{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:01:51Z","timestamp":1776729711080,"version":"3.51.2"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":23,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["82302159"],"award-info":[{"award-number":["82302159"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["82027808"],"award-info":[{"award-number":["82027808"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["81820108018"],"award-info":[{"award-number":["81820108018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["81621003"],"award-info":[{"award-number":["81621003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>While some studies have used a transdiagnostic approach to relate depression to metabolic or functional brain alterations, the structural substrate of depression across clinical diagnostic categories is underexplored. In a cross-sectional study of 52 patients with major depressive disorder and 51 with post-traumatic stress disorder, drug-na\u00efve, and spanning mild to severe depression severity, we examined transdiagnostic depressive correlates with regional gray matter volume and the topological properties of gray matter-based networks. Locally, transdiagnostic depression severity correlated positively with gray matter volume in the right middle frontal gyrus and negatively with nodal topological properties of gray matter-based networks in the right amygdala. Globally, transdiagnostic depression severity correlated positively with normalized characteristic path length, a measure implying brain integration ability. Compared with 62 healthy control participants, both major depressive disorder and post-traumatic stress disorder patients showed altered nodal properties in regions of the fronto\u2013limbic\u2013striatal circuit, and global topological organization in major depressive disorder in particular was characterized by decreased integration and segregation. These findings provide evidence for a gray matter-based structural substrate underpinning depression, with the prefrontal\u2013amygdala circuit a potential predictive marker for depressive symptoms across clinical diagnostic categories.<\/jats:p>","DOI":"10.1093\/cercor\/bhae381","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T12:49:22Z","timestamp":1727182162000},"source":"Crossref","is-referenced-by-count":2,"title":["Transdiagnostic depression severity and its relationship to global and prefrontal-amygdala structural properties in people with major depression and post-traumatic stress disorder"],"prefix":"10.1093","volume":"34","author":[{"given":"Lei","family":"Li","sequence":"first","affiliation":[{"name":"Huaxi MR Research Center , Department of Radiology, , Guoxuexiang 37#, Wuhou, Chengdu, 640041, China"},{"name":"West China Hospital of Sichuan University , Department of Radiology, , Guoxuexiang 37#, Wuhou, Chengdu, 640041, China"},{"name":"Research Unit of Psychoradiology, Chinese Academy of Medical Sciences , Guoxuexiang 37#, Wuhou, Chengdu, 640041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Research Unit of Psychoradiology, Chinese Academy of Medical Sciences , Guoxuexiang 37#, Wuhou, Chengdu, 640041, China"},{"name":"The Third People\u2019s Hospital , Yangshijie 19#, Qingyang, Chengdu, 610031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shitong","family":"Zhong","sequence":"additional","affiliation":[{"name":"West China School of Medicine, Sichuan University , Renminnanlu 16#, Wuhou, Chengdu, 640041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinping","family":"Lin","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center , Department of Radiology, , Guoxuexiang 37#, Wuhou, Chengdu, 640041, China"},{"name":"West China Hospital of Sichuan University , Department of Radiology, , Guoxuexiang 37#, Wuhou, Chengdu, 640041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhao","family":"Yao","sequence":"additional","affiliation":[{"name":"West China School of Medicine, Sichuan University , Renminnanlu 16#, Wuhou, Chengdu, 640041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham J","family":"Kemp","sequence":"additional","affiliation":[{"name":"Liverpool Magnetic Resonance Imaging Centre and Institute of Life Course and Medical Sciences, University of Liverpool , Foundation Building, Brownlow Hill, Liverpool, L69 7ZX, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4376-8744","authenticated-orcid":false,"given":"Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center , Department of Radiology, , Guoxuexiang 37#, Wuhou, Chengdu, 640041, China"},{"name":"West China 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