{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T05:12:52Z","timestamp":1786597972952,"version":"build-2736575974"},"reference-count":93,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100005627","name":"Thrasher Research Fund","doi-asserted-by":"publisher","award":["63418"],"award-info":[{"award-number":["63418"]}],"id":[{"id":"10.13039\/100005627","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005627","name":"Thrasher Research Fund","doi-asserted-by":"publisher","award":["72126"],"award-info":[{"award-number":["72126"]}],"id":[{"id":"10.13039\/100005627","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024250","name":"Israel Innovation Authority","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024250","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Faculty of Medical & Health Sciences"},{"DOI":"10.13039\/501100004375","name":"Tel Aviv University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004375","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Placental-related fetal growth restriction, resulting from placental dysfunction, impacts 3\u20135% of pregnancies and is linked to elevated risk of adverse neurodevelopmental outcomes. In response, the fetus employs a mechanism known as brain-sparing, redirecting blood flow to the cerebral circuit, for adequate supply to the brain. In this study we aimed to quantitatively evaluate disparities in gyrification and brain volumes among fetal growth restriction, small for gestational age and appropriate-for gestational-age fetuses. Additionally, we compared fetal growth restriction fetuses with and without brain-sparing. The study encompassed 106 fetuses: 35 fetal growth restriction (14 with and 21 without brain-sparing), 8 small for gestational age, and 63 appropriate for gestational age. Gyrification, supratentorial, and infratentorial brain volumes were automatically computed from T2-weighted magnetic resonance images, following semi-automatic brain segmentation. Fetal growth restriction fetuses exhibited significantly reduced gyrification and brain volumes compared to appropriate for gestational age (P\u2009&amp;lt;\u20090.001). Small for gestational age fetuses displayed significantly reduced gyrification (P\u2009=\u20090.038) and smaller supratentorial volume (P\u2009&amp;lt;\u20090.001) compared to appropriate for gestational age. Moreover, fetal growth restriction fetuses with BS demonstrated reduced gyrification compared to those without BS (P\u2009=\u20090.04), with no significant differences observed in brain volumes. These findings demonstrate that brain development is affected in fetuses with fetal growth restriction, more severely than in small for gestational age, and support the concept that vasodilatation of the fetal middle cerebral artery reflects more severe hypoxemia, affecting brain development.<\/jats:p>","DOI":"10.1093\/cercor\/bhae250","type":"journal-article","created":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T04:35:37Z","timestamp":1718512537000},"source":"Crossref","is-referenced-by-count":15,"title":["Reduced gyrification in fetal growth restriction with prenatal magnetic resonance images"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5506-1498","authenticated-orcid":false,"given":"Bossmat","family":"Yehuda","sequence":"first","affiliation":[{"name":"Sagol Brain Institute, Tel-Aviv Sourasky Medical Center , Tel-Aviv 64239 , Israel"},{"name":"Sagol School of Neuroscience, Tel-Aviv University , Tel-Aviv 69978 , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviad","family":"Rabinowich","sequence":"additional","affiliation":[{"name":"Sagol Brain Institute, Tel-Aviv Sourasky Medical Center , Tel-Aviv 64239 , Israel"},{"name":"Department of Radiology, Tel-Aviv Sourasky Medical Center , Tel-Aviv 64239 , Israel"},{"name":"Faculty of Medical & Health Sciences, Tel-Aviv University , Tel-Aviv 69978 , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayala","family":"Zilberman","sequence":"additional","affiliation":[{"name":"Faculty of Medical & Health Sciences, Tel-Aviv University , Tel-Aviv 69978 , Israel"},{"name":"Department of Obstetrics and Gynecology, Lis Maternity and Women\u2019s Hospital, Tel-Aviv Sourasky Medical Center , Tel-Aviv 64239 , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yair","family":"Wexler","sequence":"additional","affiliation":[{"name":"School of Neurobiology , Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, , Tel-Aviv 69978 , Israel"},{"name":"Tel-Aviv University , Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, , Tel-Aviv 69978 , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina Krajden","family":"Haratz","sequence":"additional","affiliation":[{"name":"Faculty of Medical & Health Sciences, Tel-Aviv University , Tel-Aviv 69978 , Israel"},{"name":"Division of Ultrasound in Obstetrics and Gynecology, Lis Maternity and Women\u2019s Hospital, Tel Aviv Medical Center , Tel Aviv 64239 \u00a0 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elka","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, The Hospital of Sick Children, University of Toronto, Canada. Affiliate to CHEO, University of Ottawa , Ontario K1H 8M5 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liat Ben","family":"Sira","sequence":"additional","affiliation":[{"name":"Sagol School of Neuroscience, Tel-Aviv University , Tel-Aviv 69978 , Israel"},{"name":"Department of Radiology, Tel-Aviv Sourasky Medical Center , Tel-Aviv 64239 , Israel"},{"name":"Faculty of Medical & Health Sciences, Tel-Aviv University , Tel-Aviv 69978 , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liran","family":"Hiersch","sequence":"additional","affiliation":[{"name":"Faculty of Medical & Health Sciences, Tel-Aviv University , Tel-Aviv 69978 , Israel"},{"name":"Department of Obstetrics and Gynecology, Lis Maternity and Women\u2019s Hospital, Tel-Aviv Sourasky Medical Center , Tel-Aviv 64239 , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dafna Ben","family":"Bashat","sequence":"additional","affiliation":[{"name":"Sagol Brain 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