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Additionally, the neural mechanisms underlying how pain experience modulates individuals\u2019 responses to others\u2019 pain remain unclear. In this study, we explored the effects of pain experience on individuals\u2019 responses to others\u2019 pain and the underlying neural mechanisms. By comparing locomotion, social, exploration, stereotyped, and anxiety-like behaviors of mice without any pain experience (na\u00efve observers) and mice with a similar pain experience (experienced observers) when they observed the pain-free demonstrator with intraperitoneal injection of normal saline and the painful demonstrator with intraperitoneal injection of acetic acid, we found that pain experience of the observers led to decreased social avoidance to the painful demonstrator. Through whole-brain c-Fos quantification, we discovered that pain experience altered neuronal activity and enhanced functional connectivity in the mouse brain. The analysis of complex network and graph theory exhibited that functional connectivity networks and activated hub regions were altered by pain experience. Together, these findings reveal that neuronal activity and functional connectivity networks are involved in the modulation of individuals\u2019 responses to others\u2019 pain by pain experience.<\/jats:p>","DOI":"10.1093\/cercor\/bhae207","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T04:24:11Z","timestamp":1716783851000},"source":"Crossref","is-referenced-by-count":2,"title":["Pain experience reduces social avoidance to others in pain: a c-Fos-based functional connectivity network study in mice"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0277-6041","authenticated-orcid":false,"given":"Jiali","family":"Li","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Brain Function and Disease , Neuroscience Program, , 74 Zhongshan Second Road, Yuexiu District, 510080 Guangzhou , China"},{"name":"Zhongshan School of Medicine and the Fifth Affiliated Hospital, Sun Yat-sen University , Neuroscience Program, , 74 Zhongshan Second Road, Yuexiu District, 510080 Guangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"Qin","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Brain Function and Disease , Neuroscience Program, , 74 Zhongshan Second Road, Yuexiu District, 510080 Guangzhou , China"},{"name":"Zhongshan School of Medicine and the Fifth Affiliated Hospital, Sun Yat-sen University , Neuroscience Program, , 74 Zhongshan Second Road, Yuexiu District, 510080 Guangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zifeng","family":"Zhong","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Brain Function and Disease , Neuroscience Program, , 74 Zhongshan Second Road, Yuexiu District, 510080 Guangzhou , China"},{"name":"Zhongshan School of Medicine and the Fifth Affiliated Hospital, Sun Yat-sen University , Neuroscience Program, , 74 Zhongshan Second Road, Yuexiu District, 510080 Guangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linjie","family":"Meng","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Brain Function and Disease , Neuroscience Program, , 74 Zhongshan Second Road, Yuexiu District, 510080 Guangzhou , China"},{"name":"Zhongshan School of Medicine and the Fifth Affiliated Hospital, Sun Yat-sen University , Neuroscience Program, , 74 Zhongshan Second Road, Yuexiu District, 510080 Guangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianyan","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Brain Function and Disease , Neuroscience Program, , 74 Zhongshan Second Road, Yuexiu District, 510080 Guangzhou , China"},{"name":"Zhongshan School of Medicine and the Fifth Affiliated Hospital, Sun Yat-sen University , Neuroscience Program, , 74 Zhongshan Second 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