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This is believed to rely on internal models\u2014neural representations that predict motor command outcomes\u2014enabling computation of sensory prediction errors. These models support learning generalization, ie application of newly learned movements to new situations, effectors, or state space regions not directly encountered during practice. Prior studies show that focal left posterior parietal cortex lesions impair visuomotor adaptation in both arms, implicating posterior parietal cortex in sensorimotor recalibration. Here, we investigated the posterior parietal cortex\u2019s role in visuomotor adaptation and interlimb generalization using anodal high-definition transcranial direct current stimulation (HD-tDCS). Sixty adults performed dominant (right) arm reaches while adapting to a 2D 30\u00b0 cursor rotation, concurrent with HD-tDCS targeting the left posterior parietal cortex, right posterior parietal cortex, or under sham conditions. Stimulation was then discontinued, and participants repeated the task with their non-dominant (left) arm to assess interlimb generalization. HD-tDCS over left or right posterior parietal cortex had no effect on initial adaptation (P\u2009=\u20090.77). However, left posterior parietal cortex stimulation was associated with enhanced interlimb generalization (P\u2009=\u20090.003) whereas right posterior parietal cortex stimulation was not (P\u2009=\u20090.77). This suggests that anodal transcranial direct current stimulation to contralateral posterior parietal cortex may contribute to interlimb generalization of visuomotor adaptation, rather than adaptation itself.<\/jats:p>","DOI":"10.1093\/cercor\/bhag013","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:06:53Z","timestamp":1773770813000},"source":"Crossref","is-referenced-by-count":0,"title":["Anodal high-definition transcranial direct current stimulation reveals a specific role for posterior parietal cortex in interlimb generalization"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7488-8992","authenticated-orcid":false,"given":"Brooke","family":"Dexheimer","sequence":"first","affiliation":[{"name":"Department of Occupational Therapy, Virginia Commonwealth University , 900 E. Leigh Street, Richmond, VA 23298 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick M","family":"Kitchen","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, Penn State University , 27 Rec Hall, University Park, PA 16802 ,","place":["United States"]},{"name":"Department of Neurology, Penn State College of Medicine , 700 HMC Crescent Road, Hershey, PA 17033 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terrence E","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Penn State College of Medicine , 90 Hope Drive, Hershey, PA 17033 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jisung","family":"Yuk","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, The MetroHealth System, Case Western Reserve University School of Medicine , 4229 Pearl Road, Cleveland, OH 44195 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathew","family":"Yarossi","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Movement and Rehabilitation Sciences, Northeastern University , 360 Huntington Avenue, Boston, MA 02115 ,","place":["United States"]},{"name":"Department of Electrical and Computer Engineering, Northeastern University , 360 Huntington Avenue, Boston, MA 02115 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene","family":"Tunik","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Movement and Rehabilitation Sciences, Northeastern University , 360 Huntington Avenue, Boston, MA 02115 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert L","family":"Sainburg","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, 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