balbi","year":"2017","journal-title":"Neurophotonics"},{"issue":"1","key":"2025021301020386000_ref6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41592-019-0625-2","article-title":"Simultaneous mesoscopic and two-photon imaging of neuronal activity in cortical circuits","volume":"17","author":"Barson","year":"2020","journal-title":"Nat Methods"},{"key":"2025021301020386000_ref7","article-title":"Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior","volume-title":"Nat Neurosci","author":""},{"issue":"5","key":"2025021301020386000_ref8","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1089\/neu.2011.1954","article-title":"Development of post-traumatic epilepsy after controlled cortical impact and lateral fluid-percussion-induced brain injury in the mouse","volume":"29","author":"Bolkvadze","year":"2012","journal-title":"J Neurotrauma"},{"issue":"1","key":"2025021301020386000_ref9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1101\/lm.1650110","article-title":"Object recognition memory and the rodent hippocampus","volume":"17","author":"Broadbent","year":"2010","journal-title":"Learn Mem"},{"issue":"3 Suppl","key":"2025021301020386000_ref10","first-page":"S25","article-title":"Surgical management of traumatic parenchymal lesions","volume":"58","author":"Bullock","year":"2006","journal-title":"Neurosurgery"},{"issue":"3","key":"2025021301020386000_ref11","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.expneurol.2015.03.020","article-title":"Astrocyte roles in traumatic brain injury","volume":"275","author":"Burda","year":"2016","journal-title":"Exp Neurol"},{"issue":"2","key":"2025021301020386000_ref12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.neuron.2013.12.034","article-title":"Reactive gliosis and the multicellular response to cns damage and disease","volume":"81","author":"Burda","year":"2014","journal-title":"Neuron"},{"issue":"8","key":"2025021301020386000_ref13","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1093\/cercor\/bhu041","article-title":"Traumatic brain injury increases cortical glutamate network activity by compromising gabaergic control","volume":"25","author":"Cantu","year":"2015","journal-title":"Cereb Cortex"},{"issue":"3","key":"2025021301020386000_ref14","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.neuroimage.2010.12.046","article-title":"Principles of recovery from traumatic brain injury: reorganization of functional networks","volume":"55","author":"Castellanos","year":"2011","journal-title":"NeuroImage"},{"issue":"Pt 8","key":"2025021301020386000_ref15","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1093\/brain\/awq174","article-title":"Reorganization of functional connectivity as a correlate of cognitive recovery in acquired brain injury","volume":"133","author":"Castellanos","year":"2010","journal-title":"Brain"},{"issue":"7","key":"2025021301020386000_ref16","first-page":"1326","article-title":"Frequencies contributing to functional connectivity in the cerebral cortex in \"resting-state\" data","volume":"22","author":"Cordes","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"2025021301020386000_ref17","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105943","article-title":"Wide-field calcium imaging reveals widespread changes in cortical functional connectivity following mild traumatic brain injury in the mouse","volume":"176","author":"Cramer","year":"2023","journal-title":"Neurobiol Dis"},{"issue":"2","key":"2025021301020386000_ref18","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0165-5728(99)00148-4","article-title":"Il-10 levels in cerebrospinal fluid and serum of patients with severe traumatic brain injury: relationship to il-6, tnf-alpha, tgf-beta1 and blood-brain barrier function","volume":"101","author":"Csuka","year":"1999","journal-title":"J Neuroimmunol"},{"issue":"7","key":"2025021301020386000_ref19","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41592-019-0435-6","article-title":"High-performance calcium sensors for imaging activity in neuronal populations and microcompartments","volume":"16","author":"Dana","year":"2019","journal-title":"Nat Methods"},{"issue":"1","key":"2025021301020386000_ref20","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s40478-021-01165-y","article-title":"In-depth characterization of a mouse model of post-traumatic epilepsy for biomarker and drug discovery","volume":"9","author":"Di Sapia","year":"2021","journal-title":"Acta Neuropathol Commun"},{"issue":"4","key":"2025021301020386000_ref21","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3758\/BRM.41.4.1149","article-title":"Statistical power analyses using g*power 3.1: tests for correlation and regression analyses","volume":"41","author":"Faul","year":"2009","journal-title":"Behav Res Methods"},{"issue":"2","key":"2025021301020386000_ref22","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G*power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"Faul","year":"2007","journal-title":"Behav Res Methods"},{"issue":"9","key":"2025021301020386000_ref23","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1089\/neu.2010.1370","article-title":"Hippocampal theta dysfunction after lateral fluid percussion injury","volume":"27","author":"Fedor","year":"2010","journal-title":"J Neurotrauma"},{"key":"2025021301020386000_ref24","volume-title":"Paxinos and franklin's the mouse brain in stereotaxic coordinates","author":"Franklin","year":"2013"},{"issue":"11","key":"2025021301020386000_ref25","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1136\/jnnp-2017-317557","article-title":"Understanding neurodegeneration after traumatic brain injury: from mechanisms to clinical trials in dementia","volume":"90","author":"Graham","year":"2019","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"2025021301020386000_ref26","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1038\/s41467-018-04920-3","article-title":"Task-induced brain state manipulation improves prediction of individual traits","volume":"9","author":"Greene","year":"2018","journal-title":"Nat Commun"},{"issue":"2","key":"2025021301020386000_ref27","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/ana.21224","article-title":"Mapping functional connectivity in patients with brain lesions","volume":"63","author":"Guggisberg","year":"2008","journal-title":"Ann Neurol"},{"issue":"5","key":"2025021301020386000_ref28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064078","article-title":"Rapamycin attenuates the development of posttraumatic epilepsy in a mouse model of traumatic brain injury","volume":"8","author":"Guo","year":"2013","journal-title":"PLoS One"},{"key":"2025021301020386000_ref29","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.neuroimage.2013.08.017","article-title":"Disrupted modular organization of resting-state cortical functional connectivity in U.S. military personnel following concussive 'mild' blast-related traumatic brain injury","volume":"84","author":"Han","year":"2014","journal-title":"NeuroImage"},{"key":"2025021301020386000_ref30","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.expneurol.2015.12.020","article-title":"Disconnection and hyper-connectivity underlie reorganization after tbi: a rodent functional connectomic analysis","volume":"277","author":"Harris","year":"2016","journal-title":"Exp Neurol"},{"issue":"6","key":"2025021301020386000_ref31","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1523\/JNEUROSCI.4547-13.2014","article-title":"Precise control of movement kinematics by optogenetic inhibition of purkinje cell activity","volume":"34","author":"Heiney","year":"2014","journal-title":"J Neurosci"},{"issue":"15","key":"2025021301020386000_ref32","doi-asserted-by":"crossref","first-page":"6169","DOI":"10.1073\/pnas.1219562110","article-title":"Structural foundations of resting-state and task-based functional connectivity in the human brain","volume":"110","author":"Hermundstad","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"2025021301020386000_ref33","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.expneurol.2008.10.005","article-title":"Posttraumatic epilepsy after controlled cortical impact injury in mice","volume":"215","author":"Hunt","year":"2009","journal-title":"Exp Neurol"},{"issue":"3","key":"2025021301020386000_ref34","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1152\/jn.00957.2009","article-title":"Regionally localized recurrent excitation in the dentate gyrus of a cortical contusion model of posttraumatic epilepsy","volume":"103","author":"Hunt","year":"2010","journal-title":"J Neurophysiol"},{"key":"2025021301020386000_ref35","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.neuroimage.2013.05.079","article-title":"Dynamic functional connectivity: promise, issues, and interpretations","volume":"80","author":"Hutchison","year":"2013","journal-title":"NeuroImage"},{"issue":"47","key":"2025021301020386000_ref36","doi-asserted-by":"crossref","first-page":"18515","DOI":"10.1523\/JNEUROSCI.2126-13.2013","article-title":"A theta-gamma oscillation code for neuronal coordination during motor behavior","volume":"33","author":"Igarashi","year":"2013","journal-title":"J Neurosci"},{"key":"2025021301020386000_ref37","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108213","article-title":"The adenosine a1 receptor agonist wag 994 suppresses acute kainic acid-induced status epilepticus in vivo","volume":"176","author":"Klaft","year":"2020","journal-title":"Neuropharmacology"},{"issue":"11","key":"2025021301020386000_ref38","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.126506","article-title":"Glycolytic inhibitor 2-deoxyglucose prevents cortical hyperexcitability after traumatic brain injury","volume":"5","author":"Koenig","year":"2019","journal-title":"JCI Insight"},{"issue":"1","key":"2025021301020386000_ref39","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12974-017-0819-4","article-title":"Microglial-derived microparticles mediate neuroinflammation after traumatic brain injury","volume":"14","author":"Kumar","year":"2017","journal-title":"J Neuroinflammation"},{"issue":"45","key":"2025021301020386000_ref40","doi-asserted-by":"crossref","first-page":"E4266","DOI":"10.1073\/pnas.1318325110","article-title":"High-throughput imaging of neuronal activity in caenorhabditis elegans","volume":"110","author":"Larsch","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"2025021301020386000_ref41","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1743-0003-11-14","article-title":"Walking reduces sensorimotor network connectivity compared to standing","volume":"11","author":"Lau","year":"2014","journal-title":"J Neuroeng Rehabil"},{"issue":"2","key":"2025021301020386000_ref42","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1089\/neu.2012.2646","article-title":"Medial septal nucleus theta frequency deep brain stimulation improves spatial working memory after traumatic brain injury","volume":"30","author":"Lee","year":"2013","journal-title":"J Neurotrauma"},{"issue":"1","key":"2025021301020386000_ref43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/neu.1988.5.1","article-title":"Controlled cortical impact: a new experimental brain injury model","volume":"5","author":"Lighthall","year":"1988","journal-title":"J Neurotrauma"},{"issue":"2","key":"2025021301020386000_ref44","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1089\/neu.1990.7.65","article-title":"Characterization of axonal injury produced by controlled cortical impact","volume":"7","author":"Lighthall","year":"1990","journal-title":"J Neurotrauma"},{"issue":"4","key":"2025021301020386000_ref45","doi-asserted-by":"crossref","first-page":"041405","DOI":"10.1117\/1.NPh.2.4.041405","article-title":"Network analysis of mesoscale optical recordings to assess regional, functional connectivity","volume":"2","author":"Lim","year":"2015","journal-title":"Neurophotonics"},{"issue":"12","key":"2025021301020386000_ref46","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1038\/s41593-022-01202-6","article-title":"Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity","volume":"25","author":"Lohani","year":"2022","journal-title":"Nat Neurosci"},{"issue":"17","key":"2025021301020386000_ref47","doi-asserted-by":"crossref","first-page":"e2398","DOI":"10.1212\/WNL.0000000000010825","article-title":"The subcortical basis of outcome and cognitive impairment in tbi: a longitudinal cohort study","volume":"95","author":"Lutkenhoff","year":"2020","journal-title":"Neurology"},{"issue":"1705","key":"2025021301020386000_ref48","doi-asserted-by":"crossref","first-page":"20150360","DOI":"10.1098\/rstb.2015.0360","article-title":"Wide-field optical mapping of neural activity and brain haemodynamics: considerations and novel approaches","volume":"371","author":"Ma","year":"2016","journal-title":"Philos Trans R Soc Lond Ser B Biol Sci"},{"issue":"5","key":"2025021301020386000_ref49","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s003810050389","article-title":"Surgery or conservative treatment in children with traumatic intracerebral haematoma","volume":"15","author":"Mandera","year":"1999","journal-title":"Childs Nerv Syst"},{"issue":"1","key":"2025021301020386000_ref50","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1037\/h0076177","article-title":"Relationship between hippocampal theta activity and running speed in the rat","volume":"88","author":"McFarland","year":"1975","journal-title":"J Comp Physiol Psychol"},{"issue":"17","key":"2025021301020386000_ref51","doi-asserted-by":"crossref","first-page":"4450","DOI":"10.1523\/JNEUROSCI.2446-16.2017","article-title":"Electrocorticographic dynamics as a novel biomarker in five models of epileptogenesis","volume":"37","author":"Milikovsky","year":"2017","journal-title":"J Neurosci"},{"issue":"Pt 10","key":"2025021301020386000_ref52","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1093\/brain\/awl165","article-title":"Essential protective roles of reactive astrocytes in traumatic brain injury","volume":"129","author":"Myer","year":"2006","journal-title":"Brain"},{"key":"2025021301020386000_ref53","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2020.600171","article-title":"Recovery of theta frequency oscillations in rats following lateral fluid percussion corresponds with a mild cognitive phenotype","volume":"11","author":"Ondek","year":"2020","journal-title":"Front Neurol"},{"key":"2025021301020386000_ref54","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3389\/fnsys.2018.00064","article-title":"The cortical states of wakefulness","volume":"12","author":"Poulet","year":"2018","journal-title":"Front Syst Neurosci"},{"issue":"11","key":"2025021301020386000_ref56","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1089\/neu.2014.3847","article-title":"Is traumatic brain injury associated with reduced inter-hemispheric functional connectivity? A study of large-scale resting state networks following traumatic brain injury","volume":"33","author":"Rigon","year":"2016","journal-title":"J Neurotrauma"},{"issue":"10","key":"2025021301020386000_ref57","doi-asserted-by":"crossref","first-page":"eadd1101","DOI":"10.1126\/sciadv.add1101","article-title":"Brain injury accelerates the onset of a reversible age-related microglial phenotype associated with inflammatory neurodegeneration","volume":"9","author":"Ritzel","year":"2023","journal-title":"Sci Adv"},{"issue":"1","key":"2025021301020386000_ref58","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/s41467-022-28591-3","article-title":"Increased fmri connectivity upon chemogenetic inhibition of the mouse prefrontal cortex","volume":"13","author":"Rocchi","year":"2022","journal-title":"Nat Commun"},{"issue":"7578","key":"2025021301020386000_ref59","doi-asserted-by":"crossref","first-page":"S193","DOI":"10.1038\/nature16035","article-title":"Global neurotrauma research challenges and opportunities","volume":"527","author":"Rubiano","year":"2015","journal-title":"Nature"},{"key":"2025021301020386000_ref60","doi-asserted-by":"crossref","first-page":"1179069519844020","DOI":"10.1177\/1179069519844020","article-title":"Sex differences in animal models of traumatic brain injury","volume":"13","author":"Rubin","year":"2019","journal-title":"J Exp Neurosci"},{"issue":"10","key":"2025021301020386000_ref61","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1212\/WNL.35.10.1406","article-title":"Epilepsy after penetrating head injury. I. Clinical correlates: a report of the Vietnam head injury study","volume":"35","author":"Salazar","year":"1985","journal-title":"Neurology"},{"issue":"3","key":"2025021301020386000_ref62","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/jcbfm.2009.240","article-title":"Role of chemokines in cns health and pathology: a focus on the ccl2\/ccr2 and cxcl8\/cxcr2 networks","volume":"30","author":"Semple","year":"2010","journal-title":"J Cereb Blood Flow Metab"},{"issue":"10","key":"2025021301020386000_ref63","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1523\/JNEUROSCI.1067-18.2018","article-title":"Repetitive diffuse mild traumatic brain injury causes an atypical astrocyte response and spontaneous recurrent seizures","volume":"39","author":"Shandra","year":"2019","journal-title":"J Neurosci"},{"issue":"2","key":"2025021301020386000_ref64","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/s41593-019-0559-0","article-title":"Breakdown of spatial coding and interneuron synchronization in epileptic mice","volume":"23","author":"Shuman","year":"2020","journal-title":"Nat Neurosci"},{"issue":"1","key":"2025021301020386000_ref65","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.neuron.2005.02.028","article-title":"Prefrontal phase locking to hippocampal theta oscillations","volume":"46","author":"Siapas","year":"2005","journal-title":"Neuron"},{"key":"2025021301020386000_ref66","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jneumeth.2016.04.012","article-title":"Intact skull chronic windows for mesoscopic wide-field imaging in awake mice","volume":"267","author":"Silasi","year":"2016","journal-title":"J Neurosci Methods"},{"issue":"1","key":"2025021301020386000_ref67","doi-asserted-by":"crossref","first-page":"12406","DOI":"10.1038\/s41598-021-91853-5","article-title":"Detecting functional connectivity disruptions in a translational pediatric traumatic brain injury porcine model using resting-state and task-based fmri","volume":"11","author":"Simchick","year":"2021","journal-title":"Sci Rep"},{"issue":"5","key":"2025021301020386000_ref68","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/nn.3690","article-title":"Contributions and challenges for network models in cognitive neuroscience","volume":"17","author":"Sporns","year":"2014","journal-title":"Nat Neurosci"},{"issue":"2","key":"2025021301020386000_ref69","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s11682-012-9157-4","article-title":"Multiple resting state network functional connectivity abnormalities in mild traumatic brain injury","volume":"6","author":"Stevens","year":"2012","journal-title":"Brain Imaging Behav"},{"key":"2025021301020386000_ref70","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.neuroscience.2019.12.006","article-title":"Aquaporin-4 dysregulation in a controlled cortical impact injury model of posttraumatic epilepsy","volume":"428","author":"Szu","year":"2020","journal-title":"Neuroscience"},{"issue":"Suppl 2","key":"2025021301020386000_ref71","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1528-1167.2008.02005.x","article-title":"Preventing and treating posttraumatic seizures: the human experience","volume":"50","author":"Temkin","year":"2009","journal-title":"Epilepsia"},{"key":"2025021301020386000_ref72","article-title":"Report to Congress: Traumatic Brain Injury in the United States","volume-title":"Centers for Disease Control and Prevention","author":""},{"issue":"31","key":"2025021301020386000_ref73","doi-asserted-by":"crossref","first-page":"7513","DOI":"10.1523\/JNEUROSCI.3560-16.2017","article-title":"Mesoscale mapping of mouse cortex reveals frequency-dependent cycling between distinct macroscale functional modules","volume":"37","author":"Vanni","year":"2017","journal-title":"J Neurosci"},{"issue":"5","key":"2025021301020386000_ref74","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1089\/neu.2018.5769","article-title":"Cortical neuromodulation of remote regions after experimental traumatic brain injury normalizes forelimb function but is temporally dependent","volume":"36","author":"Verley","year":"2019","journal-title":"J Neurotrauma"},{"issue":"3","key":"2025021301020386000_ref75","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.neuron.2015.03.028","article-title":"Arousal and locomotion make distinct contributions to cortical activity patterns and visual encoding","volume":"86","author":"Vinck","year":"2015","journal-title":"Neuron"},{"issue":"2","key":"2025021301020386000_ref76","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze: procedures for assessing spatial and related forms of learning and memory","volume":"1","author":"Vorhees","year":"2006","journal-title":"Nat Protoc"},{"issue":"7","key":"2025021301020386000_ref77","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1682\/JRRD.2006.12.0158","article-title":"Motor impairment after severe traumatic brain injury: a longitudinal multicenter study","volume":"44","author":"Walker","year":"2007","journal-title":"J Rehabil Res Dev"},{"issue":"13","key":"2025021301020386000_ref78","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1089\/neu.2012.2456","article-title":"The effect of injury severity on behavior: a phenotypic study of cognitive and emotional deficits after mild, moderate, and severe controlled cortical impact injury in mice","volume":"29","author":"Washington","year":"2012","journal-title":"J Neurotrauma"},{"issue":"6","key":"2025021301020386000_ref79","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1152\/jn.01056.2015","article-title":"Large-scale imaging of cortical dynamics during sensory perception and behavior","volume":"115","author":"Wekselblatt","year":"2016","journal-title":"J Neurophysiol"},{"issue":"12","key":"2025021301020386000_ref80","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.1093\/cercor\/bhab373","article-title":"Wide-field calcium imaging of dynamic cortical networks during locomotion","volume":"32","author":"West","year":"2022","journal-title":"Cereb Cortex"},{"issue":"7","key":"2025021301020386000_ref81","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1523\/JNEUROSCI.2469-20.2020","article-title":"Traumatic brain injury causes chronic cortical inflammation and neuronal dysfunction mediated by microglia","volume":"41","author":"Witcher","year":"2021","journal-title":"J Neurosci"},{"issue":"1","key":"2025021301020386000_ref82","doi-asserted-by":"crossref","first-page":"5992","DOI":"10.1038\/s41467-021-26255-2","article-title":"Mesonet\u00a0allows automated scaling and segmentation of mouse mesoscale cortical maps using machine learning","volume":"12","author":"Xiao","year":"2021","journal-title":"Nat Commun"},{"issue":"2","key":"2025021301020386000_ref83","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/nrn3407","article-title":"Animal models of traumatic brain injury","volume":"14","author":"Xiong","year":"2013","journal-title":"Nat Rev Neurosci"},{"issue":"4","key":"2025021301020386000_ref84","doi-asserted-by":"crossref","first-page":"fcab244","DOI":"10.1093\/braincomms\/fcab244","article-title":"Compensatory functional connectome changes in a rat model of traumatic brain injury","volume":"3","author":"Yang","year":"2021","journal-title":"Brain Commun"},{"issue":"7954","key":"2025021301020386000_ref85","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/s41586-023-05828-9","article-title":"Fast and sensitive gcamp calcium indicators for imaging neural populations","volume":"615","author":"Zhang","year":"2023","journal-title":"Nature"},{"issue":"15","key":"2025021301020386000_ref86","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1089\/neu.2012.2511","article-title":"Comparing the predictive value of multiple cognitive, affective, and motor tasks after rodent traumatic brain injury","volume":"29","author":"Zhao","year":"2012","journal-title":"J Neurotrauma"}],"container-title":["Cerebral Cortex"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cercor\/article-pdf\/34\/2\/bhae038\/59836015\/bhae038.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cercor\/article-pdf\/34\/2\/bhae038\/59836015\/bhae038.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T20:02:29Z","timestamp":1739390549000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cercor\/article\/doi\/10.1093\/cercor\/bhae038\/7607167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,31]]},"references-count":85,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,1,31]]}},"URL":"https:\/\/doi.org\/10.1093\/cercor\/bhae038","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.10.06.560776","asserted-by":"object"}]},"ISSN":["1047-3211","1460-2199"],"issn-type":[{"value":"1047-3211","type":"print"},{"value":"1460-2199","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,2]]},"published":{"date-parts":[[2024,1,31]]},"article-number":"bhae038"}}