{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T09:20:01Z","timestamp":1760347201847,"version":"3.41.2"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52073310"],"award-info":[{"award-number":["52073310"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Peking University People\u2019s Hospital Talent Introduction Scientific Research Launch Fund","award":["2022-T-02"],"award-info":[{"award-number":["2022-T-02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Inflammation may be related to structural changes in the cerebral cortex. We aimed to explore whether cytokines mediate the link between these changes and primary headache. The summary statistics of genome-wide association study (GWAS) related to migraine and its subtypes, cluster headache were derived from the FinnGen Release 10 database, and tension-type headache data was from the GWAS Catalog. Ninety-one cytokines were obtained from genome-wide pQTL mapping data. GWAS data on cortical surface area (SA) and thickness (TH) came from the ENIGMA Consortium. The methods of Mendelian randomization (MR) analysis included the inverse-variance-weighted (IVW), MR-Egger, and weighted median. Migraine reduces the SA of paracentral[\u03b2\u2009=\u2009\u22121.3645, OR\u2009=\u20090.2555, 95%CI (0.0660, 0.9898)] by fibroblast growth factor-23(FGF-23), with an intermediate ratio (IR) of 38.13%. Migraine may reduce the TH of superior parietal[\u03b2\u2009=\u2009\u22120.0029, OR\u2009=\u20090.9971, 95%CI (0.9943, 0.9999)] by interleukin (IL)-15RA, with an absolute IR of 11.11%. Migraine without aura may reduce the TH of rostral anterior cingulate[\u03b2\u2009=\u2009\u22120.0005, OR\u2009=\u20090.9995, 95%CI (0.9991, 0.9999)] by IL-18R1, with an IR of 11.63%. FGF23 and IL-15RA are associated with reduced SA or TH in migraine, while IL-18R1 is associated with increased TH in migraine without aura.<\/jats:p>","DOI":"10.1093\/cercor\/bhae349","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T03:44:11Z","timestamp":1726199051000},"source":"Crossref","is-referenced-by-count":3,"title":["Causal relationship between primary headache mediated by circulating cytokines and cerebral cortex structure: a mediation Mendelian randomization study"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4241-5584","authenticated-orcid":false,"given":"Tao","family":"Zheng","sequence":"first","affiliation":[{"name":"Beijing University of Chinese Medicine , No. 11 Beisanhuan East Road, Heping Street, Chaoyang District, Beijing, 100029, China"},{"name":"Department of Brain Disease III, Dongfang Hospital Beijing University of Chinese Medicine , No. 6, Fangxingyuan District 1, Fangzhuang, Fengtai District, Beijing, 100078, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Zeng","sequence":"additional","affiliation":[{"name":"Shaodong People's Hospital , 95 Renmin Road, Shaodong City, Hunan Province, 422800, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanglu","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine , No. 11 Beisanhuan East Road, Heping Street, Chaoyang District, Beijing, 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shicheng","family":"Lin","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine , No. 11 Beisanhuan East Road, Heping Street, Chaoyang District, Beijing, 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binyang","family":"Yu","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine , No. 11 Beisanhuan East Road, Heping Street, Chaoyang District, Beijing, 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Yuan","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine , No. 11 Beisanhuan East Road, Heping Street, Chaoyang District, Beijing, 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaojie","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Taizhou Central Hospital (Taizhou University Hospital) , No. 999 Donghai Avenue, Jiaojiang Economic Development Zone, Taizhou, 317700, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gesheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Brain Disease III, Dongfang Hospital Beijing University of Chinese Medicine , No. 6, Fangxingyuan District 1, Fangzhuang, Fengtai District, Beijing, 100078, 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