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This study used two-sample Mendelian randomization (MR) with genetic variations as instrumental variables (IVs) to explore potential causal relationships between FC and BN. Summary data from genome-wide association studies (GWAS) involving 2,564 individuals were analyzed to identify genetically predicted BN. Functional magnetic resonance imaging parameters and materials were sourced from the UK Biobank. The variables underwent independent component analysis processing by the database to generate the final GWAS dataset. Various methods, including MR Pleiotropy RESidual Sum and Outlier, MR Egger, and weighted median, were employed to detect heterogeneity and pleiotropy, with inverse variance weighting serving as the principal estimation method (P\u2009&amp;lt;\u20090.05). The FC imaging-derived phenotypes revealed that BN exerted a causal influence on the FC between large-scale networks, including the visual network, default mode network (DMN), frontoparietal network, somatosensory network (SSN), and ventral attention network. Additionally, BN had a causal impact on the within-network FC of both the DMN and SSN. The study provides evidence that BN leads to further changes in FC patterns within and between large-scale brain networks.<\/jats:p>","DOI":"10.1093\/cercor\/bhae430","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T18:27:56Z","timestamp":1730917676000},"source":"Crossref","is-referenced-by-count":4,"title":["Changes in resting-state functional connectivity of large-scale brain networks in bulimia nervosa: evidence from causal analysis"],"prefix":"10.1093","volume":"34","author":[{"given":"Jiani","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital, Capital Medical University , No. 95 Yong An Road, Xicheng District, Beijing 100050 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital, Capital Medical University , No. 95 Yong An Road, Xicheng District, Beijing 100050 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital, Capital Medical University , No. 95 Yong An Road, Xicheng District, Beijing 100050 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital, Capital Medical University , No. 95 Yong An Road, Xicheng District, Beijing 100050 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanjiang","family":"Li","sequence":"additional","affiliation":[{"name":"The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University , No.\u00a05 Ankang Hutong, Xicheng District, Beijing 100088 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