{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:47:15Z","timestamp":1753876035216,"version":"3.41.2"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82120108014","82071908"],"award-info":[{"award-number":["82120108014","82071908"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","award":["2021-I2M-C&T-A-022"],"award-info":[{"award-number":["2021-I2M-C&T-A-022"]}]},{"name":"Chengdu Science and Technology Office, Major Technology Application Demonstration Project","award":["2022-YF09-00062-SN","2022-GH03-00017-HZ"],"award-info":[{"award-number":["2022-YF09-00062-SN","2022-GH03-00017-HZ"]}]},{"name":"1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University","award":["ZYGD23003"],"award-info":[{"award-number":["ZYGD23003"]}]},{"name":"Sichuan Science and Technology Program","award":["2021JDTD0002"],"award-info":[{"award-number":["2021JDTD0002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Schizophrenia has been considered to exhibit sex-related clinical differences that might be associated with distinctly abnormal brain asymmetries between sexes. One hundred and thirty-two antipsychotic-na\u00efve first-episode patients with schizophrenia and 150 healthy participants were recruited in this study to investigate whether cortical asymmetry would exhibit sex-related abnormalities in schizophrenia. After a 1-yr follow-up, patients were rescanned to obtain the effect of antipsychotic treatment on cortical asymmetry. Male patients were found to show increased lateralization index while female patients were found to exhibit decreased lateralization index in widespread regions when compared with healthy participants of the corresponding sex. Specifically, the cortical asymmetry of male and female patients showed contrary trends in the cingulate, orbitofrontal, parietal, temporal, occipital, and insular cortices. This result suggested male patients showed a leftward shift of asymmetry while female patients showed a rightward shift of asymmetry in these above regions that related to language, vision, emotion, and cognition. Notably, abnormal lateralization indices remained stable after antipsychotic treatment. The contrary trends in asymmetry between female and male patients with schizophrenia together with the persistent abnormalities after antipsychotic treatment suggested the altered brain asymmetries in schizophrenia might be sex-related disturbances, intrinsic, and resistant to the effect of antipsychotic therapy.<\/jats:p>","DOI":"10.1093\/cercor\/bhae173","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T03:47:47Z","timestamp":1714967267000},"source":"Crossref","is-referenced-by-count":1,"title":["Sex-related cortical asymmetry in antipsychotic-na\u00efve first-episode schizophrenia"],"prefix":"10.1093","volume":"34","author":[{"given":"Xiyue","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Radiology and Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University , No. 37 Guoxue Xiang, Wuhou District, Chengdu, Sichuan Province 610041 , China"},{"name":"Huaxi MR Research Center, West China Hospital of Sichuan University , No. 37 Guoxue Xiang, Wuhou District, Chengdu, Sichuan Province 610041 , China"},{"name":"Research Unit of Psychoradiology, Chinese Academy of Medical Sciences , No. 37 Guoxue Xiang, Wuhou District, Chengdu, Sichuan Province 610041 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naici","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology and Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University , No. 37 Guoxue Xiang, Wuhou District, Chengdu, Sichuan Province 610041 , China"},{"name":"Huaxi MR Research Center, West China Hospital of Sichuan University , No. 37 Guoxue Xiang, Wuhou District, Chengdu, Sichuan Province 610041 , China"},{"name":"Research Unit of Psychoradiology, Chinese Academy of Medical Sciences , No. 37 Guoxue Xiang, Wuhou District, Chengdu, Sichuan Province 610041 , 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Sichuan Province 610041 , China"},{"name":"Huaxi MR Research Center, West China Hospital of Sichuan University , No. 37 Guoxue Xiang, Wuhou District, Chengdu, Sichuan Province 610041 , China"},{"name":"Research Unit of Psychoradiology, Chinese Academy of Medical Sciences , No. 37 Guoxue Xiang, Wuhou District, Chengdu, Sichuan Province 610041 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology and Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University , No. 37 Guoxue Xiang, Wuhou District, Chengdu, Sichuan Province 610041 , China"},{"name":"Huaxi MR Research Center, West China Hospital of Sichuan University , No. 37 Guoxue Xiang, Wuhou District, Chengdu, Sichuan Province 610041 , China"},{"name":"Research Unit of Psychoradiology, Chinese Academy of Medical Sciences , No. 37 Guoxue Xiang, Wuhou District, Chengdu, Sichuan Province 610041 , China"},{"name":"Department of Radiology, The Third Hospital of Mianyang\/Sichuan Mental Health Center , No. 190 Jiannan Road East, Youxian District, Mianyang, Sichuan Province 621000 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiyong","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Radiology and Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University , No. 37 Guoxue Xiang, Wuhou District, Chengdu, Sichuan Province 610041 , China"},{"name":"Huaxi MR Research Center, West China Hospital of Sichuan University , No. 37 Guoxue Xiang, Wuhou District, Chengdu, Sichuan Province 610041 , China"},{"name":"Research Unit of Psychoradiology, Chinese Academy of Medical Sciences , No. 37 Guoxue Xiang, Wuhou District, Chengdu, Sichuan Province 610041 , China"},{"name":"Department of Radiology, West China Xiamen Hospital of Sichuan University , 699 Jinyuan Xi 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