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In this study, 66 participants with normal cognition, 59 with subjective cognitive decline, 12 with mild cognitive impairment, and 11 with Alzheimer\u2019s disease dementia were included in the Sino Longitudinal Study on Cognitive Decline (SILCODE) cohort. A regional asymmetry index, denoting the left\u2013right asymmetry of \u03b2-amyloid plaques, was derived for each region based on the Anatomical Automatic Labeling atlas. The level of \u03b2-amyloid plaques in each region was compared among different clinical stages of Alzheimer\u2019s disease using the analysis of variance. An additional correlation analysis examined the relationship between each region of interest\u2019s cognitive performance scores and asymmetry index values. We found that \u03b2-amyloid appears to be lateralized in different stages of Alzheimer\u2019s disease. In addition, there is a significant correlation between \u03b2-amyloid asymmetry in various brain regions and cognition. The observed A\u03b2 lateralization could potentially be utilized as a neuroimaging biomarker throughout AD progression.<\/jats:p>","DOI":"10.1093\/cercor\/bhae485","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T02:39:22Z","timestamp":1734921562000},"source":"Crossref","is-referenced-by-count":6,"title":["Asymmetrical patterns of \u03b2-amyloid deposition and cognitive changes in Alzheimer\u2019s disease: the SILCODE study"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7293-8776","authenticated-orcid":false,"given":"Xianfeng","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital of Capital Medical University , #45 Changchun Street, Xicheng District, Beijing 100053 ,","place":["China"]},{"name":"Department of Neurology, The First Affiliated Hospital of Anhui Medical University , #218 Jixi Road, Shushan District, Hefei 230022 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