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However, less is known about the thalamocortical circuit in the rare subtype of early-onset schizophrenia. A total of 110 participants with early-onset schizophrenia (47 antipsychotic\u2013naive patients) and 70 matched healthy controls were recruited and underwent resting-state functional and diffusion-weighted magnetic resonance imaging scans. A data-driven parcellation method that combined the high spatial resolution of diffusion magnetic resonance imaging and the high sensitivity of functional magnetic resonance imaging was used to divide the thalamus. Next, the functional connectivity between each thalamic subdivision and the cortex\/cerebellum was investigated. Compared to healthy controls, individuals with early-onset schizophrenia exhibited hypoconnectivity between subdivisions of the thalamus and the frontoparietal network, visual network, ventral attention network, somatomotor network and cerebellum, and hyperconnectivity between subdivisions of thalamus and the parahippocampal and temporal gyrus, which were included in limbic network. The functional connectivity between the right posterior cingulate cortex and 1 subdivision of the thalamus (region of interest 1) was positively correlated with the general psychopathology scale score. This study showed that the specific thalamocortical dysconnection in individuals with early-onset schizophrenia involves the prefrontal, auditory and visual cortices, and cerebellum. This study identified thalamocortical connectivity as a potential biomarker and treatment target for early-onset schizophrenia.<\/jats:p>","DOI":"10.1093\/cercor\/bhae313","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T18:45:25Z","timestamp":1722969925000},"source":"Crossref","is-referenced-by-count":7,"title":["Dysfunction of thalamocortical circuits in early-onset schizophrenia"],"prefix":"10.1093","volume":"34","author":[{"given":"Jia","family":"Cai","sequence":"first","affiliation":[{"name":"West China Hospital of Sichuan University Mental Health Center, , No. 28th Dianxin Nan Str. Chengdu, Sichuan, 610041 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Xie","sequence":"additional","affiliation":[{"name":"West China Hospital of Sichuan University Mental Health Center, , No. 28th Dianxin Nan Str. 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