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Despite its application, the genetic underpinnings of FOCA alterations in Alzheimer\u2019s Disease (AD)-related Mild Cognitive Impairment (MCI) remain largely unexplored. To elucidate these changes, we analyzed group FOCA differences in 41 MCI patients and 46 controls from the Alzheimer\u2019s Disease Neuroimaging Initiative database. Integrating the Allen Human Brain Atlas, we performed transcriptome-neuroimaging spatial association analyses to pinpoint genes correlating with MCI-related FOCA changes. We observed heightened FOCA in the frontal\u2013parietal system and diminished FOCA in the temporal lobe and medium cingulate gyrus among MCI patients. These FOCA alterations were spatially linked to the expression of 384 genes, which were enriched in crucial molecular functions, biological processes, and cellular components of the cerebral cortex, as well as related pathways. These genes were specifically expressed in brain tissue and corticothalamic neurons, particularly during late cortical development. They also connected to various behavioral domains. Furthermore, these genes could form a protein\u2013protein interaction network, supported by 34 hub genes. Our results suggest that local spatiotemporal consistency of spontaneous brain activity in MCI may stem from the complex interplay of a broad spectrum of genes with diverse functional features.<\/jats:p>","DOI":"10.1093\/cercor\/bhaf045","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T23:18:36Z","timestamp":1741130316000},"source":"Crossref","is-referenced-by-count":2,"title":["Altered spatiotemporal consistency and their genetic mechanisms in mild cognitive impairment: a combined neuroimaging and transcriptome study"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9426-088X","authenticated-orcid":false,"given":"Yao","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Neurology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China , No. 17 Lujiang Road, Luyang 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Sciences and Medicine, University of Science and Technology of China , No. 17 Lujiang Road, Luyang District, Hefei, Anhui 230001 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China , No. 17 Lujiang Road, Luyang District, Hefei, Anhui 230001 ,","place":["China"]},{"name":"Department of Electronic Engineering and Information Science, School of Information Science and Technology, University of Science and Technology of China , No. 443, Huangshan Road, Shushan District, Hefei, Anhui 230022 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, 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