{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T18:06:43Z","timestamp":1793815603367,"version":"4.6.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The insula serves as an integrative hub across sensory, affective, and cognitive domains, yet its heterogeneous connectivity architecture has been largely overlooked in obsessive\u2013compulsive disorder (OCD). Using both discrete parcellation and continuous gradient approaches, we comprehensively characterized insula functional connectivity (FC) alterations in 92 medication-free, noncomorbid OCD patients and 90 healthy controls. Data-driven clustering divided the insula into anterior and posterior subregions, followed by a diagnosis-by-subregion factorial analysis of variance (ANOVA) to assess group differences. OCD patients showed unbalanced subregional FC alterations with the supplementary motor area, precentral gyrus, and dorsolateral prefrontal cortex, exhibiting increased anterior and decreased posterior insula FC, with a significant effect in the anterior subregion. Within OCD patients, anterior insula\u2013dorsolateral prefrontal FC was negatively correlated with obsession severity. Gradient analysis further revealed reduced explanation ratio, gradient range, and variation in the left insula, but these effects did not survive correction for multiple comparisons. Together, these results indicate that insula FC alterations in OCD are more localized to specific subregions rather than reflecting a large-scale gradient shift, with anterior insula dysconnectivity emerging as a key feature linked to obsessive symptoms.<\/jats:p>","DOI":"10.1093\/cercor\/bhag063","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:59:23Z","timestamp":1777377563000},"source":"Crossref","is-referenced-by-count":1,"title":["Characterizing insula functional connectivity alterations in obsessive\u2013compulsive disorder: from parcellation and gradient models"],"prefix":"10.1093","volume":"36","author":[{"given":"Lingxiao","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Radiology and Huaxi MR Research Center (HMRRC), Institute of Radiology and Medical Imaging, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University , No. 37 Guo Xue Xiang, Chengdu , Sichuan, 610041,","place":["China"]},{"name":"Psychoradiology Key Laboratory of Sichuan Province, West China Hospital of Sichuan University , No. 37 Guo Xue Xiang, Chengdu , Sichuan, 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology and Huaxi MR Research Center (HMRRC), Institute of Radiology and Medical Imaging, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University , No. 37 Guo Xue Xiang, Chengdu , Sichuan, 610041,","place":["China"]},{"name":"Psychoradiology Key Laboratory of Sichuan Province, West China Hospital of Sichuan University , No. 37 Guo Xue Xiang, Chengdu , Sichuan, 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Mental Health Center, West China Hospital, Sichuan University , No. 37 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610041,","place":["China"]},{"name":"Psychoradiology Key Laboratory of Sichuan Province, West China Hospital of Sichuan University , No. 37 Guo Xue Xiang, Chengdu , Sichuan, 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5912-4871","authenticated-orcid":false,"given":"Qiyong","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Radiology and Huaxi MR Research Center (HMRRC), Institute of Radiology and Medical Imaging, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University , No. 37 Guo Xue Xiang, Chengdu , Sichuan, 610041,","place":["China"]},{"name":"Department of Radiology, West China Xiamen Hospital of Sichuan University , No. 699 Jinyuan West Road, Xiamen, Fujian , 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