{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T17:06:23Z","timestamp":1754154383392,"version":"3.41.2"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81125009","81701126"],"award-info":[{"award-number":["81125009","81701126"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Foundation for Distinguished Scholars of Zhejiang University","award":["188020-193810101\/089"],"award-info":[{"award-number":["188020-193810101\/089"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Wilson\u2019s disease is an inherited disorder of copper metabolism. Despite significant advancements in neuroimaging studies, prior research into the pathological mechanism of Wilson\u2019s disease has ignored the crucial impact of mutation on the disease. This study examined brain imaging in relation to mutation in patients with Wilson\u2019s disease. A total of 57 Wilson\u2019s disease patients and 25 healthy controls were recruited in the current research. Patients were classified as having either the p.R778L or the p.P992L mutation (N\u2009=\u200943) or other mutations (N\u2009=\u200914). Utilizing the amplitude of low-frequency fluctuations, fractional amplitude of low-frequency fluctuations, and voxel-based morphology, the brain function and structure of Wilson\u2019s disease were explored. Compared to healthy controls, Wilson\u2019s disease patients with the p.R778L or p.P992L mutation showed greater atrophy in the bilateral putamen, caudate, globus pallidus, thalamus, amygdala, insula, and hippocampus. And these patients showed altered spontaneous neural activity in many more brain regions than healthy controls in three frequency bands. Significant correlation was found between altered brain volume and Unified Wilson\u2019s Disease Rating Scale neurological subscale scores. These findings reveal the functional and structural characteristics of Wilson\u2019s disease and emphasize the importance of exploring the neuroimaging correlation of genetic mutations in Wilson\u2019s disease.<\/jats:p>","DOI":"10.1093\/cercor\/bhaf186","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T07:59:08Z","timestamp":1750406348000},"source":"Crossref","is-referenced-by-count":0,"title":["Neuroimaging correlates of genetics in patients with Wilson\u2019s disease"],"prefix":"10.1093","volume":"35","author":[{"given":"Yang","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Medical Genetics and Center for Rare Diseases, the Second Affiliated Hospital, Zhejiang University School of Medicine and Zhejiang Key Laboratory of Rare Disease for Precision Medicine and Clinical Translation, Nanhu Brain-computer Interface Institute , 88 Jiefang Road, Hangzhou, Zhejiang Province, 310009 ,","place":["China"]},{"name":"Department of Psychiatry, the Second Affiliated Hospital, Zhejiang University School of Medicine , 88 Jiefang Road, Hangzhou, Zhejiang Province, 310009 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rou-Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics and Center for Rare Diseases, the Second Affiliated Hospital, Zhejiang University School of Medicine and Zhejiang Key Laboratory of Rare Disease for Precision Medicine and Clinical Translation, Nanhu Brain-computer Interface Institute , 88 Jiefang Road, Hangzhou, Zhejiang Province, 310009 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics and Center for Rare Diseases, the Second Affiliated Hospital, Zhejiang University School of Medicine and Zhejiang Key Laboratory of Rare Disease for Precision Medicine and Clinical Translation, Nanhu Brain-computer Interface Institute , 88 Jiefang Road, Hangzhou, Zhejiang Province, 310009 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4698-8723","authenticated-orcid":false,"given":"Xi-Ze","family":"Jia","sequence":"additional","affiliation":[{"name":"School of Psychology, Zhejiang Normal University , 688 Yingbin Avenue, Jinhua, Zhejiang Province, 321004 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2106-572X","authenticated-orcid":false,"given":"Zhi-Ying","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics and Center for Rare Diseases, the Second Affiliated Hospital, Zhejiang University School of Medicine and Zhejiang Key Laboratory of Rare Disease for Precision Medicine and Clinical Translation, Nanhu Brain-computer Interface Institute , 88 Jiefang Road, Hangzhou, Zhejiang Province, 310009 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"2025072403175609700_ref1","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/S0140-6736(07)60196-2","article-title":"Wilson\u2019s disease","volume":"369","author":"Ala","year":"2007","journal-title":"Lancet."},{"key":"2025072403175609700_ref2","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.tics.2017.11.005","article-title":"Frontal cortex and the hierarchical control of behavior","volume":"22","author":"Badre","year":"2018","journal-title":"Trends Cogn Sci"},{"key":"2025072403175609700_ref3","doi-asserted-by":"publisher","first-page":"185","DOI":"10.2165\/00023210-200519030-00001","article-title":"Neurologically presenting Wilson\u2019s disease: epidemiology, pathophysiology and treatment","volume":"19","author":"Brewer","year":"2005","journal-title":"CNS Drugs"},{"key":"2025072403175609700_ref4","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.1126\/science.1099745","article-title":"Neuronal oscillations in cortical networks","volume":"304","author":"Buzsaki","year":"2004","journal-title":"Science."},{"key":"2025072403175609700_ref5","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/s41572-018-0018-3","article-title":"Wilson disease","volume":"4","author":"Cz\u0142onkowska","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"2025072403175609700_ref6","doi-asserted-by":"publisher","first-page":"3018","DOI":"10.1093\/brain\/awae050","article-title":"Anatomo-functional basis of emotional and motor resonance elicited by facial expressions","volume":"147","author":"Del Vecchio","year":"2024","journal-title":"Brain."},{"key":"2025072403175609700_ref7","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1002\/jmri.26984","article-title":"Multiparametric quantitative brain MRI in neurological and hepatic forms of Wilson\u2019s disease","volume":"51","author":"Dezortova","year":"2020","journal-title":"J Magn Reson Imaging"},{"key":"2025072403175609700_ref8","doi-asserted-by":"publisher","first-page":"638","DOI":"10.7150\/thno.14596","article-title":"Spectrum and classification of ATP7b variants in a large cohort of Chinese patients with Wilson\u2019s disease guides genetic diagnosis","volume":"6","author":"Dong","year":"2016","journal-title":"Theranostics."},{"key":"2025072403175609700_ref9","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1111\/nan.12341","article-title":"Brain iron accumulation in Wilson disease: a post mortem 7 tesla MRI\u2014histopathological study","volume":"43","author":"Dusek","year":"2017","journal-title":"Neuropathol Appl Neurobiol"},{"key":"2025072403175609700_ref10","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1148\/radiol.2021202846","article-title":"Associations of brain atrophy and cerebral iron accumulation at MRI with clinical severity in Wilson disease","volume":"299","author":"Dusek","year":"2021","journal-title":"Radiology."},{"key":"2025072403175609700_ref11","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.jhep.2011.11.007","article-title":"EASL Clinical Practice Guidelines: Wilson\u2019s disease","volume":"56","author":"European Association for Study of Liver","year":"2012","journal-title":"J Hepatol"},{"key":"2025072403175609700_ref12","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s00439-006-0202-5","article-title":"Regional distribution of mutations of the ATP7B gene in patients with Wilson disease: impact on genetic testing","volume":"120","author":"Ferenci","year":"2006","journal-title":"Hum Genet"},{"key":"2025072403175609700_ref13","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1002\/mrm.1910350312","article-title":"Movement-related effects in fMRI time-series","volume":"35","author":"Friston","year":"1996","journal-title":"Magn Reson Med"},{"key":"2025072403175609700_ref14","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1038\/s41593-018-0221-2","article-title":"Selective vulnerability in neurodegenerative diseases","volume":"21","author":"Fu","year":"2018","journal-title":"Nat Neurosci"},{"key":"2025072403175609700_ref15","doi-asserted-by":"publisher","first-page":"788765","DOI":"10.3389\/fnagi.2021.788765","article-title":"Intrinsic brain activity alterations in patients with mild cognitive impairment-to-normal reversion: a resting-state functional magnetic resonance imaging study from voxel to whole-brain level","volume":"13","author":"Hu","year":"2021","journal-title":"Front Aging Neurosci"},{"key":"2025072403175609700_ref16","doi-asserted-by":"publisher","first-page":"9223","DOI":"10.1093\/cercor\/bhad182","article-title":"Metal deposits associated with brain atrophy in the deep gray matter nucleus in Wilson\u2019s disease","volume":"33","author":"Huang","year":"2023","journal-title":"Cereb Cortex"},{"key":"2025072403175609700_ref17","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.bpg.2010.07.014","article-title":"Wilson disease","volume":"24","author":"Huster","year":"2010","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"2025072403175609700_ref18","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/j.scib.2019.05.008","article-title":"RESTplus: an improved toolkit for resting-state functional magnetic resonance imaging data processing","volume":"64","author":"Jia","year":"2019","journal-title":"Sci Bull"},{"key":"2025072403175609700_ref19","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.jad.2019.09.063","article-title":"Common and distinct neural activities in frontoparietal network in first-episode bipolar disorder and major depressive disorder: preliminary findings from a follow-up resting state fMRI study","volume":"260","author":"Jiang","year":"2020","journal-title":"J Affect Disord"},{"key":"2025072403175609700_ref20","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1016\/j.neuroimage.2004.10.033","article-title":"Changes in brain activation associated with use of a memory strategy: a functional MRI study","volume":"24","author":"Kondo","year":"2005","journal-title":"NeuroImage."},{"key":"2025072403175609700_ref21","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/S0301-0082(03)00088-1","article-title":"Nature versus nurture revisited: an old idea with a new twist","volume":"70","author":"Krubitzer","year":"2003","journal-title":"Prog Neurobiol"},{"key":"2025072403175609700_ref22","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1002\/mds.28141","article-title":"Quantitative measurement of metal accumulation in brain of patients with Wilson\u2019s disease","volume":"35","author":"Li","year":"2020","journal-title":"Mov Disord"},{"key":"2025072403175609700_ref23","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1471-2350-12-6","article-title":"Clinical and molecular characterization of Wilson\u2019s disease in China: identification of 14 novel mutations","volume":"12","author":"Li","year":"2011","journal-title":"BMC Med Genet"},{"key":"2025072403175609700_ref24","doi-asserted-by":"publisher","first-page":"727","DOI":"10.3390\/brainsci14070727","article-title":"Brain magnetic resonance imaging in Wilson\u2019s disease\u2014significance and practical aspects\u2014a narrative review","volume":"14","author":"Litwin","year":"2024","journal-title":"Brain Sci"},{"key":"2025072403175609700_ref25","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s11011-013-9378-2","article-title":"The effect of gender on brain MRI pathology in Wilson\u2019s disease","volume":"28","author":"Litwin","year":"2013","journal-title":"Metab Brain Dis"},{"key":"2025072403175609700_ref26","doi-asserted-by":"publisher","first-page":"590","DOI":"10.3748\/wjg.v10.i4.590","article-title":"Correlation of ATP7B genotype with phenotype in Chinese patients with Wilson disease","volume":"10","author":"Liu","year":"2004","journal-title":"World J Gastroenterol"},{"key":"2025072403175609700_ref27","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.3174\/ajnr.A0611","article-title":"Decrease in the volume of white matter lesions with improvement of hepatic encephalopathy","volume":"28","author":"M\u00ednguez","year":"2007","journal-title":"AJNR Am J Neuroradiol"},{"key":"2025072403175609700_ref28","doi-asserted-by":"publisher","first-page":"3201","DOI":"10.1007\/s10072-024-07371-5","article-title":"Correlation between neuroimaging, neurological phenotype, and functional outcomes in Wilson\u2019s disease","volume":"45","author":"Moura","year":"2024","journal-title":"Neurol Sci"},{"key":"2025072403175609700_ref29","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1034\/j.1600-0447.2000.90085.x","article-title":"Psychopathology in treated Wilson\u2019s disease determined by means of CPRS expert and self-ratings","volume":"101","author":"Portala","year":"2000","journal-title":"Acta Psychiatr Scand"},{"key":"2025072403175609700_ref30","doi-asserted-by":"publisher","first-page":"4405","DOI":"10.1007\/s10072-022-06001-2","article-title":"Brain magnetic resonance imaging and severity of neurological disease in Wilson\u2019s disease\u2014the neuroradiological correlations","volume":"43","author":"R\u0119dzia-Ogrodnik","year":"2022","journal-title":"Neurol Sci"},{"key":"2025072403175609700_ref31","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/0022-510X(69)90115-4","article-title":"Thalamic correlated of language and speech","volume":"8","author":"Riklan","year":"1969","journal-title":"J Neurol Sci"},{"key":"2025072403175609700_ref32","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1152\/physrev.00002.2003","article-title":"The amygdaloid complex: anatomy and physiology","volume":"83","author":"Sah","year":"2003","journal-title":"Physiol Rev"},{"key":"2025072403175609700_ref33","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1136\/jnnp-2021-326123","article-title":"Wilson\u2019s disease: update on pathogenesis, biomarkers and treatments","volume":"92","author":"Shribman","year":"2021","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2025072403175609700_ref34","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/brain\/awab274","article-title":"Neuroimaging correlates of brain injury in Wilson\u2019s disease: a multimodal, whole-brain MRI study","volume":"145","author":"Shribman","year":"2022","journal-title":"Brain."},{"key":"2025072403175609700_ref35","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1002\/mds.29123","article-title":"Neuroimaging correlates of cognitive deficits in Wilson\u2019s disease","volume":"37","author":"Shribman","year":"2022","journal-title":"Mov Disord"},{"key":"2025072403175609700_ref36","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.neuroimage.2013.05.039","article-title":"Resting-state fMRI in the Human Connectome Project","volume":"80","author":"Smith","year":"2013","journal-title":"NeuroImage."},{"key":"2025072403175609700_ref37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2021\/9948751","article-title":"Altered small-world functional network topology in patients with optic neuritis: a resting-state fMRI study","volume":"2021","author":"Song","year":"2021","journal-title":"Dis Markers"},{"key":"2025072403175609700_ref38","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1007\/s11682-020-00373-9","article-title":"Whole brain volume and cortical thickness abnormalities in Wilson\u2019s disease: a clinical correlation study","volume":"15","author":"Song","year":"2021","journal-title":"Brain Imaging Behav"},{"key":"2025072403175609700_ref39","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.parkreldis.2016.06.017","article-title":"Exploring cortical atrophy and its clinical and biochemical correlates in Wilson\u2019s disease using voxel based morphometry","volume":"30","author":"Stezin","year":"2016","journal-title":"Parkinsonism Relat Disord"},{"key":"2025072403175609700_ref40","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.neuroimage.2013.10.051","article-title":"Impact of image acquisition on voxel-based-morphometry investigations of age-related structural brain changes","volume":"87","author":"Streitb\u00fcrger","year":"2014","journal-title":"NeuroImage."},{"key":"2025072403175609700_ref41","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.neuroimage.2018.11.011","article-title":"Assessment of mesoscopic properties of deep gray matter iron through a model-based simultaneous analysis of magnetic susceptibility and R2*\u2014a pilot study in patients with multiple sclerosis and normal controls","volume":"186","author":"Taege","year":"2019","journal-title":"NeuroImage."},{"key":"2025072403175609700_ref42","doi-asserted-by":"publisher","first-page":"1762","DOI":"10.1002\/hbm.21145","article-title":"Gray and white matter asymmetries in healthy individuals aged 21-29 years: a voxel-based morphometry and diffusion tensor imaging study","volume":"32","author":"Takao","year":"2011","journal-title":"Hum Brain Mapp"},{"key":"2025072403175609700_ref43","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/S0959-4388(96)80028-6","article-title":"New concepts of the supplementary motor area","volume":"6","author":"Tanji","year":"1996","journal-title":"Curr Opin Neurobiol"},{"key":"2025072403175609700_ref44","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1006\/nimg.2001.0978","article-title":"Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain","volume":"15","author":"Tzourio-Mazoyer","year":"2002","journal-title":"NeuroImage."},{"key":"2025072403175609700_ref45","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/S0926-6410(01)00010-6","article-title":"Thalamic volume predicts performance on tests of cognitive speed and decreases in healthy aging. A magnetic resonance imaging-based volumetric analysis","volume":"11","author":"Van Der Werf","year":"2001","journal-title":"Brain Res Cogn Brain Res"},{"key":"2025072403175609700_ref46","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1002\/hep.31681","article-title":"Neurodegeneration in hepatic and neurologic Wilson\u2019s disease","volume":"74","author":"Viveiros","year":"2021","journal-title":"Hepatology."},{"key":"2025072403175609700_ref47","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s12264-017-0107-4","article-title":"Wilson\u2019s disease in China","volume":"33","author":"Xie","year":"2017","journal-title":"Neurosci Bull"},{"key":"2025072403175609700_ref48","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3389\/fnsys.2010.00013","article-title":"DPARSF: a MATLAB toolbox for \u201cpipeline\u201d data analysis of resting-state fMRI","volume":"4","author":"Yan","year":"2010","journal-title":"Front Syst Neurosci"},{"key":"2025072403175609700_ref49","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.braindev.2006.07.002","article-title":"Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI","volume":"29","author":"Zang","year":"2007","journal-title":"Brain Dev"},{"key":"2025072403175609700_ref50","first-page":"703","article-title":"Evaluating the functional activity of the subcortical nuclei in Wilson's disease using resting state functional magnetic resonance imaging [in Chinese]","volume":"49","author":"Zhou","year":"2016","journal-title":"Chin J Neurol"},{"key":"2025072403175609700_ref51","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.mcn.2015.05.005","article-title":"Defective roles of ATP7B missense mutations in cellular copper tolerance and copper excretion","volume":"67","author":"Zhu","year":"2015","journal-title":"Mol Cell Neurosci"},{"key":"2025072403175609700_ref52","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1111\/cns.12091","article-title":"EGFP tags affect cellular localization of ATP7B mutants","volume":"19","author":"Zhu","year":"2013","journal-title":"CNS Neurosci Ther"},{"key":"2025072403175609700_ref53","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1172\/JCI45401","article-title":"Liver mitochondrial membrane crosslinking and destruction in a rat model of Wilson disease","volume":"121","author":"Zischka","year":"2011","journal-title":"J Clin Invest"},{"key":"2025072403175609700_ref54","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1002\/mds.27641","article-title":"Regional morphometric abnormalities and clinical relevance in Wilson\u2019s disease","volume":"34","author":"Zou","year":"2019","journal-title":"Mov Disord"},{"key":"2025072403175609700_ref55","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.jneumeth.2008.04.012","article-title":"An improved approach to detection of amplitude of low-frequency fluctuation (ALFF) for resting-state fMRI: fractional ALFF","volume":"172","author":"Zou","year":"2008","journal-title":"J Neurosci Methods"},{"key":"2025072403175609700_ref56","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1016\/j.neuroimage.2009.09.037","article-title":"The oscillating brain: complex and reliable","volume":"49","author":"Zuo","year":"2010","journal-title":"NeuroImage."}],"container-title":["Cerebral Cortex"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cercor\/article-pdf\/35\/7\/bhaf186\/63836668\/bhaf186.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cercor\/article-pdf\/35\/7\/bhaf186\/63836668\/bhaf186.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T07:18:05Z","timestamp":1753341485000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cercor\/article\/doi\/10.1093\/cercor\/bhaf186\/8211469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":56,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cercor\/bhaf186","relation":{},"ISSN":["1047-3211","1460-2199"],"issn-type":[{"type":"print","value":"1047-3211"},{"type":"electronic","value":"1460-2199"}],"subject":[],"published-other":{"date-parts":[[2025,7]]},"published":{"date-parts":[[2025,7,1]]},"article-number":"bhaf186"}}