{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T16:58:04Z","timestamp":1778864284659,"version":"3.51.4"},"reference-count":95,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["#24\u00a0K06614"],"award-info":[{"award-number":["#24\u00a0K06614"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["#19KK0211"],"award-info":[{"award-number":["#19KK0211"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Embryonic exposure to valproic acid and imidacloprid (a neonicotinoid insecticide) impairs filial imprinting in hatchlings, and the deteriorating effects of valproic acid are mitigated by post-hatch injection of bumetanide, a blocker of the chloride intruder Na-K-2Cl cotransporter 1. Here, we report that these exposures depolarized the reversal potential of local GABAergic transmission in the neurons of the intermediate medial mesopallium, the pallial region critical for imprinting. Furthermore, exposure increased field excitatory post-synaptic potentials in pre-tetanus recordings and impaired long-term potentiation (LTP) by low-frequency tetanic stimulation. Bath-applied bumetanide rescued the impaired LTP in the valproic acid slices, whereas VU0463271, a blocker of the chloride extruder KCC2, suppressed LTP in the control slices, suggesting that hyperpolarizing GABA action is necessary for the potentiation of excitatory synaptic transmission. Whereas a steep increase in the gene expression of KCC2 appeared compared to NKCC1 during the peri-hatch development, significant differences were not found between valproic acid and control post-hatch chicks in these genes. Instead, both valproic acid and imidacloprid downregulated several transcriptional regulators (FOS, NR4A1, and NR4A2) and upregulated the RNA component of signal recognition particles (RN7SL1). Despite different chemical actions, valproic acid and imidacloprid could cause common neuronal effects that lead to impaired imprinting.<\/jats:p>","DOI":"10.1093\/cercor\/bhaf044","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T23:37:26Z","timestamp":1741131446000},"source":"Crossref","is-referenced-by-count":2,"title":["Embryonic exposure to valproic acid and neonicotinoid deteriorates the hyperpolarizing GABA shift and impairs long-term potentiation of excitatory transmission in the local circuit of intermediate medial mesopallium of chick telencephalon"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9404-647X","authenticated-orcid":false,"given":"Toshiya","family":"Matsushima","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Science, Hokkaido University , N10 W8 Kita-ku, 060-0810 Sapporo ,","place":["Japan"]},{"name":"Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido , Kanazawa 1757, 061-0293 Tobetsu ,","place":["Japan"]},{"name":"Center for Mind\/Brain Sciences, University of Trento , Piazza Manifattura 1, 38068 Rovereto ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Toji","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, Hokkaido University , N10 W8 Kita-ku, 060-0810 Sapporo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, Hokkaido University , N10 W8 Kita-ku, 060-0810 Sapporo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Shikanai","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido , Kanazawa 1757, 061-0293 Tobetsu ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Izumi","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido , Kanazawa 1757, 061-0293 Tobetsu ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,3,2]]},"reference":[{"key":"2025030423422540600_ref1","doi-asserted-by":"publisher","first-page":"733140","DOI":"10.3389\/fnbeh.2021.733140","article-title":"Spontaneous visual preference for face-like stimuli is impaired in newly-hatched domestic chicks exposed to valproic acid during embryogenesis","volume":"15","author":"Adiletta","year":"2021","journal-title":"Front Behav Neurosci"},{"key":"2025030423422540600_ref2","doi-asserted-by":"publisher","first-page":"16452","DOI":"10.1038\/s41598-017-15739-1","article-title":"Molecular architecture of potassium chloride co-transporter KCC2","volume":"7","author":"Agez","year":"2017","journal-title":"Sci Rep"},{"key":"2025030423422540600_ref4","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.tins.2017.07.001","article-title":"NKCC1 chloride importer antagonists attenuate many neurological and psychiatric disorders","volume":"40","author":"Ben-Ari","year":"2017","journal-title":"Trends in Neuroscience"},{"key":"2025030423422540600_ref5","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1177\/1073858412438697","article-title":"The GABA excitatory\/inhibitory shift in brain maturation and neurological disorders","volume":"18","author":"Ben-Ari","year":"2012","journal-title":"Neuroscientist"},{"key":"2025030423422540600_ref6","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1016\/j.neuron.2009.03.003","article-title":"Cation-chloride cotransporters and neuronal function","volume":"61","author":"Blaesse","year":"2009","journal-title":"Neuron"},{"key":"2025030423422540600_ref7","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1098\/rspb.1991.0004","article-title":"Potentiation of synaptic responses in slices from the chick forebrain","volume":"243","author":"Bradley","year":"1991","journal-title":"Proceedings of the Royal Society B Biological Sciences"},{"key":"2025030423422540600_ref8","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/s0166-4328(98)00092-8","article-title":"Electrophysiological correlates of past history: in vitro studies of the IMHV of the domestic chick","volume":"98","author":"Bradley","year":"1999","journal-title":"Behav Brain Res"},{"key":"2025030423422540600_ref9","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1136\/jnnp-2012-304270","article-title":"The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs","volume":"84","author":"Bromley","year":"2013","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2025030423422540600_ref10","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1159\/000509109","article-title":"A systematic review of the valproic acid-induced rodent model of autism","volume":"42","author":"Chaliha","year":"2020","journal-title":"Dev Neurosci"},{"key":"2025030423422540600_ref11","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.neuron.2014.05.027","article-title":"Activity-induced Nr4a1 regulates spine density and distribution pattern of excitatory synapses in pyramidal neurons","volume":"83","author":"Chen","year":"2014","journal-title":"Neuron"},{"key":"2025030423422540600_ref12","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1001\/jama.2013.2270","article-title":"Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism","volume":"309","author":"Christensen","year":"2013","journal-title":"JAMA J Am Med Assoc"},{"key":"2025030423422540600_ref13","doi-asserted-by":"publisher","first-page":"8413","DOI":"10.3390\/ijms22168413","article-title":"Neurotoxic effects of neonicotinoids on mammals: what is there beyond the activation of nicotinic acetylcholine receptors? - a systematic review","volume":"22","author":"Costas-Ferreira","year":"2021","journal-title":"Int International Journal of Molecular Sciences"},{"key":"2025030423422540600_ref14","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.3390\/cells11152419","article-title":"A wholistic view of how bumetanide attenuates autism spectrum disorders","volume":"11","author":"Delpire","year":"2022","journal-title":"Cells"},{"key":"2025030423422540600_ref15","doi-asserted-by":"publisher","first-page":"l962","DOI":"10.1136\/bmj.l962","article-title":"Prenatal and infant exposure to ambient pesticides and autism spectrum disorder in children: population based case-control study","volume":"364","author":"Ehrenstein","year":"2019","journal-title":"The BMJ"},{"key":"2025030423422540600_ref16","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.reprotox.2016.04.024","article-title":"Genetic and non-genetic animal models for autism spectrum disorders (ASD)","volume":"64","author":"Ergaz","year":"2016","journal-title":"Reprod Toxicol"},{"key":"2025030423422540600_ref17","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1111\/apa.15723","article-title":"Bumetanide for autism: open-label trial in six children","volume":"110","author":"Fernell","year":"2021","journal-title":"Acta Paediatr"},{"key":"2025030423422540600_ref18","doi-asserted-by":"publisher","first-page":"20400","DOI":"10.1038\/s41598-019-56960-4","article-title":"The chick pallium displays divergent expression patterns of chick orthologues of mammalian neocortical deep layer-specific genes","volume":"9","author":"Fujita","year":"2019","journal-title":"Sci Rep"},{"key":"2025030423422540600_ref19","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3389\/fncel.2017.00359","article-title":"Fundamental elements in autism: from neurogenesis and neurite growth to synaptic plasticity","volume":"11","author":"Gilbert","year":"2017","journal-title":"Front Cell Neurosci"},{"key":"2025030423422540600_ref20","doi-asserted-by":"publisher","first-page":"057002","DOI":"10.1289\/EHP504","article-title":"Prenatal residential proximity to agricultural pesticide use and IQ in 7-year-old children","volume":"125","author":"Gunier","year":"2017","journal-title":"Environ Health Perspect"},{"key":"2025030423422540600_ref21","doi-asserted-by":"publisher","first-page":"3602","DOI":"10.1038\/s41598-018-21958-x","article-title":"Bumetanide for autism: more eye contact, less amygdala activation","volume":"8","author":"Hadjikhani","year":"2018","journal-title":"Sci Rep"},{"key":"2025030423422540600_ref22","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780198521563.001.0001","volume-title":"Memory, imprinting and the brain","author":"Horn","year":"1985"},{"key":"2025030423422540600_ref23","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/s0166-2236(97)01219-8","article-title":"Visual imprinting and the neural mechanisms of recognition memory","volume":"21","author":"Horn","year":"1998","journal-title":"Trends in Neuroscience"},{"key":"2025030423422540600_ref24","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/nrn1324","article-title":"Pathways of the past: the imprint of memory","volume":"5","author":"Horn","year":"2004","journal-title":"Nat Rev Neurosci"},{"key":"2025030423422540600_ref25","doi-asserted-by":"publisher","first-page":"3161","DOI":"10.1523\/JNEUROSCI.05-12-03161.1985","article-title":"Changes in the structure of synapses associated with learning","volume":"5","author":"Horn","year":"1985","journal-title":"J Neurosci"},{"key":"2025030423422540600_ref26","doi-asserted-by":"publisher","first-page":"5282","DOI":"10.1073\/pnas.091094798","article-title":"Tracking memory\u2019s trace","volume":"98","author":"Horn","year":"2001","journal-title":"Proc Natl Acad Sci"},{"key":"2025030423422540600_ref27","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1038\/s41467-017-01749-0","article-title":"GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl\u2212 sensitive WNK1 kinase","volume":"8","author":"Heubl","year":"2017","journal-title":"Nat Commun"},{"key":"2025030423422540600_ref28","doi-asserted-by":"publisher","first-page":"e543","DOI":"10.1212\/NXG.0000000000000543","article-title":"NR4A2 mutations can cause intellectual disability and language impairment with persistent dystonia-parkinsonism","volume":"7","author":"Jes\u00fas","year":"2021","journal-title":"Neurology Genetics"},{"key":"2025030423422540600_ref29","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1111\/1467-8721.ep11509740","article-title":"Imprinting and development of face recognition: from chick to man","volume":"1","author":"Johnson","year":"1992","journal-title":"Curr Dir Psychol Sci"},{"key":"2025030423422540600_ref30","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1038\/nrn1766","article-title":"Subcortical face processing","volume":"6","author":"Johnson","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"2025030423422540600_ref31","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/nrn3819","article-title":"Cation-chloride cotransporters in neuronal development, plasticity and disease","volume":"15","author":"Kaila","year":"2014","journal-title":"Nat Rev Neurosci"},{"key":"2025030423422540600_ref32","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1476-069X-13-3","article-title":"Autism spectrum disorder, flea and tick medication, and adjustments for exposure misclassification: the CHARGE (childhood autism risks from genetics and envinronment) case-control study","volume":"13","author":"Keil","year":"2014","journal-title":"Environ Health"},{"key":"2025030423422540600_ref33","doi-asserted-by":"publisher","first-page":"1404174","DOI":"10.3389\/fnins.2024.1404174","article-title":"Face detection mechanisms: nature vs. nurture","volume":"18","author":"Kobylkov","year":"2024","journal-title":"Front Neurosci"},{"key":"2025030423422540600_ref34","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.1038\/s41380-020-0667-y","article-title":"Nuclear receptor corepressors in intellectual disability and autism","volume":"25","author":"Kong","year":"2020","journal-title":"Mol Psychiatry"},{"key":"2025030423422540600_ref35","volume-title":"A stereotaxic atlas of the brain of the chick (Gallus domesticus)","author":"Kuenzel","year":"1988"},{"key":"2025030423422540600_ref36","doi-asserted-by":"publisher","first-page":"5906","DOI":"10.1093\/cercor\/bhac470","article-title":"Expression patterns of NKCC1 in neurons and non-neuronal cells during cortico-hippocampal development","volume":"33","author":"Kurki","year":"2023","journal-title":"Cereb Cortex"},{"key":"2025030423422540600_ref37","doi-asserted-by":"publisher","first-page":"e202","DOI":"10.1038\/tp.2012.124","article-title":"A randomised controlled trial of bumetanide in the treatment of autism in children","volume":"2","author":"Lemonnier","year":"2012","journal-title":"Transl Psychiatry"},{"key":"2025030423422540600_ref38","doi-asserted-by":"publisher","first-page":"e1056","DOI":"10.1038\/tp.2017.10","article-title":"Effects of bumetanide on neurobehavioral function in children and adolescents with autism spectrum disorders","volume":"7","author":"Lemonnier","year":"2017","journal-title":"Transl Psychiatry"},{"key":"2025030423422540600_ref39","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1111\/cge.13383","article-title":"NR4A2 haploinsufficiency is associated with intellectual disability and autism spectrum disorder","volume":"94","author":"L\u00e9vy","year":"2018","journal-title":"Clin Genet"},{"key":"2025030423422540600_ref40","doi-asserted-by":"publisher","first-page":"29878","DOI":"10.1038\/srep29878","article-title":"The autism-related gene SNRPN regulates cortical and spine development via controlling nuclear receptor Nr4a1","volume":"6","author":"Li","year":"2016","journal-title":"Sci Rep"},{"key":"2025030423422540600_ref41","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s12974-024-03083-x","article-title":"Profiling of long non-coding RNAs in hippocampal\u2013entorhinal system subfields: impact of RN7SL1 on neuroimmune response modulation in Alzheimer\u2019s disease","volume":"21","author":"Liu","year":"2024","journal-title":"J Neuroinflammation"},{"key":"2025030423422540600_ref42","doi-asserted-by":"publisher","first-page":"501","DOI":"10.3389\/fphys.2019.00501","article-title":"Embryonic exposure to valproic acid affects social predispositions for dynamic cues of animate motion in newly-hatched chicks","volume":"10","author":"Lorenzi","year":"2019","journal-title":"Front Physiol"},{"key":"2025030423422540600_ref43","doi-asserted-by":"publisher","first-page":"675994","DOI":"10.3389\/fnbeh.2021.675994","article-title":"Resurgence of an inborn attraction for animate objects via thyroid hormone T3","volume":"15","author":"Lorenzi","year":"2021","journal-title":"Front Behav Neurosci"},{"key":"2025030423422540600_ref44","doi-asserted-by":"publisher","first-page":"108910","DOI":"10.1016\/j.neuropharm.2021.108910","article-title":"CNS pharmacology of NKCC1 inhibitors","volume":"205","author":"L\u00f6scher","year":"2022","journal-title":"Neuropharmacology"},{"key":"2025030423422540600_ref45","doi-asserted-by":"publisher","first-page":"3674","DOI":"10.1111\/ejn.14520","article-title":"Effects of oxytocin-family peptides and substance P on locomotor activity and filial preferences in visually na\u00efve chicks","volume":"50","author":"Loveland","year":"2019","journal-title":"Eur J Neurosci"},{"key":"2025030423422540600_ref46","doi-asserted-by":"publisher","first-page":"285","DOI":"10.5607\/en.2015.24.4.285","article-title":"Exploring the validity of valproic acid animal model of autism","volume":"24","author":"Mabunga","year":"2015","journal-title":"Experimental Neurobiology"},{"key":"2025030423422540600_ref47","doi-asserted-by":"publisher","first-page":"224","DOI":"10.3389\/fnhum.2010.00224","article-title":"The intense world theory \u2013 a unifying theory of the neurobiology of autism","volume":"4","author":"Markram","year":"2010","journal-title":"Front Hum Neurosci"},{"key":"2025030423422540600_ref48","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/0304-3940(95)11255-u","article-title":"Potentiation and depotentiation of DNQX-sensitive fast excitatory synaptic transmission in telencephalone of the quail chick","volume":"185","author":"Matsushima","year":"1995","journal-title":"Neurosci Lett"},{"key":"2025030423422540600_ref49","doi-asserted-by":"publisher","first-page":"tgac041","DOI":"10.1093\/texcom\/tgac041","article-title":"Fetal blockade of nicotinic acetylcholine transmission causes autism-like impairment of biological motion preference in the neonatal chick. Cerebral cortex","volume":"3","author":"Matsushima","year":"2022","journal-title":"Communications"},{"key":"2025030423422540600_ref50","doi-asserted-by":"publisher","first-page":"1279947","DOI":"10.3389\/fnins.2024.1279947","article-title":"The domestic chick as an animal model of autism spectrum disorder: building adaptive social perceptions through prenatally formed predispositions","volume":"18","author":"Matsushima","year":"2024","journal-title":"Front Neurosci"},{"key":"2025030423422540600_ref51","doi-asserted-by":"publisher","first-page":"11417","DOI":"10.1073\/pnas.91.24.11417","article-title":"Learning-related changes in Fos-like immunoreactivity in the chick forebrain after imprinting","volume":"91","author":"McCabe","year":"1994","journal-title":"Proc Natl Acad Sci"},{"key":"2025030423422540600_ref52","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.1001\/jama.2013.4001","article-title":"Risks of in utero exposure to valproate","volume":"309","author":"Meador","year":"2013","journal-title":"JAMA J Am Med Assoc"},{"key":"2025030423422540600_ref53","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1007\/s10071-012-0514-x","article-title":"Preference for biological motion in domestic chicks: sex-dependent effect of early visual experience","volume":"15","author":"Miura","year":"2012","journal-title":"Anim Cogn"},{"key":"2025030423422540600_ref54","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.anbehav.2016.03.025","article-title":"Biological motion facilitates imprinting","volume":"116","author":"Miura","year":"2016","journal-title":"Anim Behav"},{"key":"2025030423422540600_ref55","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.3389\/fphys.2018.01740","article-title":"Thyroid hormone sensitizes the imprinting-associated induction of biological motion preference in domestic chicks","volume":"9","author":"Miura","year":"2018","journal-title":"Front Physiol"},{"key":"2025030423422540600_ref56","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s10071-019-01327-5","article-title":"Combined predisposed preferences for colour and biological motion make robust development of social attachment through imprinting","volume":"23","author":"Miura","year":"2020","journal-title":"Anim Cogn"},{"key":"2025030423422540600_ref57","doi-asserted-by":"publisher","first-page":"fcac221","DOI":"10.1093\/braincomms\/fcac221","article-title":"Impairment in social interaction and hippocampal long-term potentiation at perforant pathway-dentate gyrus synapses in a prenatal valproic acid-induced rat model of autism","volume":"4","author":"Mohammadkhani","year":"2022","journal-title":"Brain Commun"},{"key":"2025030423422540600_ref58","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1136\/jmg.37.7.489","article-title":"A clinical study of 57 children with fetal anticonvulsant syndrome","volume":"37","author":"Moore","year":"2000","journal-title":"J Med Genet"},{"key":"2025030423422540600_ref59","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/j.neuron.2015.07.033","article-title":"Excitatory\/inhibitory balance and circuit homeostasis in autism spectrum disorders","volume":"87","author":"Nelson","year":"2015","journal-title":"Neuron"},{"key":"2025030423422540600_ref60","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.expneurol.2017.04.017","article-title":"The valproic acid-induced rodent model of autism","volume":"299","author":"Nicolini","year":"2018","journal-title":"Exp Neurol"},{"key":"2025030423422540600_ref61","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s00213-013-2979-y","article-title":"Impaired social behavior in chicks exposed to sodium valproate during the last week of embryogenesis","volume":"227","author":"Nishigori","year":"2013","journal-title":"Psychopharmacology"},{"key":"2025030423422540600_ref62","doi-asserted-by":"publisher","first-page":"209646","DOI":"10.1016\/j.envres.2020.109646","article-title":"Pesticides used in Europe and autism spectrum disorder risk: can novel exposure hypotheses be formulated beyond organophosphates, organochlorines, organochlorines, pyrethroids and carbamates? \u2013 a systematic review","volume":"187","author":"Ongono","year":"2020","journal-title":"Environ Res"},{"key":"2025030423422540600_ref63","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1093\/cercor\/bhr156","article-title":"Biological motion processing as a hallmark of social cognition","volume":"22","author":"Pavlova","year":"2012","journal-title":"Cereb Cortex"},{"key":"2025030423422540600_ref64","doi-asserted-by":"publisher","first-page":"2734","DOI":"10.1038\/s41598-017-02790-1","article-title":"Social cognition in autism: face tuning","volume":"7","author":"Pavlova","year":"2017","journal-title":"Sci Rep"},{"key":"2025030423422540600_ref65","doi-asserted-by":"publisher","first-page":"36734","DOI":"10.1074\/jbc.M101287200","article-title":"Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen","volume":"276","author":"Phiel","year":"2001","journal-title":"J Biol Chem"},{"key":"2025030423422540600_ref66","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1017\/S0012162205001076","article-title":"Characteristics of fetal anticonvulsant syndrome associated autistic disorder","volume":"47","author":"Rasalam","year":"2005","journal-title":"Developmental Medicine & Child Neurology"},{"key":"2025030423422540600_ref67","doi-asserted-by":"publisher","first-page":"13501","DOI":"10.1073\/pnas.0704391104","article-title":"Elevated NMDA receptor levels and enhanced post-synaptic long-term potentiation induced by prenatal exposure to valproic acid","volume":"104","author":"Rinaldi","year":"2007","journal-title":"Proc Natl Acad Sci"},{"key":"2025030423422540600_ref68","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1111\/j.1467-7687.2009.00914.x","article-title":"Faces are special for newly hatched chicks: evidence for inborn domain-specific mechanisms underlying spontaneous preferences for face-like stimuli","volume":"13","author":"Rosa-Salva","year":"2010","journal-title":"Dev Sci"},{"key":"2025030423422540600_ref69","doi-asserted-by":"publisher","first-page":"e18802","DOI":"10.1371\/journal.pone.0018802","article-title":"The evolution of social orienting: evidence from chicks (Gallus gallus) and human newborns","volume":"6","author":"Rosa-Salva","year":"2011","journal-title":"PLoS One"},{"key":"2025030423422540600_ref70","doi-asserted-by":"publisher","first-page":"e0222079","DOI":"10.1371\/journal.Pone.0222079","article-title":"Unlearned visual preferences for the head region in domestic chicks","volume":"14","author":"Rosa-Salva","year":"2019","journal-title":"PLoS One"},{"key":"2025030423422540600_ref71","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1034\/j.1601-183X.2003.00037.x","article-title":"Model of autism: increased ratio of excitation\/inhibition in key neural systems","volume":"2","author":"Rubenstein","year":"2003","journal-title":"Genes Brain Behav"},{"key":"2025030423422540600_ref72","doi-asserted-by":"publisher","first-page":"881947","DOI":"10.3389\/fphys.2022.881947","article-title":"Suppressive modulation of the chick forebrain network for imprinting by thyroid hormone: an in vitro study","volume":"13","author":"Saheki","year":"2022","journal-title":"Front Physiol"},{"key":"2025030423422540600_ref73","doi-asserted-by":"publisher","first-page":"228","DOI":"10.3389\/fnins.2016.00228","article-title":"In utero and lactational exposure to acetamiprid induces abnormalities in socio-sexual and anxiety-related behaviors of male mice","volume":"10","author":"Sano","year":"2016","journal-title":"Front Neurosci"},{"key":"2025030423422540600_ref74","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/j.tips.2021.09.005","article-title":"Pharmacological tools to target NKCC1 in brain disorders","volume":"42","author":"Savardi","year":"2021","journal-title":"Trends Pharmacol Sci"},{"key":"2025030423422540600_ref75","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/BF02408436","article-title":"Toward objective classification of childhood autism: childhood autism rating scale (CARS)","volume":"10","author":"Schopler","year":"1980","journal-title":"J Autism Dev Disord"},{"key":"2025030423422540600_ref76","doi-asserted-by":"publisher","first-page":"5919","DOI":"10.1038\/s41598-018-24202-8","article-title":"Embryonic exposure to valproic acid impairs social predispositions of newly-hatched chicks","volume":"8","author":"Sgad\u00f2","year":"2018","journal-title":"Scientific Report"},{"key":"2025030423422540600_ref77","doi-asserted-by":"publisher","first-page":"1462272","DOI":"10.3389\/fnins.2024.1462272","article-title":"Face processing in animal models: implications for autism spectrum disorder","volume":"18","author":"Sgad\u00f2","year":"2024","journal-title":"Front Neurosci"},{"key":"2025030423422540600_ref78","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1073\/pnas.0707021105","article-title":"A predisposition for biological motion in the newborn baby","volume":"105","author":"Simion","year":"2008","journal-title":"Proc Natl Acad Sci"},{"key":"2025030423422540600_ref79","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1038\/s41436-020-0815-4","article-title":"De novo variants of NR4A2 are associated with neurodevelopmental disorder and epilepsy","volume":"22","author":"Singh","year":"2020","journal-title":"Genetics in Medicine"},{"key":"2025030423422540600_ref80","doi-asserted-by":"publisher","first-page":"e48648","DOI":"10.7554\/eLife.48648","article-title":"The NKCC1 antagonist bumetanide mitigates interneuronopathy associated with ethanol exposure in utero","volume":"8","author":"Skorput","year":"2019","journal-title":"elife"},{"key":"2025030423422540600_ref81","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1046\/j.1460-9568.2003.02539.x","article-title":"Analysis of differential gene expression supports a role for amyloid precursor protein and a protein kinase C substrate (MARCKS) in long-term memory","volume":"17","author":"Solomonia","year":"2003","journal-title":"Eur J Neurosci"},{"key":"2025030423422540600_ref82","doi-asserted-by":"publisher","first-page":"956429","DOI":"10.3389\/fnins.2022.956429","article-title":"Two novel heterozygous truncating variants in NR4A2 identified in patients with neurodevelopmental disorder and brief literature review","volume":"16","author":"Song","year":"2022","journal-title":"Front Neurosci"},{"key":"2025030423422540600_ref83","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/j.jaac.2020.07.888","article-title":"Bumetanide for core symptoms of autism spectrum disorder (BAMBI): a single center, double-blinded, participant-randomized, placebo-controlled, phase-2 superiority trial","volume":"60","author":"Sprengers","year":"2021","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"2025030423422540600_ref84","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.bbr.2018.04.039","article-title":"Gene expression of Dio2 (thyroid hormone converting enzyme) in telencephalon is linked with predisposed biological motion preference in domestic chicks","volume":"349","author":"Takemura","year":"2018","journal-title":"Behav Brain Res"},{"key":"2025030423422540600_ref85","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1038\/s43587-021-00122-7","article-title":"Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer\u2019s disease","volume":"1","author":"Taubes","year":"2021","journal-title":"Nature Aging"},{"key":"2025030423422540600_ref86","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1126\/science.1133212","article-title":"Maternal oxytocin triggers a transient inhibitory switch in GABA signaling in the fetal brain during delivery","volume":"314","author":"Tyzio","year":"2006","journal-title":"Science"},{"key":"2025030423422540600_ref87","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1126\/science.1247190","article-title":"Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring","volume":"343","author":"Tyzio","year":"2014","journal-title":"Science"},{"key":"2025030423422540600_ref88","doi-asserted-by":"publisher","first-page":"e208","DOI":"10.1371\/journal.pbio.0030208","article-title":"Visually inexperienced chicks exhibit spontaneous preference for biological motion patterns","volume":"3","author":"Vallortigara","year":"2005","journal-title":"PLoS Biol"},{"key":"2025030423422540600_ref3","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1007\/s10803-022-05841-3","article-title":"Effects of bumetanide on neurocognitive functioning in children with autism spectrum disorder: secondary analysis of a randomized placebo-controlled trial","volume":"54","author":"Andel","year":"2023","journal-title":"J Autism Dev Disord"},{"key":"2025030423422540600_ref89","doi-asserted-by":"publisher","first-page":"751575","DOI":"10.3389\/fpsyt.2021.751575","article-title":"Treatment effect of bumetanide in children with autism spectrum disorder: a systematic review and meta-analysis","volume":"12","author":"Wang","year":"2021","journal-title":"Frontiers in Psychiatry"},{"key":"2025030423422540600_ref90","doi-asserted-by":"publisher","first-page":"371","DOI":"10.3389\/fncel.2015.00371","article-title":"Development and regulation of chloride homeostasis in the central nervous system","volume":"9","author":"Watanabe","year":"2015","journal-title":"Front Cell Neurosci"},{"key":"2025030423422540600_ref91","doi-asserted-by":"publisher","first-page":"102363","DOI":"10.1016\/j.rasd.2024.102363","article-title":"Can bumetanide be a miraculous medicine for autism spectrum disorder: meta-analysis evidence from randomized controlled trials","volume":"114","author":"Xiao","year":"2024","journal-title":"Res Autism Spectr Disord"},{"key":"2025030423422540600_ref92","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1038\/ncomms2088","article-title":"Thyroid hormone determines the start of the sensitive period of imprinting and primes later learning","volume":"3","author":"Yamaguchi","year":"2012","journal-title":"Nat Commun"},{"key":"2025030423422540600_ref93","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/s0006-8993(97)01129-3","article-title":"Distinct mechanisms for expression of Fos-like immunoreactivity and synaptic potentiation in telencephalic hyperstriatum of the quail chick","volume":"779","author":"Yanagihara","year":"1998","journal-title":"Brain Res"},{"key":"2025030423422540600_ref94","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0304-3940(03)00982-0","article-title":"The influence of developmental periods of sodium valproate exposure on synaptic plasticity in the CA1 region of rat hippocampus","volume":"351","author":"Zhang","year":"2003","journal-title":"Neurosci Lett"},{"key":"2025030423422540600_ref95","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/s41398-018-0267-7","article-title":"Global long non-coding RNA expression in the rostral anterior cingulate cortex of depressed suicides","volume":"8","author":"Zhou","year":"2018","journal-title":"Transl Psychiatry"}],"container-title":["Cerebral Cortex"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cercor\/article-pdf\/35\/2\/bhaf044\/62239355\/bhaf044.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cercor\/article-pdf\/35\/2\/bhaf044\/62239355\/bhaf044.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T23:42:32Z","timestamp":1741131752000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cercor\/article\/doi\/10.1093\/cercor\/bhaf044\/8050769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":95,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2,5]]}},"URL":"https:\/\/doi.org\/10.1093\/cercor\/bhaf044","relation":{},"ISSN":["1047-3211","1460-2199"],"issn-type":[{"value":"1047-3211","type":"print"},{"value":"1460-2199","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,2]]},"published":{"date-parts":[[2025,2]]},"article-number":"bhaf044"}}