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The inverse-variance weighted method, along with Cochran\u2019s Q test, Mendelian randomization-Egger regression, Mendelian randomization-PRESSO global test, and the leave-one-out approach, were applied to infer causality and assess heterogeneity and pleiotropy. Findings indicate hypertensive disorders of pregnancy are associated with structural brain alterations, including reduced cortical thickness in areas like the insula, isthmus cingulate gyrus, superior temporal gyrus, temporal pole, and transverse temporal gyrus, and an increased surface area in the superior frontal gyrus. Specific associations were found for hypertensive disorders of pregnancy subtypes: chronic hypertension with superimposed preeclampsia increased cortical thickness in the supramarginal gyrus; preeclampsia\/eclampsia led to thinner cortex in the lingual gyrus and larger hippocampal volume and superior parietal lobule surface area. Chronic hypertension was associated with reduced cortical thickness in the caudal and rostral anterior cingulate and increased surface area of the cuneus and thickness of the pars orbitalis cortex. Gestational hypertension showed no significant brain region changes. These insights clarify hypertensive disorders of pregnancies\u2019 neurological and cognitive effects by identifying affected brain regions.<\/jats:p>","DOI":"10.1093\/cercor\/bhae282","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T11:42:36Z","timestamp":1720611756000},"source":"Crossref","is-referenced-by-count":3,"title":["Causal effects of hypertensive disorders of pregnancy on structural changes in specific brain regions: a Mendelian randomization study"],"prefix":"10.1093","volume":"34","author":[{"given":"Shanshan","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology , , 58 Zhongshan Road II, Guangzhou 510080 , China"},{"name":"The First Affiliated Hospital of Sun Yat-sen University , , 58 Zhongshan Road II, Guangzhou 510080 , China"},{"name":"Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases , 58 Zhongshan Road II, Guangzhou 510080 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , , 58 Zhongshan Road II, Guangzhou 510080 , China"},{"name":"The First Affiliated Hospital of Sun Yat-sen University , , 58 Zhongshan Road II, Guangzhou 510080 , China"},{"name":"Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases , 58 Zhongshan Road II, Guangzhou 510080 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaole","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , , 58 Zhongshan Road II, Guangzhou 510080 , China"},{"name":"The First Affiliated Hospital of Sun Yat-sen University , , 58 Zhongshan Road II, Guangzhou 510080 , China"},{"name":"Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases , 58 Zhongshan Road II, Guangzhou 510080 , 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