{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T11:01:34Z","timestamp":1789815694926,"version":"4.0.1"},"reference-count":125,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Institute of Biomedical Imaging and Bioengineering at the National Institutes of Health","award":["T32EB025766"],"award-info":[{"award-number":["T32EB025766"]}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DGE-2234667"],"award-info":[{"award-number":["DGE-2234667"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Medical Research Council","doi-asserted-by":"publisher","award":["MR\/N026969\/1"],"award-info":[{"award-number":["MR\/N026969\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Nonpainful tactile sensory stimuli are processed in the cortex, subcortex, and brainstem. Recent functional magnetic resonance imaging studies have highlighted the value of whole-brain, systems-level investigation for examining sensory processing. However, whole-brain functional magnetic resonance imaging studies are uncommon, in part due to challenges with signal to noise when studying the brainstem. Furthermore, differentiation of small sensory brainstem structures such as the cuneate and gracile nuclei necessitates high-resolution imaging. To address this gap in systems-level sensory investigation, we employed a whole-brain, multi-echo functional magnetic resonance imaging acquisition at 3T with multi-echo independent component analysis denoising and brainstem-specific modeling to enable detection of activation across the entire sensory system. In healthy participants, we examined patterns of activity in response to nonpainful brushing of the right hand, left hand, and right foot (n\u00a0=\u200910 per location), and found the expected lateralization, with distinct cortical and subcortical responses for upper and lower limb stimulation. At the brainstem level, we differentiated the adjacent cuneate and gracile nuclei, corresponding to hand and foot stimulation respectively. Our findings demonstrate that simultaneous cortical, subcortical, and brainstem mapping at 3T could be a key tool to understand the sensory system in both healthy individuals and clinical cohorts with sensory deficits.<\/jats:p>","DOI":"10.1093\/cercor\/bhae273","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T17:53:45Z","timestamp":1718646825000},"source":"Crossref","is-referenced-by-count":20,"title":["Simultaneous cortical, subcortical, and brainstem mapping of sensory activation"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8938-540X","authenticated-orcid":false,"given":"Neha A","family":"Reddy","sequence":"first","affiliation":[{"name":"Department of Physical Therapy and Human Movement Sciences , Feinberg School of Medicine, , Chicago, IL 60611 , United States"},{"name":"Northwestern University , Feinberg School of Medicine, , Chicago, IL 60611 , United States"},{"name":"Department of Biomedical Engineering , McCormick School of Engineering and Applied Sciences, , Evanston, IL 60208 , United States"},{"name":"Northwestern University , McCormick School of Engineering and Applied Sciences, , Evanston, IL 60208 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca G","family":"Clements","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy and Human Movement Sciences , Feinberg School of Medicine, , Chicago, IL 60611 , United States"},{"name":"Northwestern University , Feinberg School of Medicine, , Chicago, IL 60611 , United States"},{"name":"Department of Biomedical Engineering , McCormick School of Engineering and Applied Sciences, , Evanston, IL 60208 , United States"},{"name":"Northwestern University , McCormick School of Engineering and Applied Sciences, , Evanston, IL 60208 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan C W","family":"Brooks","sequence":"additional","affiliation":[{"name":"School of Psychology, University of East Anglia , Norwich NR4 7TJ , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly G","family":"Bright","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy and Human Movement Sciences , Feinberg School of Medicine, , Chicago, IL 60611 , United States"},{"name":"Northwestern University , Feinberg School of Medicine, , Chicago, IL 60611 , United States"},{"name":"Department of Biomedical Engineering , McCormick School of Engineering and Applied Sciences, , Evanston, IL 60208 , United States"},{"name":"Northwestern University , McCormick School of Engineering and Applied Sciences, , Evanston, IL 60208 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"key":"2024062813252021400_ref1","doi-asserted-by":"crossref","first-page":"118135","DOI":"10.1016\/j.neuroimage.2021.118135","article-title":"A high-resolution interactive atlas of the human brainstem using magnetic resonance imaging","volume":"237","author":"Adil","year":"2021","journal-title":"NeuroImage"},{"key":"2024062813252021400_ref2","unstructured":"Ahmed Z, Bandettini PA, Bottenhorn KL, Caballero-Gaudes C, Dowdle LT, DuPre E, Gonzalez-Castillo J, Handwerker D, Heunis S, Kundu P, et\u00a0al. 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