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Using ultra\u2013high field diffusion magnetic resonance imaging, we examined whether microstructural properties (neurite density index and orientation dispersion index) in the locus coeruleus were related to those in cortical and subcortical regions, and whether this was modulated by plasma glial fibrillary acidic protein levels, as a proxy of astrocyte reactivity. In our cohort of 60 healthy individuals (30 to 85\u00a0yr, 50% female), higher glial fibrillary acidic protein correlated with lower neurite density index in frontal cortical regions, the hippocampus, and the amygdala. Furthermore, under higher levels of glial fibrillary acidic protein (above ~\u2009150\u00a0pg\/mL for cortical and\u2009~\u2009145\u00a0pg\/mL for subcortical regions), lower locus coeruleus orientation dispersion index was associated with lower orientation dispersion index in frontotemporal cortical regions and in subcortical regions. Interestingly, individuals with higher locus coeruleus orientation dispersion index exhibited higher orientation dispersion index in these (sub)cortical regions, despite having higher glial fibrillary acidic protein levels. Together, these results suggest that the interaction between locus coeruleus\u2013norepinephrine cells and astrocytes can signal a detrimental or neuroprotective pathway for brain integrity and support the importance of maintaining locus coeruleus neuronal health in aging and in the prevention of age-related neurodegenerative diseases.<\/jats:p>","DOI":"10.1093\/cercor\/bhae261","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T15:16:09Z","timestamp":1717600569000},"source":"Crossref","is-referenced-by-count":8,"title":["Microstructural associations between locus coeruleus, cortical, and subcortical regions are modulated by astrocyte reactivity: a 7T MRI adult lifespan study"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5523-1741","authenticated-orcid":false,"given":"Elise","family":"Beckers","sequence":"first","affiliation":[{"name":"Faculty of Health , Medicine and Life Sciences, , 6229 ET Maastricht , The Netherlands"},{"name":"Mental Health and Neuroscience Research Institute, Alzheimer Centre Limburg, Maastricht University , Medicine and Life Sciences, , 6229 ET Maastricht , The Netherlands"},{"name":"GIGA-CRC Human Imaging, University of Li\u00e8ge , 4000 Li\u00e8ge , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Van Egroo","sequence":"additional","affiliation":[{"name":"Faculty of Health , Medicine and Life Sciences, , 6229 ET Maastricht , The Netherlands"},{"name":"Mental Health and Neuroscience Research Institute, Alzheimer Centre Limburg, Maastricht University , Medicine and Life Sciences, , 6229 ET Maastricht , The Netherlands"},{"name":"Athinoula A. Martinos Center for Biomedical Imaging , Department of Radiology, , Boston, MA 02129 , USA"},{"name":"Massachusetts General Hospital , Department of Radiology, , Boston, MA 02129 , USA"},{"name":"Harvard Medical School , Boston, MA 02115 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J","family":"Ashton","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, Gothenburg , 431 41 M\u00f6lndal , Sweden"},{"name":"King\u2019s College London , Institute of Psychiatry, Psychology and Neuroscience, , London SE5 9RT , UK"},{"name":"Maurice Wohl Institute Clinical Neuroscience Institute , Institute of Psychiatry, Psychology and Neuroscience, , London SE5 9RT , UK"},{"name":"NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation , London SE5 8AF , UK"},{"name":"Centre for Age-Related Medicine, Stavanger University Hospital , 4011 Stavanger , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, Gothenburg , 431 41 M\u00f6lndal , Sweden"},{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital , 431 80 M\u00f6lndal , Sweden"},{"name":"Paris Brain Institute , ICM, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, , 75013 Paris , France"},{"name":"Sorbonne University , ICM, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, , 75013 Paris , France"},{"name":"Neurodegenerative Disorder Research Center , Division of Life Sciences and Medicine, and Department of Neurology, Institute on Aging and Brain Disorders, , Hefei 230036 , China"},{"name":"University of Science and Technology of China and First Affiliated Hospital of USTC , Division of Life Sciences and Medicine, and Department of Neurology, Institute on Aging and Brain Disorders, , Hefei 230036 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Vandewalle","sequence":"additional","affiliation":[{"name":"GIGA-CRC Human Imaging, University of Li\u00e8ge , 4000 Li\u00e8ge , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, Gothenburg , 431 41 M\u00f6lndal , Sweden"},{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital , 431 80 M\u00f6lndal , Sweden"},{"name":"Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology , London WC1E 6BT , UK"},{"name":"UK Dementia Research Institute at UCL , London W1T 7NF , UK"},{"name":"Hong Kong Center for Neurodegenerative Diseases , Hong Kong , China"},{"name":"Wisconsin Alzheimer\u2019s Disease Research Center , University of Wisconsin School of Medicine and Public Health, , Madison, WI 53792 , USA"},{"name":"University of Wisconsin-Madison , University of Wisconsin School of Medicine and Public Health, , Madison, WI 53792 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt A","family":"Poser","sequence":"additional","affiliation":[{"name":"Department of Cognitive Neuroscience , Faculty of Psychology and Neuroscience, , 6229 ER Maastricht , The Netherlands"},{"name":"Maastricht University , Faculty of Psychology and Neuroscience, , 6229 ER Maastricht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi I L","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Faculty of Health , Medicine and Life Sciences, , 6229 ET Maastricht , The Netherlands"},{"name":"Mental Health and Neuroscience Research Institute, Alzheimer Centre Limburg, Maastricht University , Medicine and Life Sciences, , 6229 ET Maastricht , The Netherlands"},{"name":"Athinoula A. 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