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We aimed to investigate the hierarchical organization of the fusiform gyrus and its underlying molecular basis. Resting-state functional MRI data of 793 healthy subjects were collected from a discovery dataset and two independent cross-scanner, cross-race validation datasets. Functional gradients of the fusiform gyrus were calculated based on the voxel-wise fusiform gyrus-to-cerebrum functional connectivity to reflect its functional organization. Transcription-neuroimaging spatial correlation analysis was performed to determine genes with expression levels tracking the fusiform gyrus functional gradient. The dominant functional gradient that explained the greatest connectivity variance showed an anterior\u2013posterior axis across the fusiform gyrus. More important, there was a strong association between the fusiform gyrus\u2013dominant gradient and gene expression profiles, with two gene sets contributing significantly to this association yet differing in their specific expression and functional annotation. In addition, the fusiform gyrus\u2013dominant gradient was linked closely to intrinsic geometry, slightly to cortical morphology, and gradually to behavioral domains from high-level cognitive processes to low-level sensory functions. Our findings add to the extant knowledge regarding the topographic organization of the fusiform gyrus by informing a novel conceptualization of how functional heterogeneity and multiplicity co-occur within the fusiform gyrus.<\/jats:p>","DOI":"10.1093\/cercor\/bhaf029","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T15:11:41Z","timestamp":1740064301000},"source":"Crossref","is-referenced-by-count":5,"title":["Functional gradient of the fusiform gyrus and its underlying molecular basis"],"prefix":"10.1093","volume":"35","author":[{"given":"Jingyao","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Anhui Medical University , No. 218, Jixi Road, Shushan District, Hefei 230022 ,","place":["China"]},{"name":"Research Center of Clinical Medical Imaging , Anhui Province, No. 81, Meishan Road, Shushan District, Hefei 230032 ,","place":["China"]},{"name":"Anhui Provincial Institute of 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Jixi Road, Shushan District, Hefei 230022,","place":["China"]},{"name":"Research Center of Clinical Medical Imaging , Anhui Province, No. 81, Meishan Road, Shushan District, Hefei 230032 ,","place":["China"]},{"name":"Anhui Provincial Institute of Translational Medicine , No. 81, Meishan Road, Shushan District, Hefei 230032 ,","place":["China"]},{"name":"Anhui Provincial Key Laboratory for Brain Bank Construction and Resource Utilization , No. 81, Meishan Road, Shushan District, Hefei 230032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiology , The First Affiliated Hospital of Anhui Medical University, No. 218, Jixi Road, Shushan District, Hefei 230022,","place":["China"]},{"name":"Research Center of Clinical Medical Imaging , Anhui Province, No. 81, Meishan Road, Shushan District, Hefei 230032 ,","place":["China"]},{"name":"Anhui Provincial Institute of Translational Medicine , No. 81, Meishan Road, Shushan District, Hefei 230032 ,","place":["China"]},{"name":"Anhui Provincial Key Laboratory for Brain Bank Construction and Resource Utilization , No. 81, Meishan Road, Shushan District, Hefei 230032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8977-2215","authenticated-orcid":false,"given":"Yongqiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Radiology , The First Affiliated Hospital of Anhui Medical University, No. 218, Jixi Road, Shushan District, Hefei 230022,","place":["China"]},{"name":"Research Center of Clinical Medical Imaging , Anhui Province, No. 81, Meishan Road, Shushan District, Hefei 230032 ,","place":["China"]},{"name":"Anhui Provincial Institute of Translational Medicine , No. 81, Meishan Road, Shushan District, Hefei 230032 ,","place":["China"]},{"name":"Anhui Provincial Key Laboratory for Brain Bank Construction and 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