{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:58:50Z","timestamp":1787313530339,"version":"build-2736575974"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20303"],"award-info":[{"award-number":["U22A20303"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61971451"],"award-info":[{"award-number":["61971451"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ6574"],"award-info":[{"award-number":["2024JJ6574"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinical Research Center for Medical Imaging in Hunan Province","award":["2020SK4001"],"award-info":[{"award-number":["2020SK4001"]}]},{"name":"Leading Talents of Scientific and Technological Innovation in Hunan Province in 2021","award":["2021RC4016"],"award-info":[{"award-number":["2021RC4016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u00a0<\/jats:title>\n                  <jats:p>Different addictive drugs can impact the function and morphology of the brain in diverse ways. The insula cortex, an important brain node involved in craving and reward neural circuits in individuals with substance use disorders (including damage to the insula cortex), has been reported to reduce addictive behaviors. However, less is known about whether there is a functional difference between individuals with opioid and methamphetamine use disorders, especially regarding the function of the insula cortex. Fifty-eight individuals with opioid use disorder and sixty individuals with methamphetamine use disorder underwent resting-state and 3D-T1-weighted magnetic resonance imaging and completed craving questionnaires. Differences in insula subdivision resting-state functional connectivity between the groups were assessed, and their correlations with craving were analyzed. Compared with the methamphetamine group, the opioid group demonstrated increased connectivity of the right dorsal anterior insula but decreased connectivity of the right posterior insula and the left dorsal anterior insula\/posterior insula\/ventral anterior insula. Additionally, a negative correlation between functional connectivity and craving was observed in individuals with opioid and methamphetamine use disorders. This study provides insights into the various brain function connection patterns that are associated with different types of drug use with respect to opioid and methamphetamine use disorders.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Highlights<\/jats:title>\n               <\/jats:sec>","DOI":"10.1093\/cercor\/bhaf014","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T05:25:42Z","timestamp":1740029142000},"source":"Crossref","is-referenced-by-count":4,"title":["Distinct insula subdivisions of resting-state functional connectivity in individuals with opioid and methamphetamine use disorders"],"prefix":"10.1093","volume":"35","author":[{"given":"Wenhan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Radiology, Second Xiangya Hospital of Central South University , No. 139 Renmin Middle Road, Furong District, Changsha 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710126,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longtao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Second Xiangya Hospital of Central South University , No. 139 Renmin Middle Road, Furong District, Changsha 410000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Second Xiangya Hospital of Central South University , No. 139 Renmin Middle Road, Furong District, Changsha 410000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"International Joint Research Center for Advanced Medical Imaging and Intelligent Diagnosis and Treatment & Xi\u2019an Key Laboratory of Intelligent Sensing and Regulation of Trans-Scale Life Information, School of Life Science and Technology, Xidian University , No. 266 Xinglong Section of Xi Feng Road, Xi'an 710126,","place":["China"]},{"name":"Hunan Judicial Police Academy , 1069 Yuanda 2nd Road, Furong District, Changsha 410131,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology, Xidian University , No. 266 Xinglong Section of Xi Feng Road, Xi'an 710126 ,","place":["China"]},{"name":"Engineering Research Center of Molecular and Neuroimaging, Ministry of Education , No. 266 Xinglong Section of Xi Feng Road, Xi'an 710126,","place":["China"]},{"name":"International Joint Research Center for Advanced Medical Imaging and Intelligent Diagnosis and Treatment & Xi\u2019an Key Laboratory of Intelligent Sensing and Regulation of Trans-Scale Life Information, School of Life Science and Technology, Xidian University , No. 266 Xinglong Section of Xi Feng Road, Xi'an 710126,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7851-6782","authenticated-orcid":false,"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Second Xiangya Hospital of Central South University , No. 139 Renmin Middle Road, Furong District, Changsha 410000,","place":["China"]},{"name":"Clinical Research Center for Medical Imaging in Hunan Province , No. 139 Renmin Middle Road, Furong District, Changsha 410000,","place":["China"]},{"name":"Department of Radiology Quality Control Center in Hunan Province , No. 139 Renmin Middle Road, Furong District, Changsha 410000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"key":"2025022005251280300_ref1","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/bs.irn.2020.11.013","article-title":"Anterior cingulate 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