{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:47:14Z","timestamp":1792176434587,"version":"4.4.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Science and Technology Innovation 2030","award":["2021ZD0201800"],"award-info":[{"award-number":["2021ZD0201800"]}]},{"name":"Clinical Medicine Outstanding Talent Cultivation Project","award":["ZF2025067"],"award-info":[{"award-number":["ZF2025067"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cortical excitability, the tendency of neurons to respond to various stimuli, is impaired in most neuropsychiatric conditions. Non-invasive brain stimulation can exert therapeutic effects by modulating the cortical excitability. Transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) have shown promise in various neuropsychiatric disorders, including improving cognitive abilities and motor function following stroke. Oscillatory transcranial direct current stimulation (otDCS), as a novel stimulation paradigm, combines tDCS and tACS to simultaneously regulate neuronal membrane potentials and oscillatory rhythms. This combination may produce more significant effects on neurons. To investigate this, participants received the following stimuli for 20\u00a0min on different days: (i) 2\u00a0mA 40\u00a0Hz otDCS, (ii) 2\u00a0mA 40\u00a0Hz tACS, (iii) 2\u00a0mA tDCS, and (iv) sham stimulation. Motor evoked potentials (MEPs) and transcranial magnetic stimulation combined with electroencephalography (TMS-EEG) were assessed both before and after stimulation. The increase in MEPs amplitudes was most pronounced under otDCS conditions compared with tACS and tDCS. Furthermore, analysis of TMS-EEG data revealed that changes in time-varying brain network patterns were most pronounced after otDCS, manifesting as enhanced brain-wide information connectivity. Our results indicate that gamma otDCS has significant potential for regulating cortical excitability and activating brain networks.<\/jats:p>","DOI":"10.1093\/cercor\/bhaf093","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T12:12:08Z","timestamp":1745928728000},"source":"Crossref","is-referenced-by-count":4,"title":["Gamma oscillatory transcranial direct current stimulation of motor cortex enhances corticospinal excitability and brain connectivity in healthy individuals"],"prefix":"10.1093","volume":"35","author":[{"given":"Ziyu","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Hospital of Hebei Medical University , No. 89 Donggang Road, Yuhua District, Shijiazhuang 050031 ,","place":["China"]},{"name":"Department of Neurology of Graduate School, Hebei Medical University , No. 361 Zhongshan Street, Changan District, Shijiazhuang 050017 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Hebei Province , No. 89 Donggang Road, Yuhua District, Shijiazhuang 050031 ,","place":["China"]},{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University , No. 45 Changchun Street, Xicheng District, Beijing 100053 ,","place":["China"]},{"name":"Beijing Key Laboratory of Neuromodulation , No. 45 Changchun Street, Xicheng District, Beijing 100053 ,","place":["China"]},{"name":"Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University , No.10 Xitoutiao, You An Men Wai, Fengtai District, Beijing 100069 ,","place":["China"]},{"name":"Center for Sleep and Consciousness Disorders, Beijing Institute for Brain Disorders , No. 45 Changchun Street, Xicheng District, Beijing 100053 ,","place":["China"]},{"name":"Collaborative Innovation Center for Brain Disorders, Capital Medical University , No. 45 Changchun Street, Xicheng District, Beijing 100053 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