{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:28:08Z","timestamp":1790954888047,"version":"4.1.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100031478","name":"NEXTGENERATIONEU","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100031478","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of University and Research"},{"name":"National Recovery and Resilience Plan"},{"name":"MNESYS","award":["PE0000006"],"award-info":[{"award-number":["PE0000006"]}]},{"name":"A Multiscale Integratedapproach to the Study of the Nervous System in Health and Disease","award":["DN. 1553 11.10.2022"],"award-info":[{"award-number":["DN. 1553 11.10.2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Autonomic symptoms in Parkinson\u2019s disease result from variable involvement of the central and peripheral systems, but many aspects remain unclear. The analysis of functional connectivity has shown promising results in assessing the pathophysiology of Parkinson\u2019s disease. This study aims to investigate the association between autonomic symptoms and cortical functional connectivity in early Parkinson\u2019s disease patients using high-density EEG. 53 early Parkinson\u2019s disease patients (F\/M 18\/35) and 49 controls (F\/M 20\/29) were included. Autonomic symptoms were evaluated using the Scales for Outcomes in Parkinson\u2019s disease\u2013Autonomic Dysfunction score. Data were recorded with a 64-channel EEG system. We analyzed cortical functional connectivity, based on weighted phase-lag index, in \u03b8-\u03b1-\u03b2-low-\u03b3 bands. A network-based statistic was used to perform linear regression between Scales for Outcomes in Parkinson\u2019s disease\u2013Autonomic Dysfunction score and functional connectivity in Parkinson\u2019s disease patients. We observed a positive relation between the Scales for Outcomes in Parkinson\u2019s disease\u2013Autonomic Dysfunction score and \u03b1-functional connectivity (network \u03c4\u2009=\u20092.8, P\u2009=\u20090.038). Regions with higher degrees were insula and limbic lobe. Moreover, we found positive correlations between the mean connectivity of this network and the gastrointestinal, cardiovascular, and thermoregulatory domains of Scales for Outcomes in Parkinson\u2019s disease\u2013Autonomic Dysfunction. Our results revealed abnormal functional connectivity in specific areas in Parkinson\u2019s disease patients with greater autonomic symptoms. Insula and limbic areas play a significant role in the regulation of the autonomic system. Increased functional connectivity in these regions might represent the central compensatory mechanism of peripheral autonomic dysfunction in Parkinson\u2019s disease.<\/jats:p>","DOI":"10.1093\/cercor\/bhae270","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T04:16:57Z","timestamp":1720153017000},"source":"Crossref","is-referenced-by-count":17,"title":["Insular and limbic abnormal functional connectivity in early-stage Parkinson\u2019s disease patients with autonomic dysfunction"],"prefix":"10.1093","volume":"34","author":[{"given":"Matteo","family":"Conti","sequence":"first","affiliation":[{"name":"Neurology Unit , Department of Systems Medicine, , Via Montpellier 1, 00133 Rome ,","place":["Italy"]},{"name":"University of Rome \u201cTor Vergata\u201d , Department of Systems Medicine, , Via Montpellier 1, 00133 Rome 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Rome ,","place":["Italy"]},{"name":"University of Rome \u201cTor Vergata\u201d , Department of Systems Medicine, , Via Montpellier 1, 00133 Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola B","family":"Mercuri","sequence":"additional","affiliation":[{"name":"Neurology Unit , Department of Systems Medicine, , Via Montpellier 1, 00133 Rome ,","place":["Italy"]},{"name":"University of Rome \u201cTor Vergata\u201d , Department of Systems Medicine, , Via Montpellier 1, 00133 Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Di Giuliano","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit , Department of Biomedicine and Prevention, , Via Montpellier 1, 00133 Rome ,","place":["Italy"]},{"name":"University of Rome \u201cTor Vergata\u201d , Department of Biomedicine and Prevention, , Via Montpellier 1, 00133 Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"Cerroni","sequence":"additional","affiliation":[{"name":"Neurology Unit , Department of Systems Medicine, , Via Montpellier 1, 00133 Rome ,","place":["Italy"]},{"name":"University of Rome \u201cTor Vergata\u201d , Department of Systems Medicine, , Via Montpellier 1, 00133 Rome ,","place":["Italy"]},{"name":"UOSD Parkinson Centre, Tor Vergata University Hospital , Viale Oxford 81, 00133 Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Pierantozzi","sequence":"additional","affiliation":[{"name":"Neurology Unit , Department of Systems Medicine, , Via Montpellier 1, 00133 Rome ,","place":["Italy"]},{"name":"University of Rome \u201cTor Vergata\u201d , Department of Systems Medicine, , Via Montpellier 1, 00133 Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Schirinzi","sequence":"additional","affiliation":[{"name":"Neurology Unit , Department of Systems Medicine, , Via Montpellier 1, 00133 Rome ,","place":["Italy"]},{"name":"University of Rome \u201cTor Vergata\u201d , Department of Systems Medicine, , Via Montpellier 1, 00133 Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1806-8922","authenticated-orcid":false,"given":"Alessandro","family":"Stefani","sequence":"additional","affiliation":[{"name":"Neurology Unit , Department of Systems Medicine, , Via Montpellier 1, 00133 Rome ,","place":["Italy"]},{"name":"University of Rome \u201cTor Vergata\u201d , Department of Systems Medicine, , Via Montpellier 1, 00133 Rome ,","place":["Italy"]},{"name":"UOSD Parkinson Centre, Tor Vergata University Hospital , Viale Oxford 81, 00133 Rome 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