{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:23:08Z","timestamp":1788456188285,"version":"build-2803163510"},"reference-count":101,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Moonshot R&D","award":["JPMJMS2021"],"award-info":[{"award-number":["JPMJMS2021"]}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["JP23wm0625001"],"award-info":[{"award-number":["JP23wm0625001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["JP18dm0307004"],"award-info":[{"award-number":["JP18dm0307004"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["JP18dm0307001"],"award-info":[{"award-number":["JP18dm0307001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["JP19dm0207069"],"award-info":[{"award-number":["JP19dm0207069"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"name":"JSPS KAKENHI","award":["JP22K18419"],"award-info":[{"award-number":["JP22K18419"]}]},{"name":"JSPS KAKENHI","award":["JP22H04926"],"award-info":[{"award-number":["JP22H04926"]}]},{"name":"JSPS KAKENHI","award":["JP21H05174"],"award-info":[{"award-number":["JP21H05174"]}]},{"name":"JSPS KAKENHI","award":["JP21H05171"],"award-info":[{"award-number":["JP21H05171"]}]},{"name":"JSPS KAKENHI","award":["JP20H03596"],"award-info":[{"award-number":["JP20H03596"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Discrepancies in self-rated and observer-rated depression severity may underlie the basis for biological heterogeneity in depressive disorders and be an important predictor of outcomes and indicators to optimize intervention strategies. However, the neural mechanisms underlying this discrepancy have been understudied. This study aimed to examine the brain networks that represent the neural basis of the discrepancy between self-rated and observer-rated depression severity using resting-state functional MRI. To examine the discrepancy between self-rated and observer-rated depression severity, self- and observer-ratings discrepancy (SOD) was defined, and the higher and lower SOD groups were selected from depressed patients as participants showing extreme deviation. Resting-state functional MRI analysis was performed to examine regions with significant differences in functional connectivity in the two groups. The results showed that, in the higher SOD group compared to the lower SOD group, there was increased functional connectivity between the frontal pole and precuneus, both of which are subregions of the default mode network that have been reported to be associated with ruminative and self-referential thinking. These results provide insight into the association of brain circuitry with discrepancies between self- and observer-rated depression severity and may lead to more treatment-oriented diagnostic reclassification in the future.<\/jats:p>","DOI":"10.1093\/cercor\/bhae284","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T05:16:43Z","timestamp":1721884603000},"source":"Crossref","is-referenced-by-count":9,"title":["Frontal pole\u2013precuneus connectivity is associated with a discrepancy between self-rated and observer-rated depression severity in mood disorders: a resting-state functional magnetic resonance imaging study"],"prefix":"10.1093","volume":"34","author":[{"given":"Shintaro","family":"Kawakami","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry , Graduate School of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"},{"name":"The University of Tokyo , Graduate School of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8338-2758","authenticated-orcid":false,"given":"Naohiro","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry , Graduate School of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"},{"name":"The University of Tokyo , Graduate School of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"},{"name":"The International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo Institutes for Advanced Study (UTIAS) , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Satomura","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry , Graduate School of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"},{"name":"The University of Tokyo , Graduate School of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"},{"name":"Center for Diversity in Medical Education and Research (CDMER) , Graduate School of Medicine and Faculty of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"},{"name":"The University of Tokyo , Graduate School of Medicine and Faculty of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eimu","family":"Shoji","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry , Graduate School of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"},{"name":"The University of Tokyo , Graduate School of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry , Graduate School of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"},{"name":"The University of Tokyo , Graduate School of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Kiyota","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry , Graduate School of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"},{"name":"The University of Tokyo , Graduate School of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Favour","family":"Omileke","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry , Graduate School of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"},{"name":"The University of Tokyo , Graduate School of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Hamamoto","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry , Graduate School of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"},{"name":"The University of Tokyo , Graduate School of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry , Graduate School of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"},{"name":"The University of Tokyo , Graduate School of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Koshiyama","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry , Graduate School of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"},{"name":"The University of Tokyo , Graduate School of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Yamagishi","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry , Graduate School of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"},{"name":"The University of Tokyo , Graduate School of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eisuke","family":"Sakakibara","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry , Graduate School of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"},{"name":"The University of Tokyo , Graduate School of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsuke","family":"Koike","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry , Graduate School of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"},{"name":"The University of Tokyo , Graduate School of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"},{"name":"The International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo Institutes for Advanced Study (UTIAS) , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 , Japan"},{"name":"University of Tokyo Institute for Diversity & Adaptation of Human Mind (UTIDAHM) , 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902 , Japan"},{"name":"Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences , The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoto","family":"Kasai","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry , Graduate School of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"},{"name":"The University of Tokyo , Graduate School of Medicine, , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 , Japan"},{"name":"The 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