{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T10:37:07Z","timestamp":1769510227741,"version":"3.49.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-NMOSD) is an autoimmune disease characterized by suboptimal recovery from attacks and long-term disability. Experimental data suggest that AQP4 antibodies can disrupt neuroplasticity, a fundamental driver of brain recovery. A well-established method to assess brain LTP is through intermittent theta-burst stimulation (iTBS). This study aimed to explore neuroplasticity in AQP4-NMOSD patients by examining long-term potentiation (LTP) through iTBS. We conducted a proof-of-principle study including 8 patients with AQP4-NMOSD, 8 patients with multiple sclerosis (MS), and 8 healthy controls (HC) in which iTBS was administered to induce LTP-like effects. iTBS-induced LTP exhibited significant differences among the 3 groups (p: 0.006). Notably, AQP4-NMOSD patients demonstrated impaired plasticity compared to both HC (p\u2009=\u20090.01) and pwMS (p\u2009=\u20090.02). This pilot study provides the first in vivo evidence supporting impaired neuroplasticity in AQP4-NMOSD patients. Impaired cortical plasticity may hinder recovery following attacks suggesting a need for targeted rehabilitation strategies.<\/jats:p>","DOI":"10.1093\/cercor\/bhae345","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T23:16:10Z","timestamp":1724368570000},"source":"Crossref","is-referenced-by-count":2,"title":["Cortical plasticity in AQP4-positive NMOSD: a transcranial magnetic stimulation study"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2631-4185","authenticated-orcid":false,"given":"Alessandro","family":"Cruciani","sequence":"first","affiliation":[{"name":"Universit\u00e0 Campus Bio-Medico di Roma, Via Alvaro del Portillo 21-00128 Department of Medicine and Surgery, Unit of Neurology, Neurophysiology, Neurobiology, and Psychiatry, , Roma, Italy"},{"name":"Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo , 21-00128 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fioravante","family":"Capone","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Campus Bio-Medico di Roma, Via Alvaro del Portillo 21-00128 Department of Medicine and Surgery, Unit of Neurology, Neurophysiology, Neurobiology, and Psychiatry, , Roma, Italy"},{"name":"Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo , 21-00128 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shalom","family":"Haggiag","sequence":"additional","affiliation":[{"name":"San Camillo-Forlanini Hospital, C.ne Gianicolense 87, Department of Neurosciences, , 00152 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Prosperini","sequence":"additional","affiliation":[{"name":"San Camillo-Forlanini Hospital, C.ne Gianicolense 87, Department of Neurosciences, , 00152 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Santoro","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Campus Bio-Medico di Roma, Via Alvaro del Portillo 21-00128 Department of Medicine and Surgery, Unit of Neurology, Neurophysiology, Neurobiology, and Psychiatry, , Roma, Italy"},{"name":"Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo , 21-00128 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Ruggieri","sequence":"additional","affiliation":[{"name":"San Camillo-Forlanini Hospital, C.ne Gianicolense 87, Department of Neurosciences, , 00152 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Motolese","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Campus Bio-Medico di Roma, Via Alvaro del Portillo 21-00128 Department of Medicine and Surgery, Unit of Neurology, Neurophysiology, Neurobiology, and Psychiatry, , Roma, Italy"},{"name":"Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo , 21-00128 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Pilato","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Campus Bio-Medico di Roma, Via Alvaro del Portillo 21-00128 Department of Medicine and Surgery, Unit of Neurology, Neurophysiology, Neurobiology, and Psychiatry, , Roma, Italy"},{"name":"Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo , 21-00128 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Musumeci","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Campus Bio-Medico di Roma, Via Alvaro del Portillo 21-00128 Department of Medicine and Surgery, Unit of Neurology, Neurophysiology, Neurobiology, and Psychiatry, , Roma, Italy"},{"name":"Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo , 21-00128 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Pozzilli","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Campus Bio-Medico di Roma, Via Alvaro del Portillo 21-00128 Department of Medicine and Surgery, Unit of Neurology, Neurophysiology, Neurobiology, and Psychiatry, , Roma, Italy"},{"name":"Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo , 21-00128 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariagrazia","family":"Rossi","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Campus Bio-Medico di Roma, Via Alvaro del Portillo 21-00128 Department of Medicine and Surgery, Unit of Neurology, Neurophysiology, Neurobiology, and Psychiatry, , Roma, Italy"},{"name":"Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo , 21-00128 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Stampanoni Bassi","sequence":"additional","affiliation":[{"name":"Unit of Neurology, IRCCS Neuromed , Pozzilli (IS), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Buttari","sequence":"additional","affiliation":[{"name":"Unit of Neurology, IRCCS Neuromed , Pozzilli (IS), Italy"},{"name":"University of Tor Vergata Laboratory of Synaptic Immunopathology, Department of Systems Medicine, , Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Centonze","sequence":"additional","affiliation":[{"name":"Unit of Neurology, IRCCS Neuromed , Pozzilli (IS), Italy"},{"name":"University of Tor Vergata Laboratory of Synaptic Immunopathology, Department of Systems Medicine, , Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Di Lazzaro","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Campus Bio-Medico di Roma, Via Alvaro del Portillo 21-00128 Department of Medicine and Surgery, Unit of Neurology, Neurophysiology, Neurobiology, and Psychiatry, , Roma, Italy"},{"name":"Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo , 21-00128 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Gasperini","sequence":"additional","affiliation":[{"name":"San Camillo-Forlanini Hospital, C.ne Gianicolense 87, Department of Neurosciences, , 00152 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Tortorella","sequence":"additional","affiliation":[{"name":"San Camillo-Forlanini Hospital, C.ne Gianicolense 87, Department of Neurosciences, , 00152 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"2024082219174271500_ref1","doi-asserted-by":"crossref","first-page":"577236","DOI":"10.1016\/j.jneuroim.2020.577236","article-title":"Risk factors of attacks in neuromyelitis optica spectrum disorders","volume":"343","author":"Akaishi","year":"2020","journal-title":"J Neuroimmunol"},{"key":"2024082219174271500_ref2","doi-asserted-by":"crossref","first-page":"101494","DOI":"10.1016\/j.msard.2019.101494","article-title":"Cortical M1 plasticity and metaplasticity in patients with multiple sclerosis","volume":"38","author":"Baione","year":"2020","journal-title":"Multiple Sclerosis and Related Disorders"},{"issue":"3","key":"2024082219174271500_ref3","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nrn2575","article-title":"Complex brain networks: graph theoretical analysis of structural and functional systems","volume":"10","author":"Bullmore","year":"2009","journal-title":"Nat Rev Neurosci"},{"issue":"12","key":"2024082219174271500_ref4","doi-asserted-by":"crossref","first-page":"e2137833","DOI":"10.1001\/jamanetworkopen.2021.37833","article-title":"Frequency of new silent MRI lesions in myelin oligodendrocyte glycoprotein antibody disease and Aquaporin-4 antibody Neuromyelitis Optica Spectrum disorder","volume":"4","author":"Camera","year":"2021","journal-title":"JAMA Netw Open"},{"issue":"6","key":"2024082219174271500_ref5","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1007\/s00415-009-5047-0","article-title":"Intracortical excitability in patients with relapsing-remitting and secondary progressive multiple sclerosis","volume":"256","author":"Conte","year":"2009","journal-title":"J Neurol"},{"issue":"10","key":"2024082219174271500_ref6","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1177\/1352458515619780","article-title":"Attention-related changes in short-term cortical plasticity help to explain fatigue in multiple sclerosis","volume":"22","author":"Conte","year":"2016","journal-title":"Mult Scler"},{"issue":"6","key":"2024082219174271500_ref7","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1093\/brain\/awac480","article-title":"Clinical and MRI measures to identify non-acute MOG-antibody disease in adults","volume":"146","author":"Cortese","year":"2023","journal-title":"Brain"},{"issue":"4","key":"2024082219174271500_ref8","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.neuroscience.2009.08.034","article-title":"Live-cell imaging of aquaporin-4 diffusion and interactions in orthogonal arrays of particles","volume":"168","author":"Crane","year":"2010","journal-title":"Neuroscience"},{"issue":"7","key":"2024082219174271500_ref9","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/S1388-2457(99)00060-7","article-title":"The diagnostic value of motor evoked potentials","volume":"110","author":"Di Lazzaro","year":"1999","journal-title":"Clin Neurophysiol"},{"issue":"16","key":"2024082219174271500_ref10","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1113\/jphysiol.2008.152736","article-title":"The physiological basis of the effects of intermittent theta burst stimulation of the human motor cortex","volume":"586","author":"Di Lazzaro","year":"2008","journal-title":"J Physiol"},{"issue":"10","key":"2024082219174271500_ref11","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrneurol.2014.162","article-title":"Modulation of brain plasticity in stroke: a novel model for neurorehabilitation","volume":"10","author":"Di Pino","year":"2014","journal-title":"Nat Rev Neurol"},{"key":"2024082219174271500_ref12","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fnagi.2011.00005","article-title":"Changes in cortical plasticity across the lifespan","volume":"3","author":"Freitas","year":"2011","journal-title":"Front Aging Neurosci"},{"issue":"5","key":"2024082219174271500_ref13","doi-asserted-by":"crossref","first-page":"e841","DOI":"10.1212\/NXI.0000000000000841","article-title":"Interleukin-6 in neuromyelitis optica spectrum disorder pathophysiology","volume":"7","author":"Fujihara","year":"2020","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"issue":"4","key":"2024082219174271500_ref14","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1212\/WNL.0000000000006810","article-title":"Unraveling treatment response in multiple sclerosis: a clinical and MRI challenge","volume":"92","author":"Gasperini","year":"2019","journal-title":"Neurology"},{"issue":"4","key":"2024082219174271500_ref15","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nrneurol.2018.14","article-title":"The current role of MRI in differentiating multiple sclerosis from its imaging mimics","volume":"14","author":"Geraldes","year":"2018","journal-title":"Nat Rev Neurol"},{"issue":"6","key":"2024082219174271500_ref16","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1016\/j.brs.2020.09.004","article-title":"Age-related differences of motor cortex plasticity in adults: a transcranial direct current stimulation study","volume":"13","author":"Ghasemian-Shirvan","year":"2020","journal-title":"Brain Stimulation"},{"issue":"6","key":"2024082219174271500_ref17","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1093\/brain\/aws109","article-title":"Prognostic factors and disease course in aquaporin-4 antibody-positive patients with neuromyelitis optica spectrum disorder from the United Kingdom and Japan","volume":"135","author":"Kitley","year":"2012","journal-title":"Brain"},{"issue":"11","key":"2024082219174271500_ref18","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1212\/WNL.33.11.1444","article-title":"Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS)","volume":"33","author":"Kurtzke","year":"1983","journal-title":"Neurology"},{"issue":"23","key":"2024082219174271500_ref19","doi-asserted-by":"crossref","first-page":"e3124","DOI":"10.1212\/WNL.0000000000010847","article-title":"Incidence of interattack asymptomatic brain lesions in NMO spectrum disorder","volume":"95","author":"Lee","year":"2020","journal-title":"Neurology"},{"issue":"9451","key":"2024082219174271500_ref20","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1016\/S0140-6736(04)17551-X","article-title":"A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis","volume":"364","author":"Lennon","year":"2004","journal-title":"Lancet"},{"issue":"2","key":"2024082219174271500_ref21","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3390\/cells8020090","article-title":"Aquaporin-4 Water Channel in the brain and its implication for health and disease","volume":"8","author":"Mader","year":"2019","journal-title":"Cells"},{"key":"2024082219174271500_ref22","doi-asserted-by":"crossref","first-page":"105434","DOI":"10.1016\/j.neubiorev.2023.105434","article-title":"Somatosensory input in the context of transcranial magnetic stimulation coupled with electroencephalography: an evidence-based overview","volume":"155","author":"Mancuso","year":"2023","journal-title":"Neurosci Biobehav Rev"},{"key":"2024082219174271500_ref23","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jns.2016.06.036","article-title":"Recovery from optic neuritis attack in neuromyelitis optica spectrum disorder and multiple sclerosis","volume":"367","author":"Masuda","year":"2016","journal-title":"J Neurol Sci"},{"issue":"49","key":"2024082219174271500_ref24","doi-asserted-by":"crossref","first-page":"19112","DOI":"10.1523\/JNEUROSCI.2536-13.2013","article-title":"Synaptic plasticity and PDGF signaling defects underlie clinical progression in multiple sclerosis","volume":"33","author":"Mori","year":"2013","journal-title":"J Neurosci"},{"issue":"4","key":"2024082219174271500_ref25","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1177\/1352458513512541","article-title":"Cortical plasticity predicts recovery from relapse in multiple sclerosis","volume":"20","author":"Mori","year":"2014","journal-title":"Mult Scler"},{"issue":"12","key":"2024082219174271500_ref26","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1177\/15459683221138743","article-title":"May dual transcranial direct current stimulation enhance the efficacy of robot-assisted therapy for promoting upper limb recovery in chronic stroke?","volume":"36","author":"Morone","year":"2022","journal-title":"Neurorehabil Neural Repair"},{"key":"2024082219174271500_ref41","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1002\/glia.20855","article-title":"Aquaporin-4 orthogonal arrays of particles are the target for neuromyelitis optica autoantibodies","volume":"57","author":"Nicchia","year":"2009","journal-title":"Glia"},{"issue":"1","key":"2024082219174271500_ref27","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0028-3932(71)90067-4","article-title":"The assessment and analysis of handedness: the Edinburgh inventory","volume":"9","author":"Oldfield","year":"1971","journal-title":"Neuropsychologia"},{"issue":"4","key":"2024082219174271500_ref28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nrn3468","article-title":"Aquaporin water channels in the nervous system","volume":"14","author":"Papadopoulos","year":"2013","journal-title":"Nat Rev Neurosci"},{"issue":"3","key":"2024082219174271500_ref29","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.neuron.2013.11.023","article-title":"Crossmodal induction of thalamocortical potentiation leads to enhanced information processing in the auditory cortex","volume":"81","author":"Petrus","year":"2014","journal-title":"Neuron"},{"issue":"7","key":"2024082219174271500_ref30","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1177\/1352458518778008","article-title":"Cross-modal plasticity among sensory networks in neuromyelitis optica spectrum disorders","volume":"25","author":"Rocca","year":"2019","journal-title":"Mult Scler"},{"issue":"1","key":"2024082219174271500_ref31","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.clinph.2020.10.003","article-title":"Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: expert guidelines","volume":"132","author":"Rossi","year":"2021","journal-title":"Clin Neurophysiol"},{"issue":"7","key":"2024082219174271500_ref32","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.neuint.2013.05.003","article-title":"Aquaporin-4 water channels and synaptic plasticity in the hippocampus","volume":"63","author":"Scharfman","year":"2013","journal-title":"Neurochem Int"},{"issue":"1","key":"2024082219174271500_ref33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00221-002-1234-2","article-title":"Transcranial magnetic stimulation: new insights into representational cortical plasticity","volume":"148","author":"Siebner","year":"2003","journal-title":"Exp Brain Res"},{"issue":"10","key":"2024082219174271500_ref34","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1177\/1545968319868713","article-title":"Interleukin-6 disrupts synaptic plasticity and impairs tissue damage compensation in multiple sclerosis","volume":"33","author":"Stampanoni Bassi","year":"2019","journal-title":"Neurorehabil Neural Repair"},{"issue":"3","key":"2024082219174271500_ref35","doi-asserted-by":"crossref","first-page":"e16071","DOI":"10.1111\/ene.16071","article-title":"Preventive exercise and physical rehabilitation promote long-term potentiation-like plasticity expression in patients with multiple sclerosis","volume":"31","author":"Stampanoni Bassi","year":"2024","journal-title":"Eur J Neurol"},{"key":"2024082219174271500_ref36","doi-asserted-by":"crossref","DOI":"10.3389\/fnint.2016.00008","article-title":"The role of astrocytic Aquaporin-4 in synaptic plasticity and learning and memory","volume":"10","author":"Szu","year":"2016","journal-title":"Front Integr Neurosci"},{"issue":"2","key":"2024082219174271500_ref37","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(17)30470-2","article-title":"Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria","volume":"17","author":"Thompson","year":"2018","journal-title":"The Lancet Neurology"},{"issue":"2","key":"2024082219174271500_ref38","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1212\/WNL.0000000000001729","article-title":"International consensus diagnostic criteria for neuromyelitis optica spectrum disorders","volume":"85","author":"Wingerchuk","year":"2015","journal-title":"Neurology"},{"issue":"6","key":"2024082219174271500_ref39","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/00019052-199812000-00008","article-title":"Lesion-induced plasticity as a potential mechanism for recovery and rehabilitative training","volume":"11","author":"Witte","year":"1998","journal-title":"Curr Opin Neurol"},{"issue":"6","key":"2024082219174271500_ref40","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1177\/1352458515599246","article-title":"Relevance of asymptomatic spinal MRI lesions in patients with multiple sclerosis","volume":"22","author":"Zecca","year":"2016","journal-title":"Mult Scler"}],"container-title":["Cerebral Cortex"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cercor\/article-pdf\/34\/8\/bhae345\/58885890\/bhae345.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cercor\/article-pdf\/34\/8\/bhae345\/58885890\/bhae345.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T23:16:30Z","timestamp":1724368590000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cercor\/article\/doi\/10.1093\/cercor\/bhae345\/7738459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,1]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cercor\/bhae345","relation":{},"ISSN":["1047-3211","1460-2199"],"issn-type":[{"value":"1047-3211","type":"print"},{"value":"1460-2199","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,8]]},"published":{"date-parts":[[2024,8,1]]},"article-number":"bhae345"}}