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However, establishing which predictors are most strongly associated with post-traumatic stress disorder symptoms is complicated because few studies are able to consider multiple factors simultaneously across the biopsychosocial domains that are implicated by existing theoretical models. Further, post-traumatic stress disorder is heterogeneous, and studies using case-control designs may obscure which factors relate uniquely to symptom dimensions. Here we used Bayesian variable selection to identify the most important predictors for overall post-traumatic stress disorder symptoms and individual symptom dimensions in a community sample of 569 adults (18 to 85\u00a0yr of age). Candidate predictors were selected from previously established risk factors relevant for post-traumatic stress disorder and included psychological measures, behavioral measures, and resting state functional connectivity among brain regions. In a follow-up analysis, we compared results controlling for current depression symptoms in order to examine specificity. Poor sleep quality and dimensions of temperament and impulsivity were consistently associated with greater post-traumatic stress disorder symptom severity. In addition to self-report measures, brain functional connectivity among regions commonly ascribed to the default mode network, central executive network, and salience network explained the unique variability of post-traumatic stress disorder symptoms. This study demonstrates the unique contributions of psychological measures and neural substrates to post-traumatic stress disorder symptoms.<\/jats:p>","DOI":"10.1093\/cercor\/bhae214","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T13:57:05Z","timestamp":1717077425000},"source":"Crossref","is-referenced-by-count":4,"title":["Neural and psychological correlates of post-traumatic stress symptoms in a community adult sample"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7461-0803","authenticated-orcid":false,"given":"Sierra A","family":"Bainter","sequence":"first","affiliation":[{"name":"Department of Psychology, University of Miami , 5665 Ponce de Leon Blvd, Coral Gables, FL 33146 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0126-4425","authenticated-orcid":false,"given":"Zachary T","family":"Goodman","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Miami , 5665 Ponce de Leon Blvd, Coral Gables, FL 33146 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren B","family":"Kupis","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles , 760 Westwood Plaza, Los Angeles, CA 90095 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiara R","family":"Timpano","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Miami , 5665 Ponce de Leon Blvd, Coral Gables, FL 33146 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucina Q","family":"Uddin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles , 760 Westwood Plaza, Los Angeles, CA 90095 ,","place":["United States"]},{"name":"Department of Psychology, University of California Los Angeles , 1285 Psychology Building, Box 951563, Los Angeles, CA 90095-1563 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,30]]},"reference":[{"key":"2025102002020302700_ref1","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.jad.2016.10.037","article-title":"A network approach to the comorbidity between posttraumatic stress disorder and major depressive disorder: the role of overlapping symptoms","volume":"208","author":"Afzali","year":"2017","journal-title":"J Affect Disord"},{"issue":"11","key":"2025102002020302700_ref2","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s11920-017-0840-4","article-title":"A network-based neurobiological model of PTSD: evidence from structural and functional neuroimaging 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