{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:06:52Z","timestamp":1789769212184,"version":"4.0.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People\u2019s Republic of China","doi-asserted-by":"publisher","award":["2022ZD0205200"],"award-info":[{"award-number":["2022ZD0205200"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People\u2019s Republic of China","doi-asserted-by":"publisher","award":["2022ZD0211700"],"award-info":[{"award-number":["2022ZD0211700"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2025ZNSFSC0783"],"award-info":[{"award-number":["2025ZNSFSC0783"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Sleep disturbances are prevalent in bipolar disorder (BD) patients, and the circadian locomotor output cycles kaput (Clock) gene plays a significant role in this process. The role of microglia (the brain-resident immune cells) in mediating this process remains uncertain. In this study, our findings showed that sleep loss induces mania-like behavior, microglial loss, and time-dependent gene expression changes. Moreover, diurnal oscillations in circadian rhythm-associated and inflammation-related gene expression in the mouse prefrontal cortex (PFC) were altered following sleep deprivation (SD). Further correlative analysis revealed correlations in gene expression between marker genes for microglia and Clock genes. In addition, the Clock mutation induces mania-like behavior, inhibition of neural activity, and microglial loss. Transcriptomic analysis revealed significant alterations in inflammatory pathways, circadian rhythm-related pathways, and the major histocompatibility protein complex in Clock\u039419 mice. Subsequent correlative analysis demonstrated significant correlations in gene expression among inflammation-, circadian rhythm-, and synapse-related genes within the PFC and hypothalamus of both male and female Clock\u039419 mice. In conclusion, our findings demonstrated behavioral, cellular, and molecular changes in SD-induced mice and Clock-mutant mice models. Microglia and CLOCK were associated with mania-like behaviors. Future research will likely focus on microglia-targeted approaches for the diagnosis and treatment of BD.<\/jats:p>","DOI":"10.1093\/cercor\/bhaf090","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T12:05:05Z","timestamp":1748347505000},"source":"Crossref","is-referenced-by-count":5,"title":["Behavioral, cellular, and molecular changes in two animal models of bipolar disorder mania: sleep deprivation-induced mice and <i>Clock<\/i>-mutant mice"],"prefix":"10.1093","volume":"35","author":[{"given":"Rong-Jun","family":"Ni","sequence":"first","affiliation":[{"name":"Mental Health Center and Institute of Psychiatry, West China Hospital, Sichuan University , No. 28 Dianxin South Street, Wuhou District, Chengdu, Sichuan 610041 ,","place":["China"]},{"name":"Sichuan Clinical Medical Research Center for Mental Disorders, West China Hospital, Sichuan University , No. 28 Dianxin South Street, Wuhou District, Chengdu, Sichuan 610044 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Mental Health Center and Institute of Psychiatry, West China Hospital, Sichuan University , No. 28 Dianxin South Street, Wuhou District, Chengdu, Sichuan 610041 ,","place":["China"]},{"name":"Sichuan Clinical Medical Research Center for Mental Disorders, West China Hospital, Sichuan University , No. 28 Dianxin South Street, Wuhou District, Chengdu, Sichuan 610044 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Mian","family":"Shu","sequence":"additional","affiliation":[{"name":"School of Architecture and Civil Engineering, Chengdu University , No. 2025 Chengluo Avenue, Chengdu 610106 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Ying","family":"Wei","sequence":"additional","affiliation":[{"name":"Mental Health Center and Institute of Psychiatry, West China Hospital, Sichuan University , No. 28 Dianxin South Street, Wuhou District, Chengdu, Sichuan 610041 ,","place":["China"]},{"name":"Sichuan Clinical Medical Research Center for Mental Disorders, West China Hospital, Sichuan University , No. 28 Dianxin South Street, Wuhou District, Chengdu, Sichuan 610044 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Xue","family":"Wei","sequence":"additional","affiliation":[{"name":"Mental Health Center and Institute of Psychiatry, West China Hospital, Sichuan University , No. 28 Dianxin South Street, Wuhou District, Chengdu, Sichuan 610041 ,","place":["China"]},{"name":"Sichuan Clinical Medical Research Center for Mental Disorders, West China Hospital, Sichuan University , No. 28 Dianxin South Street, Wuhou District, Chengdu, Sichuan 610044 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian-Sheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Mental Health Center and Institute of Psychiatry, West China Hospital, Sichuan University , No. 28 Dianxin South Street, Wuhou District, Chengdu, Sichuan 610041 ,","place":["China"]},{"name":"Sichuan Clinical Medical Research Center for Mental Disorders, West China Hospital, Sichuan University , No. 28 Dianxin South Street, Wuhou District, Chengdu, Sichuan 610044 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Hong","family":"Ma","sequence":"additional","affiliation":[{"name":"Mental Health Center and Institute of Psychiatry, West China Hospital, Sichuan University , No. 28 Dianxin South Street, Wuhou District, Chengdu, Sichuan 610041 ,","place":["China"]},{"name":"Sichuan Clinical Medical Research Center for Mental Disorders, West China Hospital, Sichuan University , No. 28 Dianxin South Street, Wuhou District, Chengdu, Sichuan 610044 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"2025052708045965800_ref1","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1038\/s41598-021-04079-w","article-title":"Cortical diurnal rhythms remain intact with microglial depletion","volume":"12","author":"Barahona","year":"2022","journal-title":"Sci Rep"},{"key":"2025052708045965800_ref2","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1111\/jnc.16098","article-title":"The emerging neuroimmune hypothesis of bipolar disorder: an updated overview of neuroimmune and microglial findings","volume":"168","author":"Chaves-Filho","year":"2024","journal-title":"J Neurochem"},{"key":"2025052708045965800_ref3","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1158\/2159-8290.CD-19-0400","article-title":"Circadian regulator CLOCK recruits immune-suppressive microglia into the GBM tumor microenvironment","volume":"10","author":"Chen","year":"2020","journal-title":"Cancer Discov"},{"key":"2025052708045965800_ref4","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1016\/j.cell.2014.03.039","article-title":"Impact of circadian nuclear receptor REV-ERB\u03b1 on midbrain dopamine production and mood regulation","volume":"157","author":"Chung","year":"2014","journal-title":"Cell"},{"key":"2025052708045965800_ref5","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1038\/npp.2011.33","article-title":"Specific role of VTA dopamine neuronal firing rates and morphology in the reversal of anxiety-related, but not depression-related behavior in the Clock\u039419 mouse model of mania","volume":"36","author":"Coque","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"2025052708045965800_ref6","doi-asserted-by":"publisher","first-page":"110691","DOI":"10.1016\/j.pnpbp.2022.110691","article-title":"Gene expression of circadian genes and CIART in bipolar disorder: a preliminary case-control study","volume":"122","author":"Courtin","year":"2023","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"2025052708045965800_ref7","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jpsychires.2019.09.003","article-title":"Effects of lithium and valproate on behavioral parameters and neurotrophic factor levels in an animal model of mania induced by paradoxical sleep deprivation","volume":"119","author":"Dal-Pont","year":"2019","journal-title":"J Psychiatr Res"},{"key":"2025052708045965800_ref8","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.bbi.2022.09.014","article-title":"Early life stress impairs synaptic pruning in the developing hippocampus","volume":"107","author":"Dayananda","year":"2023","journal-title":"Brain Behav Immun"},{"key":"2025052708045965800_ref9","doi-asserted-by":"publisher","first-page":"3117","DOI":"10.1038\/s41380-024-02569-7","article-title":"Cell-type and sex-specific rhythmic gene expression in the nucleus accumbens","volume":"29","author":"DePoy","year":"2024","journal-title":"Mol Psychiatry"},{"key":"2025052708045965800_ref10","doi-asserted-by":"publisher","first-page":"16314","DOI":"10.1523\/JNEUROSCI.4289-10.2010","article-title":"Lithium ameliorates nucleus accumbens phase-signaling dysfunction in a genetic mouse model of mania","volume":"30","author":"Dzirasa","year":"2010","journal-title":"J Neurosci"},{"key":"2025052708045965800_ref11","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.neuron.2014.02.040","article-title":"Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain","volume":"82","author":"Elmore","year":"2014","journal-title":"Neuron"},{"key":"2025052708045965800_ref12","doi-asserted-by":"publisher","first-page":"e745","DOI":"10.1038\/tp.2016.19","article-title":"Distinct effects of folate pathway genes MTHFR and MTHFD1L on ruminative response style: a potential risk mechanism for depression","volume":"6","author":"Eszlari","year":"2016","journal-title":"Transl Psychiatry"},{"key":"2025052708045965800_ref13","doi-asserted-by":"publisher","first-page":"2906","DOI":"10.1210\/en.2016-1911","article-title":"Deoxycorticosterone\/salt-mediated cardiac inflammation and fibrosis are dependent on functional CLOCK signaling in male mice","volume":"158","author":"Fletcher","year":"2017","journal-title":"Endocrinology"},{"key":"2025052708045965800_ref14","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.bbi.2014.11.009","article-title":"Microglia inflammatory responses are controlled by an intrinsic circadian clock","volume":"45","author":"Fonken","year":"2015","journal-title":"Brain Behav Immun"},{"key":"2025052708045965800_ref15","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/s41398-019-0671-7","article-title":"Longitudinal transcriptome-wide gene expression analysis of sleep deprivation treatment shows involvement of circadian genes and immune pathways","volume":"9","author":"Foo","year":"2019","journal-title":"Transl Psychiatry"},{"key":"2025052708045965800_ref16","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.sleep.2022.07.006","article-title":"On-call-related sleep deprivation and hypomania in healthcare workers","volume":"99","author":"G\u00f3mez-Dur\u00e1n","year":"2022","journal-title":"Sleep Med"},{"key":"2025052708045965800_ref17","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1186\/s12974-018-1283-5","article-title":"ITGB4 deficiency in bronchial epithelial cells directs airway inflammation and bipolar disorder-related behavior","volume":"15","author":"Han","year":"2018","journal-title":"J Neuroinflammation"},{"key":"2025052708045965800_ref18","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1176\/appi.ajp.2008.08010098","article-title":"Sleep and circadian rhythms in bipolar disorder: seeking synchrony, harmony, and regulation","volume":"165","author":"Harvey","year":"2008","journal-title":"Am J Psychiatry"},{"key":"2025052708045965800_ref19","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12974-023-02727-8","article-title":"Myeloid deficiency of the intrinsic clock protein BMAL1 accelerates cognitive aging by disrupting microglial synaptic pruning","volume":"20","author":"Iweka","year":"2023","journal-title":"J Neuroinflammation"},{"key":"2025052708045965800_ref20","doi-asserted-by":"publisher","first-page":"3633","DOI":"10.1182\/blood-2009-03-208843","article-title":"Colony-stimulating factor-1-induced oscillations in phosphatidylinositol-3 kinase\/AKT are required for caspase activation in monocytes undergoing differentiation into macrophages","volume":"114","author":"Jacquel","year":"2009","journal-title":"Blood"},{"key":"2025052708045965800_ref21","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.freeradbiomed.2016.07.027","article-title":"Quercetin reduces manic-like behavior and brain oxidative stress induced by paradoxical sleep deprivation in mice","volume":"99","author":"Kanazawa","year":"2016","journal-title":"Free Radic Biol Med"},{"key":"2025052708045965800_ref22","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.bbi.2021.11.020","article-title":"Inflammatory markers, brain-derived neurotrophic factor, and the symptomatic course of adolescent bipolar disorder: a prospective repeated-measures study","volume":"100","author":"Karthikeyan","year":"2022","journal-title":"Brain Behav Immun"},{"key":"2025052708045965800_ref23","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/mp.2017.192","article-title":"Face and predictive validity of the Clock\u039419 mouse as an animal model for bipolar disorder: a systematic review","volume":"23","author":"Kristensen","year":"2018","journal-title":"Mol Psychiatry"},{"key":"2025052708045965800_ref24","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.bbi.2021.12.006","article-title":"TNF signaling pathway-mediated microglial activation in the PFC underlies acute paradoxical sleep deprivation-induced anxiety-like behaviors in mice","volume":"100","author":"Liu","year":"2022","journal-title":"Brain Behav Immun"},{"key":"2025052708045965800_ref25","doi-asserted-by":"publisher","first-page":"4066","DOI":"10.1038\/s41380-020-00958-2","article-title":"Valproate reverses mania-like behaviors in mice via preferential targeting of HDAC2","volume":"26","author":"Logan","year":"2021","journal-title":"Mol Psychiatry"},{"key":"2025052708045965800_ref26","doi-asserted-by":"publisher","first-page":"S683","DOI":"10.1016\/j.euroneuro.2011.07.008","article-title":"Circadian rhythms and mood regulation: insights from pre-clinical models","volume":"21","author":"McClung","year":"2011","journal-title":"Eur Neuropsychopharmacol"},{"key":"2025052708045965800_ref27","doi-asserted-by":"publisher","first-page":"104905","DOI":"10.1016\/j.neuint.2020.104905","article-title":"Microglial circadian clock regulation of microglial structural complexity, dendritic spine density and inflammatory response","volume":"142","author":"Nakanishi","year":"2021","journal-title":"Neurochem Int"},{"key":"2025052708045965800_ref28","doi-asserted-by":"publisher","first-page":"989","DOI":"10.24272\/j.issn.2095-8137.2022.278","article-title":"Chronic lithium treatment ameliorates ketamine-induced mania-like behavior via the PI3K-AKT signaling pathway","volume":"43","author":"Ni","year":"2022","journal-title":"Zool Res"},{"key":"2025052708045965800_ref29","doi-asserted-by":"publisher","first-page":"543","DOI":"10.24272\/j.issn.2095-8137.2022.389","article-title":"Depletion of microglia with PLX3397 attenuates MK-801-induced hyperactivity associated with regulating inflammation-related genes in the brain","volume":"44","author":"Ni","year":"2023","journal-title":"Zool Res"},{"key":"2025052708045965800_ref30","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.bbi.2023.12.031","article-title":"Differential effects of sleep deprivation on behavior and microglia in a brain-region-specific manner in young and aged male mice","volume":"117","author":"Ni","year":"2024","journal-title":"Brain Behav Immun"},{"key":"2025052708045965800_ref31","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"2025052708045965800_ref32","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.bbi.2022.09.016","article-title":"Microglial homeostasis disruption modulates non-rapid eye movement sleep duration and neuronal activity in adult female mice","volume":"107","author":"Picard","year":"2023","journal-title":"Brain Behav Immun"},{"key":"2025052708045965800_ref33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neubiorev.2021.09.023","article-title":"The emerging tale of microglia in psychiatric disorders","volume":"131","author":"Rahimian","year":"2021","journal-title":"Neurosci Biobehav Rev"},{"key":"2025052708045965800_ref34","doi-asserted-by":"publisher","first-page":"6406","DOI":"10.1073\/pnas.0609625104","article-title":"Mania-like behavior induced by disruption of CLOCK","volume":"104","author":"Roybal","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025052708045965800_ref35","doi-asserted-by":"publisher","first-page":"5500","DOI":"10.1016\/j.cell.2023.10.025","article-title":"Prolonged sleep deprivation induces a cytokine-storm-like syndrome in mammals","volume":"186","author":"Sang","year":"2023","journal-title":"Cell"},{"key":"2025052708045965800_ref36","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/sj.npp.1301575","article-title":"Cellular plasticity cascades in the pathophysiology and treatment of bipolar disorder","volume":"33","author":"Schloesser","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"2025052708045965800_ref37","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"2025052708045965800_ref38","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1111\/acer.12834","article-title":"Chronic alcohol exposure and the circadian clock mutation exert tissue-specific effects on gene expression in mouse hippocampus, liver, and proximal colon","volume":"39","author":"Summa","year":"2015","journal-title":"Alcohol Clin Exp Res"},{"key":"2025052708045965800_ref39","doi-asserted-by":"publisher","first-page":"D447","DOI":"10.1093\/nar\/gku1003","article-title":"STRING v10: protein\u2013protein interaction networks, integrated over the tree of life","volume":"43","author":"Szklarczyk","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2025052708045965800_ref40","doi-asserted-by":"publisher","first-page":"eaax1215","DOI":"10.1126\/sciimmunol.aax1215","article-title":"A circadian clock is essential for homeostasis of group 3 innate lymphoid cells in the gut","volume":"4","author":"Teng","year":"2019","journal-title":"Sci Immunol"},{"key":"2025052708045965800_ref41","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1016\/j.cell.2020.04.049","article-title":"Sleep loss can cause death through accumulation of reactive oxygen species in the gut","volume":"181","author":"Vaccaro","year":"2020","journal-title":"Cell"},{"key":"2025052708045965800_ref42","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.bbi.2024.07.027","article-title":"Sleep\u2013wake behavior and responses to sleep deprivation and immune challenge of protein kinase RNA-activated knockout mice","volume":"121","author":"Valencia-Sanchez","year":"2024","journal-title":"Brain Behav Immun"},{"key":"2025052708045965800_ref43","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/S2215-0366(15)00156-X","article-title":"An evidence map of psychosocial interventions for the earliest stages of bipolar disorder","volume":"2","author":"Vallarino","year":"2015","journal-title":"Lancet Psychiatry"},{"key":"2025052708045965800_ref44","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1111\/ejn.14922","article-title":"Role of epigenetic regulatory enzymes in animal models of mania induced by amphetamine and paradoxical sleep deprivation","volume":"53","author":"Varela","year":"2021","journal-title":"Eur J Neurosci"},{"key":"2025052708045965800_ref45","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1111\/joa.13874","article-title":"Dynamic changes in microglia in the mouse hippocampus during administration and withdrawal of the CSF1R inhibitor PLX3397","volume":"243","author":"Wang","year":"2023","journal-title":"J Anat"},{"key":"2025052708045965800_ref46","doi-asserted-by":"publisher","first-page":"2763","DOI":"10.3390\/ijms18122763","article-title":"A genome-wide association study and complex network identify four core hub genes in bipolar disorder","volume":"18","author":"Xie","year":"2017","journal-title":"Int J Mol Sci"},{"key":"2025052708045965800_ref47","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/mp.2008.10","article-title":"Assessment of circadian function in fibroblasts of patients with bipolar disorder","volume":"14","author":"Yang","year":"2009","journal-title":"Mol Psychiatry"},{"key":"2025052708045965800_ref48","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/s41593-022-01024-6","article-title":"Amygdala and anterior cingulate transcriptomes from individuals with bipolar disorder reveal downregulated neuroimmune and synaptic pathways","volume":"25","author":"Zandi","year":"2022","journal-title":"Nat Neurosci"},{"key":"2025052708045965800_ref49","doi-asserted-by":"publisher","first-page":"e3000134","DOI":"10.1371\/journal.pbio.3000134","article-title":"Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain","volume":"17","author":"Zhan","year":"2019","journal-title":"PLoS Biol"}],"container-title":["Cerebral Cortex"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cercor\/article-pdf\/35\/5\/bhaf090\/63371019\/bhaf090.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cercor\/article-pdf\/35\/5\/bhaf090\/63371019\/bhaf090.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T12:05:06Z","timestamp":1748347506000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cercor\/article\/doi\/10.1093\/cercor\/bhaf090\/8151406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,1]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cercor\/bhaf090","relation":{},"ISSN":["1047-3211","1460-2199"],"issn-type":[{"value":"1047-3211","type":"print"},{"value":"1460-2199","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,5]]},"published":{"date-parts":[[2025,5,1]]},"article-number":"bhaf090"}}