{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:18:04Z","timestamp":1790309884194,"version":"4.1.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171864"],"award-info":[{"award-number":["82171864"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871519"],"award-info":[{"award-number":["81871519"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bureau of Science and Technology of Hangzhou","award":["20201203B182"],"award-info":[{"award-number":["20201203B182"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The effects of hypoxia on brain function remain largely unknown. This study aimed to clarify this issue by visual-stimulated functional magnetic resonance imaging design. Twenty-three college students with a 30-d high-altitude exposure were tested before, 1\u00a0week and 3\u00a0months after returning to sea level. Brain functional magnetic resonance imaging and retinal electroretinogram were acquired. One week after returning to sea level, decreased blood oxygenation level dependent in the right lingual gyrus accompanied with increased blood oxygenation level dependent in the frontal cortex and insular cortex, and decreased amplitude of electroretinogram a-wave in right eye; moreover, the bilateral lingual gyri showed increased functional connectivity within the dorsal visual stream pathway, and the blood oxygenation level dependent signals in the right lingual gyrus showed positive correlation with right retinal electroretinogram a-wave. Three months after returning to sea level, the blood oxygenation level dependent signals recovered to normal level, while intensively increased blood oxygenation level dependent signals in a broad of brain regions and decreased retinal electroretinogram were also existed. In conclusion, hypoxic exposure has long-term effects on visual cortex, and the impaired retinal electroretinogram may contribute to it. The increased functional connectivity of dorsal stream may compensate for the decreased function of retinal photoreceptor cells to maintain normal visual function.<\/jats:p>","DOI":"10.1093\/cercor\/bhae198","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T15:45:54Z","timestamp":1714146354000},"source":"Crossref","is-referenced-by-count":10,"title":["Neuroplasticity of visual brain network induced by hypoxia"],"prefix":"10.1093","volume":"34","author":[{"given":"Xinjuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute of Brain Diseases and Cognition , School of Medicine, , 4221 Xiang'an South Road, Xiamen 361102 , China"},{"name":"Xiamen University , School of Medicine, , 4221 Xiang'an South Road, Xiamen 361102 , China"},{"name":"School of Education and Psychology, Minnan Normal University , 36 Xianqianzhi Street, Zhangzhou 363000 , 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Medicine, , 4221 Xiang'an South Road, Xiamen 361102 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Brain Diseases and Cognition , School of Medicine, , 4221 Xiang'an South Road, Xiamen 361102 , China"},{"name":"Xiamen University , School of Medicine, , 4221 Xiang'an South Road, Xiamen 361102 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Radiology, Zhongshan Hospital of Xiamen University, School of Medicine, 201-209 Hubin South Road, Xiamen University , Xiamen 361004 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Hospital of Hangzhou Normal University , 126 Wenzhou Road, Hangzhou 310015 , 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