{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T23:22:50Z","timestamp":1780442570241,"version":"3.54.1"},"reference-count":200,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1940096"],"award-info":[{"award-number":["1940096"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2116707"],"award-info":[{"award-number":["2116707"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2207733"],"award-info":[{"award-number":["2207733"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Social isolation during development, especially in adolescence, has detrimental but incompletely understood effects on the brain. This study investigated the neural correlates of preference for solitude and social withdrawal in a sample of 2809 youth [median (IQR) age\u2009=\u200912.0 (1.1) years, 1440 (51.26%) females] from the Adolescent Brain Cognitive Development study. Older youth whose parents had mental health issues more frequently preferred solitude and\/or were socially withdrawn (\u03b2\u00a0=\u20090.04 to 0.14, CI\u2009=\u2009[0.002, 0.19], P\u00a0&amp;lt;\u20090.05), both of which were associated with internalizing and externalizing behaviors, depression, and anxiety (\u03b2\u00a0=\u20090.25 to 0.45, CI\u2009=\u2009[0.20, 0.49], P\u00a0&amp;lt;\u20090.05). Youth who preferred solitude and\/or were socially withdrawn had lower cortical thickness in regions involved in social function (cuneus, insula, anterior cingulate, and superior temporal gyri) and\/or mental health (\u03b2\u00a0=\u2009\u22120.09 to \u22120.02, CI\u2009=\u2009[\u22120.14, \u22120.003], P\u00a0&amp;lt;\u20090.05), and higher amygdala, entorhinal cortex, parahippocampal gyrus, and basal ganglia volume (\u03b2\u00a0=\u20092.62 to 668.10, CI\u2009=\u2009[0.13, 668.10], P\u00a0&amp;lt;\u20090.05). Youth who often preferred solitude had more topologically segregated dorsal attention, temporoparietal, and social networks (\u03b2\u00a0=\u20090.07 to 0.10, CI\u2009=\u2009[0.02, 0.14], P\u00a0\u2264\u20090.03). Socially withdrawn youth had a less topologically robust and efficient (\u03b2\u00a0=\u2009\u22120.05 to \u22120.80, CI\u2009=\u2009[\u22121.34,\u22120.01], P\u00a0&amp;lt;\u20090.03) and more fragile cerebellum (\u03b2\u00a0=\u20090.04, CI\u2009=\u2009[0.01, 0.07], P\u00a0&amp;lt;\u20090.05). These findings suggest that social isolation in adolescence may be a risk factor for widespread alterations in brain regions supporting social function and mental health.<\/jats:p>","DOI":"10.1093\/cercor\/bhaf260","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T11:34:57Z","timestamp":1755948897000},"source":"Crossref","is-referenced-by-count":3,"title":["Neural correlates of social withdrawal and preference for solitude in adolescence"],"prefix":"10.1093","volume":"35","author":[{"given":"Matthew","family":"Risner","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Adolescent and Young Adult Medicine, Boston Children\u2019s Hospital , 300 Longwood Avenue, Boston, MA 02115 ,","place":["United 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