{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:44:44Z","timestamp":1761666284751,"version":"build-2065373602"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Innovation Team Program in Philosophy and Social Science of Yunnan Province","award":["202405\u00a0AC350075"],"award-info":[{"award-number":["202405\u00a0AC350075"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024\u00a0M750240"],"award-info":[{"award-number":["2024\u00a0M750240"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["2022-I2M-1-002"],"award-info":[{"award-number":["2022-I2M-1-002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Previous studies have shown that individuals with internet gaming disorder (IGD) and tobacco use disorder (TUD) represent nonsubstance and substance-related addictions, respectively. Identifying neuroimaging differences is essential for detecting and intervening in these disorders. 44 IGD participants, 73 TUD participants, and 33 healthy controls (HCs) were scanned with resting-state fMRI (rs-fMRI). We used independent component analysis (ICA) to identify regions of interest and compared the functional connectivity between groups using a false discovery rate correction. Rs-fMRI revealed increased functional connectivity in the precuneus cortex, left postcentral gyrus, and right superior frontal gyrus in the dorsal attention network (DAN) in the IGD group in contrast to HC group. In the TUD group, increased functional connectivity was observed in the superior frontal gyrus, supplementary motor cortex, right precentral gyrus, cingulate gyrus, anterior division, postcentral gyrus, thalamus r, and thalamus I. In contrast, decreased functional connectivity was observed in the right lateral occipital cortex (the inferior and superior division), right occipital fusiform gyrus, and the right occipital pole. Our results indicate distinct alterations in the DAN associated with IGD and TUD, suggesting divergent mechanisms in behavioral versus substance-related addictions.<\/jats:p>","DOI":"10.1093\/cercor\/bhaf296","type":"journal-article","created":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T11:44:12Z","timestamp":1759664652000},"source":"Crossref","is-referenced-by-count":0,"title":["The alteration of dorsal attention network in internet gaming disorder and tobacco use disorder: an independent component analysis"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3898-8136","authenticated-orcid":false,"given":"Yan","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College , 5 Dongdan Santiao, Dongcheng District, Beijing 100005 ,","place":["China"]},{"name":"Neuroscience Center, Chinese Academy of Medical Sciences , 5 Dongdan Santiao, Dongcheng District, Beijing 100005 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanliang","family":"Wei","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Xinxiang Medical University , No. 88 Jiankang Road, Weihui City, Xinxiang, Henan Province 453199 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YueSong","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College , 5 Dongdan Santiao, Dongcheng District, Beijing 100005 ,","place":["China"]},{"name":"Neuroscience Center, Chinese Academy of Medical Sciences , 5 Dongdan Santiao, Dongcheng District, Beijing 100005 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianbo","family":"Xiu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College , 5 Dongdan Santiao, Dongcheng District, Beijing 100005 ,","place":["China"]},{"name":"State Key Laboratory of Complex, Severe, and Rare Diseases , School of Basic Medicine Peking Union Medical College, 5 Dongdan Santiao, Dongcheng District, Beijing 100005 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangheng","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Psychology, Yunnan Normal University , No. 768 Juxian Street, Chenggong District, Kunming, Yunnan Province 650500 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"2025102811362264200_ref1","first-page":"1","article-title":"Behavioral addictions: the substance of \u201cnon-substance related addictive disorders\u201d","volume":"23","author":"Ali","year":"2021","journal-title":"Int J Emerg Ment Health"},{"key":"2025102811362264200_ref2","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1038\/s42003-022-04281-0","article-title":"The subcortical and neurochemical organization of the ventral and dorsal attention networks","volume":"5","author":"Alves","year":"2022","journal-title":"Commun Biol"},{"key":"2025102811362264200_ref3","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.neuroimage.2007.04.042","article-title":"A component based noise correction method (CompCor) for BOLD and perfusion based fMRI","volume":"37","author":"Behzadi","year":"2007","journal-title":"NeuroImage"},{"key":"2025102811362264200_ref4","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1146\/annurev-neuro-061010-113734","article-title":"Reward, addiction, withdrawal to nicotine","volume":"34","author":"Biasi","year":"2011","journal-title":"Annu Rev Neurosci"},{"key":"2025102811362264200_ref5","doi-asserted-by":"publisher","first-page":"3315","DOI":"10.1093\/brain\/awl244","article-title":"Functions of the left superior frontal gyrus in humans: a lesion study","volume":"129","author":"Boisgueheneuc","year":"2006","journal-title":"Brain"},{"key":"2025102811362264200_ref6","volume-title":"Non-verbal working memory: a functional near-infrared spectroscopy (fNIRS) and functional magnetic resonance imaging (fMRI) comparison","author":"Brekke","year":"2023"},{"key":"2025102811362264200_ref7","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1109\/RBME.2012.2211076","article-title":"Multisubject independent component analysis of fMRI: a decade of intrinsic networks, default mode, and neurodiagnostic discovery","volume":"5","author":"Calhoun","year":"2012","journal-title":"IEEE Rev Biomed Eng"},{"key":"2025102811362264200_ref8","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1002\/hbm.1048","article-title":"A method for making group inferences from functional MRI data using independent component analysis","volume":"14","author":"Calhoun","year":"2001","journal-title":"Hum Brain Mapp"},{"key":"2025102811362264200_ref9","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1093\/brain\/awl004","article-title":"The precuneus: a review of its functional anatomy and behavioural correlates","volume":"129","author":"Cavanna","year":"2006","journal-title":"Brain"},{"key":"2025102811362264200_ref10","doi-asserted-by":"publisher","first-page":"2607","DOI":"10.1002\/hbm.26233","article-title":"Internet gaming disorder and tobacco use disorder share neural connectivity patterns between the subcortical and the motor network","volume":"44","author":"Chen","year":"2023","journal-title":"Hum Brain Mapp"},{"key":"2025102811362264200_ref11","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/978-1-4939-0968-1_2","volume-title":"Neuroplasticity and virtual reality. Virtual reality for physical and motor rehabilitation","author":"Cheung","year":"2014"},{"key":"2025102811362264200_ref12","doi-asserted-by":"crossref","first-page":"8081670","DOI":"10.1155\/2018\/8081670","article-title":"A comparison of gender differences in smoking behaviors, intention to quit, and nicotine dependence among Thai university students","volume":"2018","author":"Chinwong","year":"2018","journal-title":"J Addict"},{"key":"2025102811362264200_ref13","doi-asserted-by":"publisher","first-page":"17753","DOI":"10.1523\/JNEUROSCI.3272-12.2012","article-title":"Altered functional brain connectivity in a non-clinical sample of young adults with attention-deficit\/hyperactivity disorder","volume":"32","author":"Cocchi","year":"2012","journal-title":"J Neurosci"},{"key":"2025102811362264200_ref14","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1002\/hbm.23117","article-title":"Intrinsic functional connectivity of periaqueductal gray subregions in humans","volume":"37","author":"Coulombe","year":"2016","journal-title":"Hum Brain Mapp"},{"key":"2025102811362264200_ref15","volume-title":"Neuroanatomy, postcentral gyrus. StatPearls [internet]","author":"Diguiseppi","year":"2023"},{"key":"2025102811362264200_ref16","doi-asserted-by":"publisher","first-page":"e59902","DOI":"10.1371\/journal.pone.0059902","article-title":"Altered default network resting-state functional connectivity in adolescents with internet gaming addiction","volume":"8","author":"Ding","year":"2013","journal-title":"PLoS One"},{"key":"2025102811362264200_ref17","doi-asserted-by":"publisher","first-page":"109829","DOI":"10.1016\/j.pnpbp.2019.109829","article-title":"Addiction severity modulates the precuneus involvement in internet gaming disorder: functionality, morphology and effective connectivity","volume":"98","author":"Dong","year":"2020","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"2025102811362264200_ref18","doi-asserted-by":"publisher","first-page":"727055","DOI":"10.3389\/fneur.2021.727055","article-title":"Cortical and subcortical anatomy of the parietal lobe from the neurosurgical perspective","volume":"12","author":"Dziedzic","year":"2021","journal-title":"Front Neurol"},{"key":"2025102811362264200_ref19","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3233\/JAD-180847","article-title":"Resting state abnormalities of the default mode network in mild cognitive impairment: a systematic review and meta-analysis","volume":"70","author":"Eyler","year":"2019","journal-title":"J Alzheimers Dis"},{"key":"2025102811362264200_ref20","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1097\/ADM.0b013e318233d637","article-title":"Internet addiction as an important predictor in early detection of adolescent drug use experience\u2014implications for research and practice","volume":"6","author":"Fisoun","year":"2012","journal-title":"J Addict Med"},{"key":"2025102811362264200_ref21","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1017\/S0140525X00045167","article-title":"Supplementary motor area structure and function: review and hypotheses","volume":"8","author":"Goldberg","year":"1985","journal-title":"Behav Brain Sci"},{"key":"2025102811362264200_ref22","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1155\/NP.2003.107","article-title":"The basal ganglia and motor control","volume":"10","author":"Groenewegen","year":"2003","journal-title":"Neural Plast"},{"key":"2025102811362264200_ref23","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1001\/archgenpsychiatry.2009.2","article-title":"Association of nicotine addiction and nicotine's actions with separate cingulate cortex functional circuits","volume":"66","author":"Hong","year":"2009","journal-title":"Arch Gen Psychiatry"},{"key":"2025102811362264200_ref24","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1038\/35094560","article-title":"Addiction and the brain: the neurobiology of compulsion and its persistence","volume":"2","author":"Hyman","year":"2001","journal-title":"Nat Rev Neurosci"},{"key":"2025102811362264200_ref25","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1037\/a0017797","article-title":"Brain fMRI reactivity to smoking-related images before and during extended smoking abstinence","volume":"17","author":"Janes","year":"2009","journal-title":"Exp Clin Psychopharmacol"},{"key":"2025102811362264200_ref26","doi-asserted-by":"publisher","first-page":"3795","DOI":"10.1002\/hbm.20807","article-title":"Dysregulation of working memory and default-mode networks in schizophrenia using independent component analysis, an fBIRN and MCIC study","volume":"30","author":"Kim","year":"2009","journal-title":"Hum Brain Mapp"},{"key":"2025102811362264200_ref27","doi-asserted-by":"publisher","first-page":"1494313","DOI":"10.3389\/fpubh.2024.1494313","article-title":"Neuromodulatory effect of transcranial direct current stimulation on cue reactivity and craving in young adults with internet gaming disorder: an event-related potential study","volume":"12","author":"Kim","year":"2025","journal-title":"Front Public Health"},{"key":"2025102811362264200_ref28","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/j.jpsychires.2012.11.008","article-title":"The brain activations for both cue-induced gaming urge and smoking craving among subjects comorbid with internet gaming addiction and nicotine dependence","volume":"47","author":"Ko","year":"2013","journal-title":"J Psychiatr Res"},{"key":"2025102811362264200_ref29","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/S0924-9338(97)83296-8","article-title":"The MINI international neuropsychiatric interview (MINI). A short diagnostic structured interview: reliability and validity according to the CIDI","volume":"12","author":"Lecrubier","year":"1997","journal-title":"Eur Psychiatry"},{"key":"2025102811362264200_ref30","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1556\/2006.2020.00060","article-title":"Aberrant posterior superior temporal sulcus functional connectivity and executive dysfunction in adolescents with internet gaming disorder","volume":"9","author":"Lee","year":"2020","journal-title":"J Behav Addict"},{"key":"2025102811362264200_ref31","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1002\/hbm.20359","article-title":"Estimating the number of independent components for functional magnetic resonance imaging data","volume":"28","author":"Li","year":"2007","journal-title":"Hum Brain Mapp"},{"key":"2025102811362264200_ref32","doi-asserted-by":"publisher","first-page":"2494","DOI":"10.1109\/JBHI.2019.2893880","article-title":"Functional brain network estimation with time series self-scrubbing","volume":"23","author":"Li","year":"2019","journal-title":"IEEE J Biomed Health Inform"},{"key":"2025102811362264200_ref33","doi-asserted-by":"publisher","first-page":"4849","DOI":"10.1109\/JBHI.2022.3190277","article-title":"Human-guided functional connectivity network estimation for chronic tinnitus identification: a modularity view","volume":"26","author":"Li","year":"2022","journal-title":"IEEE J Biomed Health Inform"},{"key":"2025102811362264200_ref34","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1038\/s41398-021-01566-6","article-title":"Neural substrates of propranolol-induced impairments in the reconsolidation of nicotine-associated memories in smokers","volume":"11","author":"Lin","year":"2021","journal-title":"Transl Psychiatry"},{"key":"2025102811362264200_ref35","doi-asserted-by":"publisher","first-page":"8724","DOI":"10.1038\/s41598-018-27057-1","article-title":"Effects of repeated transcranial direct current stimulation on smoking, craving and brain reactivity to smoking cues","volume":"8","author":"Mondino","year":"2018","journal-title":"Sci Rep"},{"key":"2025102811362264200_ref36","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1111\/j.1460-9568.2011.07814.x","article-title":"Enhanced visual perception with occipital transcranial magnetic stimulation","volume":"34","author":"Mulckhuyse","year":"2011","journal-title":"Eur J Neurosci"},{"key":"2025102811362264200_ref37","doi-asserted-by":"publisher","first-page":"e426","DOI":"10.1016\/j.wneu.2021.04.050","article-title":"Anatomy and white matter connections of the lingual gyrus and cuneus","volume":"151","author":"Palejwala","year":"2021","journal-title":"World Neurosurg"},{"key":"2025102811362264200_ref38","doi-asserted-by":"publisher","first-page":"S62","DOI":"10.1038\/522S62a","article-title":"Perspective: behavioural addictions matter","volume":"522","author":"Potenza","year":"2015","journal-title":"Nature"},{"key":"2025102811362264200_ref39","doi-asserted-by":"publisher","DOI":"10.5817\/CP2025-1-1","article-title":"Prevalence and impact of internet gaming disorder: a population-based study","volume":"19","author":"Razum","year":"2025","journal-title":"Cyberpsychology: Journal of Psychosocial Research on Cyberspace"},{"key":"2025102811362264200_ref40","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3109\/07853899809029940","article-title":"Role of the limbic system in dependence on drugs","volume":"30","author":"Rodriguez","year":"1998","journal-title":"Ann Med"},{"key":"2025102811362264200_ref41","doi-asserted-by":"publisher","first-page":"3001","DOI":"10.1007\/s00429-019-01945-2","article-title":"The cingulate cortex and limbic systems for emotion, action, and memory","volume":"224","author":"Rolls","year":"2019","journal-title":"Brain Struct Funct"},{"key":"2025102811362264200_ref42","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1093\/cercor\/bhr099","article-title":"Decoding subject-driven cognitive states with whole-brain connectivity patterns","volume":"22","author":"Shirer","year":"2012","journal-title":"Cereb Cortex"},{"key":"2025102811362264200_ref43","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3389\/fpsyg.2012.00161","article-title":"Early and sustained supramarginal gyrus contributions to phonological processing","volume":"3","author":"Sliwinska","year":"2012","journal-title":"Front Psychol"},{"key":"2025102811362264200_ref44","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/j.1748-6653.2011.02008.x","article-title":"An independent component analysis of fMRI data of grapheme\u2013colour synaesthesia","volume":"5","author":"Specht","year":"2011","journal-title":"J Neuropsychol"},{"key":"2025102811362264200_ref45","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1176\/ajp.155.8.1009","article-title":"Nicotine-induced limbic cortical activation in the human brain: a functional MRI study","volume":"155","author":"Stein","year":"1998","journal-title":"Am J Psychiatry"},{"key":"2025102811362264200_ref46","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1159\/000050456","article-title":"Epidemiology of chronic obstructive pulmonary disease (COPD)","volume":"68","author":"Viegi","year":"2001","journal-title":"Respiration"},{"key":"2025102811362264200_ref47","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1017\/S1092852917000360","article-title":"Group independent component analysis reveals alternation of right executive control network in internet gaming disorder","volume":"23","author":"Wang","year":"2018","journal-title":"CNS Spectr"},{"key":"2025102811362264200_ref48","doi-asserted-by":"publisher","first-page":"23779608231158158","DOI":"10.1177\/23779608231158158","article-title":"Prevalence and risk factors of internet gaming disorder under the COVID-19 pandemic among university students in Macao","volume":"9","author":"Wang","year":"2023","journal-title":"SAGE Open Nurs"},{"key":"2025102811362264200_ref49","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1089\/brain.2012.0073","article-title":"Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks","volume":"2","author":"Whitfield-Gabrieli","year":"2012","journal-title":"Brain Connect"},{"key":"2025102811362264200_ref50","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1002\/(SICI)1097-0193(1996)4:1&lt;58::AID-HBM4&gt;3.0.CO;2-O","article-title":"A unified statistical approach for determining significant signals in images of cerebral activation","volume":"4","author":"Worsley","year":"1996","journal-title":"Hum Brain Mapp"},{"key":"2025102811362264200_ref51","doi-asserted-by":"publisher","first-page":"872","DOI":"10.3390\/brainsci11070872","article-title":"Revisiting the morphology and classification of the paracingulate gyrus with commentaries on ambiguous cases","volume":"11","author":"Wysiadecki","year":"2021","journal-title":"Brain Sci"},{"key":"2025102811362264200_ref52","doi-asserted-by":"publisher","first-page":"1404050","DOI":"10.3389\/fpsyt.2024.1404050","article-title":"Resting-state brain networks alterations in adolescents with internet gaming disorder associate with cognitive control impairments","volume":"15","author":"Zhao","year":"2024","journal-title":"Front Psych"},{"key":"2025102811362264200_ref53","doi-asserted-by":"publisher","first-page":"e13119","DOI":"10.1111\/adb.13119","article-title":"Similarities and differences between internet gaming disorder and tobacco use disorder: a large-scale network study","volume":"27","author":"Zheng","year":"2022","journal-title":"Addict Biol"},{"key":"2025102811362264200_ref54","doi-asserted-by":"publisher","first-page":"111119","DOI":"10.1016\/j.pnpbp.2024.111119","article-title":"Similarities and differences in dynamic properties of brain networks between internet gaming disorder and tobacco use disorder","volume":"135","author":"Zheng","year":"2024","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"2025102811362264200_ref55","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/S1076-6332(03)00671-8","article-title":"Statistical validation of image segmentation quality based on a spatial overlap index1: scientific reports","volume":"11","author":"Zou","year":"2004","journal-title":"Acad Radiol"}],"container-title":["Cerebral Cortex"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cercor\/article-pdf\/35\/10\/bhaf296\/65004912\/bhaf296.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cercor\/article-pdf\/35\/10\/bhaf296\/65004912\/bhaf296.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:36:55Z","timestamp":1761665815000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cercor\/article\/doi\/10.1093\/cercor\/bhaf296\/8305240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":55,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10,2]]}},"URL":"https:\/\/doi.org\/10.1093\/cercor\/bhaf296","relation":{},"ISSN":["1047-3211","1460-2199"],"issn-type":[{"value":"1047-3211","type":"print"},{"value":"1460-2199","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,10]]},"article-number":"bhaf296"}}