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The multivariate mixed-effects models were employed to analyze the correlation between geriatric depression scale scores, cognitive function, and imaging indicators. The sgmediation software package was utilized to analyze the mediating effects of imaging indicators. The geriatric depression scale was negatively correlated with Mini-Mental State Examination and Montreal Cognitive Assessment, and positively correlated with CDRSB, Alzheimer\u2019s Disease Assessment Scale11, and Alzheimer\u2019s Disease Assessment Scale13 when the subjects were not grouped. The geriatric depression scale was negatively correlated with Montreal Cognitive Assessment and positively correlated with Alzheimer\u2019s Disease Assessment Scal13 in groups with baseline diagnosis of early mild cognitive impairment and late mild cognitive impairment. Furthermore, depression was associated with regional imaging indicators, while cognitive function was linked to broad imaging indicators. Some of these indicators were related to both depression and cognitive function, playing a mediating role in their relationship. Depression was related to cognitive function, especially in subjects with mild cognitive impairment. Some imaging indicators may represent the underlying basis for the association between depression and cognitive function.<\/jats:p>","DOI":"10.1093\/cercor\/bhae423","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T12:51:29Z","timestamp":1729687889000},"source":"Crossref","is-referenced-by-count":4,"title":["Longitudinal association of depressive symptoms with cognition and neuroimaging biomarkers in cognitively unimpaired older adults, mild cognitive impairment, and Alzheimer\u2019s disease"],"prefix":"10.1093","volume":"34","author":[{"given":"Ying","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Radiology , West China Biomedical Big Data Center, West China Hospital, , No. 37 Guo Xue Alley, Chengdu, Sichuan, 610041 ,","place":["China"]},{"name":"Sichuan University , West China Biomedical Big Data Center, West China Hospital, , No. 37 Guo Xue Alley, Chengdu, Sichuan, 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhu","sequence":"additional","affiliation":[{"name":"West China Biomedical Big Data Center , West China Hospital, , No. 37 Guo Xue Alley, Chengdu, Sichuan, 610041 ,","place":["China"]},{"name":"Sichuan University , West China Hospital, , No. 37 Guo Xue Alley, Chengdu, Sichuan, 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minlan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Mental Health Center and Psychiatric Laboratory , the State Key Laboratory of Biotherapy, West China Hospital, , No. 37 Guo Xue Alley, Chengdu, Sichuan, 610041 ,","place":["China"]},{"name":"Sichuan University , the State Key Laboratory of Biotherapy, West China Hospital, , No. 37 Guo Xue Alley, Chengdu, Sichuan, 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongru","family":"Zhu","sequence":"additional","affiliation":[{"name":"Mental Health Center and Psychiatric Laboratory , the State Key Laboratory of Biotherapy, West China Hospital, , No. 37 Guo Xue Alley, Chengdu, Sichuan, 610041 ,","place":["China"]},{"name":"Sichuan University , the State Key Laboratory of Biotherapy, West China Hospital, , No. 37 Guo Xue Alley, Chengdu, Sichuan, 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3113-9577","authenticated-orcid":false,"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"West China Biomedical Big Data Center of West China Hospital , Med-X Center for Informatics, Mental Health Center of West China Hospital, , No. 37 Guo Xue Alley, Chengdu, Sichuan, 610041 ,","place":["China"]},{"name":"Sichuan University , Med-X Center for Informatics, Mental Health 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