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This study aimed to investigate the relationship between metabolite levels, cognitive function, and node characteristics in presbycusis based on graph theory methods. Eighty-four elderly individuals with presbycusis and 63 age-matched normal hearing controls underwent magnetic resonance spectroscopy, functional magnetic resonance imaging scans, audiological assessment, and cognitive assessment. Compared with the normal hearing group, presbycusis patients exhibited reduced gamma-aminobutyric acid and glutamate levels in the auditory region, increased nodal characteristics in the temporal lobe and precuneus, as well as decreased nodal characteristics in the superior occipital gyrus and medial orbital. The right gamma-aminobutyric acid levels were negatively correlated with the degree centrality in the right precuneus and the executive function. Degree centrality in the right precuneus exhibited significant correlations with information processing speed and executive function, while degree centrality in the left medial orbital demonstrated a negative association with speech recognition ability. The degree centrality and node efficiency in the superior occipital gyrus exhibited a negative association with hearing loss and speech recognition ability, respectively. These observed changes indicate alterations in metabolite levels and reorganization patterns at the brain network level after auditory deprivation.<\/jats:p>","DOI":"10.1093\/cercor\/bhae181","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T05:17:12Z","timestamp":1715145432000},"source":"Crossref","is-referenced-by-count":2,"title":["Aberrant auditory metabolite levels and topological properties are associated with cognitive decline in presbycusis patients"],"prefix":"10.1093","volume":"34","author":[{"given":"Yao","family":"Wang","sequence":"first","affiliation":[{"name":"School of Life Sciences, Tiangong University , Binshui West Road No. 399, Tianjin 300387 , China"},{"name":"Tianjin Key Laboratory of Optoelectronic Detection Technology and System , Binshui West Road No. 399, Tianjin 300387 , China"},{"name":"School of Precision Instruments and Optoelectronics Engineering, Tianjin University , Weijin Road No. 92, Tianjin 300072 , 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