{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:46:35Z","timestamp":1778622395694,"version":"3.51.4"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Government of India","doi-asserted-by":"publisher","award":["200126"],"award-info":[{"award-number":["200126"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Subjective tinnitus, characterized by the perception of phantom sounds in the absence of external stimuli, presents significant challenges in both audiology and neurology. Once thought to primarily involve aberrant neural activity within auditory pathways, it is now understood to engage a broader array of neuroanatomical structures. This study investigated the connections between auditory, cognitive, and sensory processing regions, which are crucial for unraveling the complex neurobiological basis of tinnitus. Using high-resolution T1-weighted magnetic resonance imaging, we compared 52 individuals with subjective tinnitus with 52 age-matched healthy controls, focusing on cerebral cortex features, including fractal dimensionality, gyrification, and sulcal depth. Covariate analyses were conducted to explore the relationships between tinnitus duration, Tinnitus Handicap Inventory scores, anxiety score, and neuroanatomical changes. We found significant alterations in key brain regions involved in sensory processing, cognition, and emotional regulation, including the insula, lateral occipital cortex, middle frontal gyrus, and superior parietal lobule. These neuroanatomical changes were strongly correlated with the severity and chronicity of tinnitus symptoms. Our findings reveal profound structural changes in the brain associated with subjective tinnitus, offering valuable insights into the condition\u2019s underlying mechanisms and providing a potential framework for guiding future research and therapeutic interventions.<\/jats:p>","DOI":"10.1093\/cercor\/bhae432","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T01:23:21Z","timestamp":1730942601000},"source":"Crossref","is-referenced-by-count":5,"title":["Neuroanatomical correlates of subjective tinnitus: insights from advanced cortical morphology analysis"],"prefix":"10.1093","volume":"34","author":[{"given":"Himanshu R","family":"Pandey","sequence":"first","affiliation":[{"name":"Department of Advanced Spectroscopy and Imaging, Centre of Bio-Medical Research, Sanjay Gandhi Postgraduate Institute of Medical Sciences Campus , Raebareli Road, Lucknow 226014,","place":["India"]},{"name":"Department of Physical and Biological Sciences, Academy of 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