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In this study, we investigated whether structural and functional connectivity between and within the attention networks, thalamus, and early visual areas is differentially associated with performance on a conjunction search task in participants with CVI as compared to controls. Data from 26 participants was collected and analyzed (10 CVI, four female, 17.4\u00a0years, 5.38\u00a0s.d., 16 control, 10 female, 22.25\u00a0years, 4.25\u00a0s.d.). White matter tracts associated with the dorsal and ventral attention networks as well as structural and functional connectivity matrices of the dorsal and ventral attention networks were generated for each participant. Group differences in conjunction search outcomes, tract volume, and network connectivity strength were evaluated. General linear models were used to investigate the relationship between neuroimaging predictor variables and each of the four conjunction search primary outcomes. All analyses were adjusted for age and verbal cognition. In the CVI group impaired visual search was associated with weaker structural and stronger functional connectivity, while in the control group the opposite effect was observed. Together, these results suggest that functional over-recruitment may be a maladaptive compensatory mechanism.<\/jats:p>","DOI":"10.1093\/cercor\/bhaf173","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T05:53:11Z","timestamp":1751608391000},"source":"Crossref","is-referenced-by-count":2,"title":["Structural and functional attention network connectivity in relation to visual selective attention dysfunction in cerebral visual impairment"],"prefix":"10.1093","volume":"35","author":[{"given":"Marie","family":"Drottar","sequence":"first","affiliation":[{"name":"Laboratory of Neuroimaging and Vision Science, Department of Radiology , , 125 Nashua Street, Boston, MA 02114 ,","place":["United States"]},{"name":"Massachusetts General Hospital , , 125 Nashua Street, Boston, MA 02114 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire E","family":"Manley","sequence":"additional","affiliation":[{"name":"Laboratory of Visual Neuroplasticity, Department of Ophthalmology , , 20 Staniford Street, Boston, MA 02114 ,","place":["United States"]},{"name":"Massachusetts Eye and Ear , , 20 Staniford Street, Boston, MA 02114 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negin","family":"Nadvar","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroimaging and Vision Science, Department of Radiology , , 125 Nashua Street, Boston, MA 02114 ,","place":["United States"]},{"name":"Massachusetts General Hospital , , 125 Nashua Street, Boston, MA 02114 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard J","family":"Cabral","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Boston University School of Public Health , 801 Massachusetts Avenue, Boston, MA 02118 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J","family":"Bex","sequence":"additional","affiliation":[{"name":"Department of Psychology, Northeastern University , 125 Nightingale Hall, Boston, MA 02115 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8094-9536","authenticated-orcid":false,"given":"Lotfi B","family":"Merabet","sequence":"additional","affiliation":[{"name":"Laboratory of Visual Neuroplasticity, Department of Ophthalmology , , 20 Staniford Street, Boston, MA 02114 ,","place":["United States"]},{"name":"Massachusetts Eye and Ear , , 20 Staniford Street, Boston, MA 02114 ,","place":["United States"]},{"name":"Department of Ophthalmology, Harvard Medical School , 243 Charles Street, Boston, MA 02114 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9407-4657","authenticated-orcid":false,"given":"Corinna 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