{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:46:03Z","timestamp":1753875963255,"version":"3.41.2"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Practice and Innovation Project of Harbin Medical University","award":["YJSCX2024-27HYD","YJSCX2024-101HYD"],"award-info":[{"award-number":["YJSCX2024-27HYD","YJSCX2024-101HYD"]}]},{"name":"Outstanding Youth Funding of Harbin Medical University","award":["HYD2020JQ0016"],"award-info":[{"award-number":["HYD2020JQ0016"]}]},{"name":"Research project of Heilongjiang Provincial Health Commission","award":["2022-130"],"award-info":[{"award-number":["2022-130"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundations of China","doi-asserted-by":"crossref","award":["82071368","82271340"],"award-info":[{"award-number":["82071368","82271340"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The occurrence mechanism of intracerebral hemorrhage remains unclear. Several recent studies have highlighted the close relationship between environmental senses and intracerebral hemorrhage, but the mechanisms of causal mediation are inconclusive. We aimed to investigate the causal relationships and potential mechanisms between environmental senses and intracerebral hemorrhage. Multiple Mendelian randomization methods were used to identify a causal relationship between environmental senses and intracerebral hemorrhage. Gut microbiota and brain imaging phenotypes were used to find possible mediators. Enrichment and molecular interaction analyses were used to identify potential mediators and molecular targets. No causal relationship between temperature and visual perception with intracerebral hemorrhage was found, whereas long-term noise was identified as a risk factor for intracerebral hemorrhage (OR 2.95, 95% CI: 1.25 to 6.93, PIVW\u2009=\u20090.01). The gut microbiota belonging to the class Negativicutes and the order Selenomonadales and the brain image\u2013derived phenotypes ICA100 node 54, edge 803, edge 1149, and edge 1323 played mediating roles. \u201cRegulation of signaling and function in synaptic organization\u201d is the primary biological pathway of noise-induced intracerebral hemorrhage, and ARHGAP22 may be the critical gene. This study emphasized the importance of environmental noise in the prevention, disease management, and underlying biological mechanisms of intracerebral hemorrhage.<\/jats:p>","DOI":"10.1093\/cercor\/bhae377","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T01:19:51Z","timestamp":1726449591000},"source":"Crossref","is-referenced-by-count":0,"title":["Exploring causal effects and potential mediating mechanisms of genetically linked environmental senses with intracerebral hemorrhage"],"prefix":"10.1093","volume":"34","author":[{"given":"Yaolou","family":"Wang","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Harbin Medical University Department of Neurosurgery, , No. 23 Post Street, Nangang District, Harbin, Heilongjiang 150001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingjie","family":"Shen","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Harbin Medical University Department of Neurosurgery, , No. 23 Post Street, Nangang District, Harbin, Heilongjiang 150001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinru","family":"Shen","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Harbin Medical University Department of Neurology, , No. 23 Post Street, Nangang District, Harbin, Heilongjiang 150001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoxin","family":"Fan","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Harbin Medical University Department of Neurosurgery, , No. 23 Post Street, Nangang District, Harbin, Heilongjiang 150001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Harbin Medical University Department of Neurosurgery, , No. 23 Post Street, Nangang District, Harbin, Heilongjiang 150001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Northeast Agricultural University School of Life Science, , No. 600 Changjiang Road, Xiangfang District, Harbin, Heilongjiang 150030, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Lv","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Harbin Medical University Department of Rehabilitation Medicine, , No. 23 Post Street, Nangang District, Harbin, Heilongjiang 150001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Ma","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Harbin Medical University Department of Neurosurgery, , No. 23 Post Street, Nangang District, Harbin, Heilongjiang 150001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8735-7059","authenticated-orcid":false,"given":"Hongsheng","family":"Liang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Harbin Medical University Department of Neurosurgery, , No. 23 Post Street, Nangang District, Harbin, Heilongjiang 150001, P.R. China"},{"name":"NHC Key Laboratory of Cell Transplantation , No. 23 Post Street, Nangang District, Harbin 150001, Heilongjiang, P.R. 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