{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T11:47:09Z","timestamp":1773056829824,"version":"3.50.1"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Previous studies have suggested a correlation between hearing loss (HL) and cortical alterations, but the specific brain regions that may be affected are unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Genome-wide association study (GWAS) data for 3 subtypes of HL phenotypes, sensorineural hearing loss (SNHL), conductive hearing loss, and mixed hearing loss, were selected as exposures, and GWAS data for brain structure-related traits were selected as outcomes. The inverse variance weighted method was used as the main estimation method.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Negative associations were identified between genetically predicted SNHL and brain morphometric indicators (cortical surface area, cortical thickness, or volume of subcortical structures) in specific brain regions, including the bankssts (\u03b2\u2009=\u2009\u22120.006\u00a0mm, P\u2009=\u20090.016), entorhinal cortex (\u03b2\u2009=\u2009\u22124.856\u00a0mm2, P\u2009=\u20090.029), and hippocampus (\u03b2\u2009=\u2009\u221224.819\u00a0cm3, P\u2009=\u20090.045), as well as in brain regions functionally associated with visual perception, including the pericalcarine (\u03b2\u2009=\u2009\u221210.009\u00a0cm3, P\u2009=\u20090.013).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Adaptive changes and functional remodeling of brain structures occur in patients with genetically predicted HL. Brain regions functionally associated with auditory perception, visual perception, and memory function are the main brain regions vulnerable in HL.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cercor\/bhae084","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T05:48:47Z","timestamp":1710740927000},"source":"Crossref","is-referenced-by-count":3,"title":["Associations of hearing loss and structural changes in specific cortical regions: a Mendelian randomization study"],"prefix":"10.1093","volume":"34","author":[{"given":"Xiaoduo","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurology & Innovation Center for Neurological Disorders , Xuanwu Hospital, , 45 Changchun Street, Xicheng District, Beijing, 100053 , China"},{"name":"Capital Medical University, National Center for Neurological Disorders , Xuanwu Hospital, , 45 Changchun Street, Xicheng District, Beijing, 100053 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lubo","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology , Beijing Friendship Hospital, , National Clinical Research Center for Digestive Diseases, Beijing Digestive Disease Center, 95 Yong'an Road, Xicheng District, Beijing, 100050 , China"},{"name":"Capital Medical University , Beijing Friendship Hospital, , National Clinical Research Center for Digestive Diseases, Beijing Digestive Disease Center, 95 Yong'an Road, Xicheng District, Beijing, 100050 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enze","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology , Beijing Anzhen Hospital, , 2 Anzhen Road, Chaoyang District, Beijing, 100029 , China"},{"name":"Capital Medical University, National Clinical Research Center for Cardiovascular Diseases , Beijing Anzhen Hospital, , 2 Anzhen Road, Chaoyang District, Beijing, 100029 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Cardiology , Beijing Anzhen Hospital, , 2 Anzhen Road, Chaoyang District, Beijing, 100029 , China"},{"name":"Capital Medical University, National Clinical Research Center for Cardiovascular Diseases , Beijing Anzhen Hospital, , 2 Anzhen Road, Chaoyang District, Beijing, 100029 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,3,17]]},"reference":[{"issue":"4","key":"2024031805484177100_ref1","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1192\/bjp.bp.114.153536","article-title":"Lifetime hypertension as a predictor of brain structure in older adults: cohort study with a 28-year follow-up","volume":"206","author":"Allan","year":"2015","journal-title":"Brit J Psychiatry J Mental 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